The Many Roles for Fluorine in Medicinal Chemistry von Hagmann, William K

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production von Miller, Corin, Pachanski, Michele J, Kirkland, Melissa E, Kosinski, Daniel T, Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B, Li, Xiaoyan, Myers, Robert W, Knagge, Kevin, Carrington, Paul E, Hagmann, William K, Trujillo, Maria E

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[¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor von Burns, H. Donald, Van Laere, Koen, Sanabria-Bohórquez, Sandra, Hamill, Terence G, Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K, Jewell, James P, Lin, Linus S, Liu, Ping, Goulet, Mark T, Gottesdiener, Keith, Wagner, John A, de Hoon, Jan, Mortelmans, Luc, Fong, Tung M, Hargreaves, Richard J

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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes von Wilson, Jonathan E., Kurukulasuriya, Ravi, Sinz, Christopher, Lombardo, Matthew, Bender, Kate, Parker, Dann, Sherer, Edward C., Costa, Melissa, Dingley, Karen, Li, Xiaofang, Mitelman, Stanley, Tong, Sharon, Bugianesi, Randal, Ehrhardt, Anka, Priest, Birgit, Ratliff, Kevin, Ujjainwalla, Feroze, Nargund, Ravi, Hagmann, William K., Edmondson, Scott

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QSAR Prediction of Passive Permeability in the LLC-PK1 Cell Line: Trends in Molecular Properties and Cross-Prediction of Caco-2 Permeabilities von Sherer, Edward C., Verras, Andreas, Madeira, Maria, Hagmann, William K., Sheridan, Robert P., Roberts, Drew, Bleasby, Kelly, Cornell, Wendy D.

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VLA-4 antagonists: Potent inhibitors of lymphocyte migration von Yang, Ginger X., Hagmann, William K.

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates von Mandal, Mihirbaran, Xiao, Li, Pan, Weidong, Scapin, Giovanna, Li, Guoqing, Tang, Haiqun, Yang, Shu-Wei, Pan, Jianping, Root, Yuriko, de Jesus, Reynalda Keh, Yang, Christine, Prosise, Winnie, Dayananth, Priya, Mirza, Asra, Therien, Alex G., Young, Katherine, Flattery, Amy, Garlisi, Charles, Zhang, Rumin, Chu, Donald, Sheth, Payal, Chu, Inhou, Wu, Jin, Markgraf, Carrie, Kim, Hai-Young, Painter, Ronald, Mayhood, Todd W., DiNunzio, Edward, Wyss, Daniel F., Buevich, Alexei V., Fischmann, Thierry, Pasternak, Alexander, Dong, Shuzhi, Hicks, Jacqueline D., Villafania, Artjohn, Liang, Lianzhu, Murgolo, Nicholas, Black, Todd, Hagmann, William K., Tata, Jim, Parmee, Emma R., Weber, Ann E., Su, Jing, Tang, Haifeng

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs von Pio, Barbara, Chobanian, Harry R., Guo, Yan, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Ashley, Eric, Orr, Robert, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Samuel, Koppara, Chen, Qing, Shang, Jackie, Lamca, James, Ehrhart, Juliann, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.

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The Discovery of Taranabant, a Selective Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity von Hagmann, William K.

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Synthesis and evaluation of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists von Du, Wu, Jewell, James P., Lin, Linus S., Colandrea, Vincent J., Xiao, Jing C., Lao, Julie, Shen, Chun-Pyn, Bateman, Thomas J., Reddy, Vijay B.G., Ha, Sookhee N., Shah, Shrenik K., Fong, Tung M., Hale, Jeffrey J., Hagmann, William K.

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Design and Synthesis of Novel, Selective GPR40 AgoPAMs von Plummer, Christopher W., Clements, Matthew J., Chen, Helen, Rajagopalan, Murali, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Nolting, Andrew F., Orr, Robert, Christensen, Melodie, Campeau, Louis-Charles, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists von He, Shuwen, Dobbelaar, Peter H., Guo, Liangqin, Ye, Zhixiong, Liu, Jian, Jian, Tianying, Truong, Quang, Shah, Shrenik K., Du, Wu, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James D., Sherer, Edward, Pasternak, Alexander, Feng, Zhe, Reibarkh, Mikhail, Lin, Melissa, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.

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Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists von Lai, Zhong, He, Shuwen, Sherer, Edward C., Wu, Zhicai, Yu, Yang, Ball, Richard, Hong, Qingmei, Yang, David X., Guo, Liangqing, Li, Derun, Tuang, Quang, Chicchi, Gary G., Trusca, Dorina, Tsao, Kwei-Lan, Zhou, Yun-Ping, Howard, Andrew D., Nargund, Ravi P., Hagmann, William K.

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The NMR structure of the inhibited catalytic domain of human stromelysin-1 von Gooley, Paul R, O'Connell, John F, Marcy, Alice I, Cuca, Gregory C, Salowe, Scott P, Bush, Bruce L, Hermes, Jeffrey D, Esser, Craig K, Hagmann, William K, Springer, James P, Johnson, Bruce A

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes von Guo, Liangqin, Parker, Dann L, Zang, Yi, Sweis, Ramzi F, Liu, Weiguo, Sherer, Edward C, Buist, Nicole, Terebetski, Jenna, Kelly, Terri, Bugianesi, Randal, Priest, Birgit T, Dingley, Karen H, Li, Xiaofang, Mitelman, Stan, Salituro, Gino, Trujillo, Maria E, Pachanski, Michele, Kirkland, Melissa, Powles, Mary Ann, Eiermann, George J, Feng, Yue, Shang, Jin, Howard, Andrew D, Ujjainwalla, Feroze, Sinz, Christopher J, Debenham, John S, Edmondson, Scott D, Nargund, Ravi P, Hagmann, William K, Li, Derun

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Comparative Assessment of the Ligand and Metal Ion Binding Properties of Integrins α9β1 and α4β1 von Pepinsky, R. Blake, Mumford, Richard A, Chen, Ling Ling, Leone, Diane, Amo, Suzanne E, Riper, Gail Van, Whitty, Adrian, Dolinski, Brian, Lobb, Roy R, Dean, Dennis C, Chang, Linda L, Raab, Conrad E, Si, Qian, Hagmann, William K, Lingham, Russell B

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Conformational Analysis and Receptor Docking of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (Tarana... von Lin, Linus S, Ha, Sookhee, Ball, Richard G, Tsou, Nancy N, Castonguay, Laurie A, Doss, George A, Fong, Tung M, Shen, Chun-Pyn, Xiao, Jing Chen, Goulet, Mark T, Hagmann, William K

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes von Shah, Shrenik K, He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Eiermann, George J, Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B, Howard, Andrew D, Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P, Hagmann, William K

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Substituted Imidazoles as Glucagon Receptor Antagonists von Chang, Linda L., Sidler, Kelly L., Cascieri, Margaret A., de Laszlo, Stephen, Koch, Greg, Li, Bing, MacCoss, Malcolm, Mantlo, Nathan, O'Keefe, Stephen, Pang, Margaret, Rolando, Anna, Hagmann, William K.

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Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells von Xiao, Jing Chen, Jewell, James P, Lin, Linus S, Hagmann, William K, Fong, Tung M, Shen, Chun-Pyn

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