A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis von Ligocki, A.J, Lovato, L, Xiang, D, Guidry, P, Scheuermann, R.H, Willis, S.N, Almendinger, S, Racke, M.K, Frohman, E.M, Hafler, D.A, O'Connor, K.C, Monson, N.L

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SP0104 The Molecular Basis of Autoimmune Disease von Hafler, D.A.

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HLA B44: protective effects in MS susceptibility and MRI outcome measures von Healy, B C, Liguori, M, Tran, D, Chitnis, T, Glanz, B, Wolfish, C, Gauthier, S, Buckle, G, Houtchens, M, Stazzone, L, Khoury, S, Hartzmann, R, Fernandez-Vina, M, Hafler, D A, Weiner, H L, Guttmann, C R G, De Jager, P L

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A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility von Bush, W S, McCauley, J L, DeJager, P L, Dudek, S M, Hafler, D A, Gibson, R A, Matthews, P M, Kappos, L, Naegelin, Y, Polman, C H, Hauser, S L, Oksenberg, J, Haines, J L, Ritchie, M D

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Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis von Vosslamber, S, van der Voort, L F, van den Elskamp, I J, Heijmans, R, Aubin, C, Uitdehaag, B M J, Crusius, J B A, van der PouwKraan, T C T M, Comabella, M, Montalban, X, Hafler, D A, De Jager, P L, Killestein, J, Polman, C H, Verweij, C L

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A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis von Ban, M, McCauley, J L, Zuvich, R, Baker, A, Bergamaschi, L, Cox, M, Kemppinen, A, D'Alfonso, S, Guerini, F R, Lechner-Scott, J, Dudbridge, F, Wason, J, Robertson, N P, De Jager, P L, Hafler, D A, Barcellos, L F, Ivinson, A J, Sexton, D, Oksenberg, J R, Hauser, S L, Pericak-Vance, M A, Haines, J, Compston, A, Sawcer, S

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Case 37-1995: A 6-year-old boy with a rash, meningismus, and diplegia von Hafler, D.A, Hedley-Whyte, E.T

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In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis von Schmied, M, Duda, P.W, Krieger, J.I, Trollmo, C, Hafler, D.A

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Treatment of progressive multiple sclerosis with pulse cyclophosphamide/ methylprednisolone : Response to therapy is linked to the duration of progressive disease von HOHOL, M. J, OLEK, M. J, ORAV, E. J, STAZZONE, L, HAFLER, D. A, KHOURY, S. J, DAWSON, D. M, WEINER, H. L

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Early signaling defects in human T cells anergized by T cell presentation of autoantigen von LASALLE, J. M, TOLENTINO, P. J, FREEMAN, G. J, NADLER, L. M, HAFLER, D.A

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Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I von RICHARDSON, J. H, HÖLLSBERG, P, WINDHAGEN, A, CHILD, L. A, HAFLER, D. A, LEVER, A. M. L

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The expanding genetic overlap between multiple sclerosis and type I diabetes von Booth, D.R, Heard, R.N, Stewart, G.J, Goris, An, Dobosi, Rita, Dubois, Bénédicte, Lorentzen, A.R, Celius, E.G, Harbo, H.F, Spurkland, A, Olsson, T, Kockum, I, Link, J, Hillert, J, Ban, M, Baker, A, Sawcer, S, Compston, A, Mihalova, T, Strange, R, Hawkins, C, Ingram, G, Robertson, N.P, De Jager, P.L, Hafler, D.A, Barcellos, L.F, Ivinson, A.J, Pericak-Vance, M, Oksenberg, J.R, Hauser, S.L, McCauley, J.L, Sexton, D, Haines, J

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Refining genetic associations in multiple sclerosis von Booth, D, Heard, R, Stewart, G, Goris, An, Dobosi, Rita, Dubois, Bénédicte, Oturai, A, Soendergaard, H.B, Sellebjerg, F, Saarela, J, Leppä, V, Palotie, A, Peltonen, L, Fontaine, B, Cournu-Rebeix, I, Clerget-Darpoux, F, Babron, M.C, Weber, F, Holsboer, F, Müller-Myhsok, B, Rieckmann, P, Kroner, A, Graham, C, Vandenbroeck, K, Hawkins, S, D'Alfonso, S, Bergamaschi, L, Naldi, P, Guerini, F.R, Salvetti, M, Galimberti, D, Hintzen, R, van Duijn, C, Lorentzen, A.R, Celius, E.G, Harbo, H.F, Spurkland, A, Cucca, F, Marrosu, M.G, Comabella, M, Montalban, X, Villoslada, P, Olsson, T, Kockum, I, Hillert, J, Ban, M, Walton, A, Sawcer, S, Compston, A, Hawkins, C, Mihalova, T, Robertson, N, Ingram, G, De Jager, P.L, Hafler, D.A, Rioux, J, Daly, M, Barcellos, L, Ivinson, A, Pericak-Vance, M, Oksenberg, J, Hauser, S.L, McCauley, J, Sexton, D, Haines, J

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The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases von De Jager, P.L, Franchimont, D, Waliszewska, A, Bitton, A, Cohen, A, Langelier, D, Belaiche, J, Vermeire, Severine, Farwell, L, Goris, An, Libioulle, C, Jani, N, Dassopoulos, T, Bromfield, G.P, Dubois, Bénédicte, Cho, J.H, Brant, S.R, Duerr, R.H, Yang, Hu, Rotter, J.I, Silverberg, M.S, Steinhart, A.H, Daly, M.J, Podolsky, D.K, Louis, E, Hafler, D.A, Rioux, J.D

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In vitro analysis of T-cell responses to Copaxone von Duda, P.W., Krieger, J.I., Hafler, D.A.

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CTLA4 engagement can have both positive and negative effects on human T cell activation von Anderson, D.E., Bieganowska, K., Bar-Or, A., Hafler, D.A.

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CTLA4 blockade enhances B7-2 dependent Th-2 cytokine production from human MBP-reactive T-cells von Bar-Or, A., Anderson, D.E., Bieganowska, K., Hafler, D.A.

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Effect of CD28/CTLA4 signaling on function of MBP reactive T cells von Bieganowska, K., Anderson, D.E., Bar-Or, A., Hafler, D.A.

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Increased expression of CDIIb (mac-1) on CD8+ T cells in patients with HAM/TSP von Buckle, G.J., Batra, V., Hafler, D.A., Hollsberg, P.

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Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells von Scholz, C., Hafler, D.A., Höllsberg, P.

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