Regulation and functions of the IL-10 family of cytokines in inflammation and disease von Ouyang, Wenjun, Rutz, Sascha, Crellin, Natasha K, Valdez, Patricia A, Hymowitz, Sarah G

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Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling von Haling, Jacob R., Sudhamsu, Jawahar, Yen, Ivana, Sideris, Steve, Sandoval, Wendy, Phung, Wilson, Bravo, Brandon J., Giannetti, Anthony M., Peck, Ariana, Masselot, Alexandre, Morales, Tony, Smith, Darin, Brandhuber, Barbara J., Hymowitz, Sarah G., Malek, Shiva

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 von Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

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K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody von Matsumoto, Marissa L., Wickliffe, Katherine E., Dong, Ken C., Yu, Christine, Bosanac, Ivan, Bustos, Daisy, Phu, Lilian, Kirkpatrick, Donald S., Hymowitz, Sarah G., Rape, Michael, Kelley, Robert F., Dixit, Vishva M.

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Therapeutic antibody targeting of individual Notch receptors von Wu, Yan, Cain-Hom, Carol, Choy, Lisa, Hagenbeek, Thijs J., de Leon, Gladys P., Chen, Yongmei, Finkle, David, Venook, Rayna, Wu, Xiumin, Ridgway, John, Schahin-Reed, Dorreyah, Dow, Graham J., Shelton, Amy, Stawicki, Scott, Watts, Ryan J., Zhang, Jeff, Choy, Robert, Howard, Peter, Kadyk, Lisa, Yan, Minhong, Zha, Jiping, Callahan, Christopher A., Hymowitz, Sarah G., Siebel, Christian W.

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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL von Wagner, Klaus W, Punnoose, Elizabeth A, Januario, Thomas, Lawrence, David A, Pitti, Robert M, Lancaster, Kate, Lee, Dori, von Goetz, Melissa, Yee, Sharon Fong, Totpal, Klara, Huw, Ling, Katta, Viswanatham, Cavet, Guy, Hymowitz, Sarah G, Amler, Lukas, Ashkenazi, Avi

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Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies von Tilegenova, Cholpon, Izadi, Saeed, Yin, Jianping, Huang, Christine S, Wu, Jiansheng, Ellerman, Diego, Hymowitz, Sarah G, Walters, Benjamin, Salisbury, Cleo, Carter, Paul J

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Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody von Matsumoto, Marissa L., Dong, Ken C., Yu, Christine, Phu, Lilian, Gao, Xinxin, Hannoush, Rami N., Hymowitz, Sarah G., Kirkpatrick, Donald S., Dixit, Vishva M., Kelley, Robert F.

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The Crystal Structure of the Costimulatory OX40-OX40L Complex von Compaan, Deanne M., Hymowitz, Sarah G.

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Unveiling the Structural and Dynamic Nature of the Ubiquitin Code von Di Lello, Paola, Hymowitz, Sarah G.

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Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity von Huang, Christine S., Oberbeck, Nina, Hsiao, Yi-Chun, Liu, Peter, Johnson, Adam R., Dixit, Vishva M., Hymowitz, Sarah G.

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc von Fauber, Benjamin P., de Leon Boenig, Gladys, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, René, Olivier, Wong, Harvey

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Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to... von Kelley, Robert F., Totpal, Klara, Lindstrom, Stephanie H., Mathieu, Mary, Billeci, Karen, DeForge, Laura, Pai, Roger, Hymowitz, Sarah G., Ashkenazi, Avi

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Targeting the MAPK Pathway in RAS Mutant Cancers von Hymowitz, Sarah G, Malek, Shiva

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Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834 von Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, Currie, Kevin S.

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In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation von Seshasayee, Dhaya, Lee, Wyne P, Zhou, Meijuan, Shu, Jean, Suto, Eric, Zhang, Juan, Diehl, Laurie, Austin, Cary D, Meng, Y Gloria, Tan, Martha, Bullens, Sherron L, Seeber, Stefan, Fuentes, Maria E, Labrijn, Aran F, Graus, Yvo M F, Miller, Lisa A, Schelegle, Edward S, Hyde, Dallas M, Wu, Lawren C, Hymowitz, Sarah G, Martin, Flavius

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Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield von Dong, Ken C., Helgason, Elizabeth, Yu, Christine, Phu, Lilian, Arnott, David P., Bosanac, Ivan, Compaan, Deanne M., Huang, Oscar W., Fedorova, Anna V., Kirkpatrick, Donald S., Hymowitz, Sarah G., Dueber, Erin C.

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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site von de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.

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Dimerization of LTβR by LTα₁β₂ is necessary and sufficient for signal transduction von Sudhamsu, Jawahar, Yin, JianPing, Chiang, Eugene Y., Starovasnik, Melissa A., Grogan, Jane L., Hymowitz, Sarah G.

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A20: from ubiquitin editing to tumour suppression von Hymowitz, Sarah G., Wertz, Ingrid E.

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