Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling von Haling, Jacob R., Sudhamsu, Jawahar, Yen, Ivana, Sideris, Steve, Sandoval, Wendy, Phung, Wilson, Bravo, Brandon J., Giannetti, Anthony M., Peck, Ariana, Masselot, Alexandre, Morales, Tony, Smith, Darin, Brandhuber, Barbara J., Hymowitz, Sarah G., Malek, Shiva

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Regulation and functions of the IL-10 family of cytokines in inflammation and disease von Ouyang, Wenjun, Rutz, Sascha, Crellin, Natasha K, Valdez, Patricia A, Hymowitz, Sarah G

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Targeting the MAPK Pathway in RAS Mutant Cancers von Hymowitz, Sarah G, Malek, Shiva

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A20: from ubiquitin editing to tumour suppression von Wertz, Ingrid E, Hymowitz, Sarah G

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 von Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

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K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody von Matsumoto, Marissa L., Wickliffe, Katherine E., Dong, Ken C., Yu, Christine, Bosanac, Ivan, Bustos, Daisy, Phu, Lilian, Kirkpatrick, Donald S., Hymowitz, Sarah G., Rape, Michael, Kelley, Robert F., Dixit, Vishva M.

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Therapeutic antibody targeting of individual Notch receptors von Zha, Jiping, Dow, Graham J, Chen, Yongmei, Watts, Ryan J, Callahan, Christopher A, Finkle, David, Wu, Yan, Hagenbeek, Thijs J, Venook, Rayna, de Leon, Gladys P, Siebel, Christian W, Choy, Lisa, Cain-Hom, Carol, Choy, Robert, Schahin-Reed, Dorreyah, Ridgway, John, Yan, Minhong, Stawicki, Scott, Hymowitz, Sarah G, Wu, Xiumin, Shelton, Amy, Kadyk, Lisa, Howard, Peter, Zhang, Jeff

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Interactions between Hedgehog proteins and their binding partners come into view von Beachy, Philip A, Hymowitz, Sarah G, Lazarus, Robert A, Leahy, Daniel J, Siebold, Christian

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Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation von Liau, Nicholas P D, Venkatanarayan, Avinashnarayan, Quinn, John G, Phung, Wilson, Malek, Shiva, Hymowitz, Sarah G, Sudhamsu, Jawahar

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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL von Ashkenazi, Avi, Lancaster, Kate, Punnoose, Elizabeth A, Lee, Dori, Pitti, Robert M, Lawrence, David A, Totpal, Klara, Hymowitz, Sarah G, Cavet, Guy, Huw, Ling, Wagner, Klaus W, von Goetz, Melissa, Yee, Sharon Fong, Katta, Viswanatham, Amler, Lukas, Januario, Thomas

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Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization von Liau, Nicholas P. D., Wendorff, Timothy J., Quinn, John G., Steffek, Micah, Phung, Wilson, Liu, Peter, Tang, Jia, Irudayanathan, Flaviyan J., Izadi, Saeed, Shaw, Andrey S., Malek, Shiva, Hymowitz, Sarah G., Sudhamsu, Jawahar

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Structural basis for SHOC2 modulation of RAS signalling von Liau, Nicholas P. D., Johnson, Matthew C., Izadi, Saeed, Gerosa, Luca, Hammel, Michal, Bruning, John M., Wendorff, Timothy J., Phung, Wilson, Hymowitz, Sarah G., Sudhamsu, Jawahar

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Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies von Tilegenova, Cholpon, Izadi, Saeed, Yin, Jianping, Huang, Christine S, Wu, Jiansheng, Ellerman, Diego, Hymowitz, Sarah G, Walters, Benjamin, Salisbury, Cleo, Carter, Paul J

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc von Fauber, Benjamin P., de Leon Boenig, Gladys, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, René, Olivier, Wong, Harvey

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Unveiling the Structural and Dynamic Nature of the Ubiquitin Code von Di Lello, Paola, Hymowitz, Sarah G.

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Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation von Dey, Anwesha, Seshasayee, Dhaya, Noubade, Rajkumar, French, Dorothy M., Liu, Jinfeng, Chaurushiya, Mira S., Kirkpatrick, Donald S., Pham, Victoria C., Lill, Jennie R., Bakalarski, Corey E., Wu, Jiansheng, Phu, Lilian, Katavolos, Paula, LaFave, Lindsay M., Abdel-Wahab, Omar, Modrusan, Zora, Seshagiri, Somasekar, Dong, Ken, Lin, Zhonghua, Balazs, Mercedesz, Suriben, Rowena, Newton, Kim, Hymowitz, Sarah, Garcia-Manero, Guillermo, Martin, Flavius, Levine, Ross L., Dixit, Vishva M.

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Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody von Matsumoto, Marissa L., Dong, Ken C., Yu, Christine, Phu, Lilian, Gao, Xinxin, Hannoush, Rami N., Hymowitz, Sarah G., Kirkpatrick, Donald S., Dixit, Vishva M., Kelley, Robert F.

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The Crystal Structure of the Costimulatory OX40-OX40L Complex von Compaan, Deanne M., Hymowitz, Sarah G.

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Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies von Newton, Kim, Matsumoto, Marissa L., Wertz, Ingrid E., Kirkpatrick, Donald S., Lill, Jennie R., Tan, Jenille, Dugger, Debra, Gordon, Nathaniel, Sidhu, Sachdev S., Fellouse, Frederic A., Komuves, Laszlo, French, Dorothy M., Ferrando, Ronald E., Lam, Cynthia, Compaan, Deanne, Yu, Christine, Bosanac, Ivan, Hymowitz, Sarah G., Kelley, Robert F., Dixit, Vishva M.

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Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity von Huang, Christine S., Oberbeck, Nina, Hsiao, Yi-Chun, Liu, Peter, Johnson, Adam R., Dixit, Vishva M., Hymowitz, Sarah G.

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