A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509 von Joseph, James D, Lu, Nhin, Qian, Jing, Sensintaffar, John, Shao, Gang, Brigham, Dan, Moon, Michael, Maneval, Edna Chow, Chen, Isan, Darimont, Beatrice, Hager, Jeffrey H

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Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-Resistant Prostate Cancer von RATHKOPF, Dana E, MORRIS, Michael J, FLEISHER, Martin, LARSON, Steven M, SAWYERS, Charles L, SCHER, Howard I, FOX, Josef J, DANILA, Daniel C, SLOVIN, Susan F, HAGER, Jeffrey H, RIX, Peter J, CHOW ANEVAL, Edna, CHEN, Isan, GÖNEN, Mithat

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ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment von CLEGG, Nicola J, WONGVIPAT, John, APARICIO, Anna, DOROW, Steven, ARORA, Vivek, GANG SHAO, JING QIAN, HONG ZHAO, GUANGBIN YANG, CHUNYAN CAO, SENSINTAFFAR, John, WASIELEWSKA, Teresa, JOSEPH, James D, HERBERT, Mark R, BONNEFOUS, Celine, DARIMONT, Beatrice, SCHER, Howard I, SMITH-JONES, Peter, KLANG, Mark, SMITH, Nicholas D, DE STANCHINA, Elisa, NIAN WU, OUERFELLI, Ouathek, TRAN, Chris, RIX, Peter J, HEYMAN, Richard A, JUNG, Michael E, SAWYERS, Charles L, HAGER, Jeffrey H, OUK, Samedy, DILHAS, Anna, YU CHEN, GRILLOT, Kate, BISCHOFF, Eric D, LING CAI

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Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability von Kategaya, Lorn, Perumal, Senthil K., Hager, Jeffrey H., Belmont, Lisa D.

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis von Joyce, Johanna A, Baruch, Amos, Chehade, Kareem, Meyer-Morse, Nicole, Giraudo, Enrico, Tsai, Fong-Ying, Greenbaum, Doron C, Hager, Jeffrey H, Bogyo, Matthew, Hanahan, Douglas

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Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility von Guan, Jane, Zhou, Wei, Hafner, Marc, Blake, Robert A., Chalouni, Cecile, Chen, Irene P., De Bruyn, Tom, Giltnane, Jennifer M., Hartman, Steven J., Heidersbach, Amy, Houtman, Rene, Ingalla, Ellen, Kategaya, Lorn, Kleinheinz, Tracy, Li, Jun, Martin, Scott E., Modrusan, Zora, Nannini, Michelle, Oeh, Jason, Ubhayakar, Savita, Wang, Xiaojing, Wertz, Ingrid E., Young, Amy, Yu, Mamie, Sampath, Deepak, Hager, Jeffrey H., Friedman, Lori S., Daemen, Anneleen, Metcalfe, Ciara

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Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout von Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, Hager, Jeffrey H., Hanahan, Douglas, Edlund, Helena, Magnuson, Mark A., Garrett-Beal, Lisa, Burns, A. Lee, Ried, Thomas, Chandrasekharappa, Settara C., Marx, Stephen J., Spiegel, Allen M., Collins, Francis S.

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Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xeno... von Lai, Andiliy, Kahraman, Mehmet, Govek, Steven, Nagasawa, Johnny, Bonnefous, Celine, Julien, Jackie, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, Kyoung-jin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Moon, Michael J, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Grillot, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling von Feng, Rentian, Ma, Huihui, Hassig, Christian A, Payne, Joseph E, Smith, Nicholas D, Mapara, Markus Y, Hager, Jeffrey H, Lentzsch, Suzanne

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Author Correction: A multilineage screen identifies actionable synthetic lethal interactions in human cancers von Fong, Samson H, Kuenzi, Brent M, Mattson, Nicole M, Lee, John, Sanchez, Kyle, Bojorquez-Gomez, Ana, Ford, Kyle, Munson, Brenton P, Licon, Katherine, Bergendahl, Sarah, Shen, John Paul, Kreisberg, Jason F, Mali, Prashant, Hager, Jeffrey H, White, Michael A, Ideker, Trey

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A multilineage screen identifies actionable synthetic lethal interactions in human cancers von Fong, Samson H., Kuenzi, Brent M., Mattson, Nicole M., Lee, John, Sanchez, Kyle, Bojorquez-Gomez, Ana, Ford, Kyle, Munson, Brenton P., Licon, Katherine, Bergendahl, Sarah, Shen, John Paul, Kreisberg, Jason F., Mali, Prashant, Hager, Jeffrey H., White, Michael A., Ideker, Trey

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Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer von Hager, Jeffrey H, Ulanet, Danielle B, Hennighausen, Lothar, Hanahan, Douglas

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XIAP is not required for human tumor cell survival in the absence of an exogenous death signal von Sensintaffar, John, Scott, Fiona L, Peach, Robert, Hager, Jeffrey H

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Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cance... von Nagasawa, Johnny, Govek, Steven, Kahraman, Mehmet, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Maheu, Kate, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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Maximizing ER‑α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927 von Kahraman, Mehmet, Govek, Steven P, Nagasawa, Johnny Y, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Liu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D, Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J, Hager, Jeffrey H, Smith, Nicholas D

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VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis von Inoue, Masahiro, Hager, Jeffrey H, Ferrara, Napoleone, Gerber, Hans-Peter, Hanahan, Douglas

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Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis von Casanovas, Oriol, Hager, Jeffrey H, Chun, Matthew Gee Hong, Hanahan, Douglas

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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo von Hassig, Christian A, Symons, Kent T, Guo, Xin, Nguyen, Phan-Manh, Annable, Tami, Wash, Paul L, Payne, Joseph E, Jenkins, David A, Bonnefous, Céline, Trotter, Carol, Wang, Yan, Anzola, John V, Milkova, Elena L, Hoffman, Timothy Z, Dozier, Sara J, Wiley, Brandon M, Saven, Alan, Malecha, James W, Davis, Robert L, Muhammad, Jerry, Shiau, Andrew K, Noble, Stewart A, Rao, Tadimeti S, Smith, Nicholas D, Hager, Jeffrey H

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Identification of KD5170 : A novel mercaptoketone-based histone deacetylase inhibitor von PAYNE, Joseph E, BONNEFOUS, Céline, SHIAU, Andrew K, MALECHA, James W, NOBLE, Stewart A, HAGER, Jeffrey H, SMITH, Nicholas D, HASSIG, Christian A, SYMONS, Kent T, XIN GUO, NGUYEN, Phan-Manh, ANNABLE, Tami, WASH, Paul L, HOFFMAN, Timothy Z, RAO, Tadimeti S

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Hormone-Targeted Therapy and Resistance von Metcalfe, Ciara, Friedman, Lori S, Hager, Jeffrey H

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