Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis von Lee, Brian Y., Hogg, Elizabeth K. J., Below, Christopher R., Kononov, Alexander, Blanco-Gomez, Adrian, Heider, Felix, Xu, Jingshu, Hutton, Colin, Zhang, Xiaohong, Scheidt, Tamara, Beattie, Kenneth, Lamarca, Angela, McNamara, Mairéad, Valle, Juan W., Jørgensen, Claus

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib von James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure von Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments von Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.

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A mini-colon models colon cancer and its microenvironment von Hutton, Colin, Li, Vivian S W

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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity von Hutton, Colin, Heider, Felix, Blanco-Gomez, Adrian, Banyard, Antonia, Kononov, Alexander, Zhang, Xiaohong, Karim, Saadia, Paulus-Hock, Viola, Watt, Dale, Steele, Nina, Kemp, Samantha, Hogg, Elizabeth K.J., Kelly, Joanna, Jackstadt, Rene-Filip, Lopes, Filipa, Menotti, Matteo, Chisholm, Luke, Lamarca, Angela, Valle, Juan, Sansom, Owen J., Springer, Caroline, Malliri, Angeliki, Marais, Richard, Pasca di Magliano, Marina, Zelenay, Santiago, Morton, Jennifer P., Jørgensen, Claus

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Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy von Pelly, Victoria S., Moeini, Agrin, Roelofsen, Lisanne M., Bonavita, Eduardo, Bell, Charlotte R., Hutton, Colin, Blanco-Gomez, Adrian, Banyard, Antonia, Bromley, Christian P., Flanagan, Eimear, Chiang, Shih-Chieh, Jorgensen, Claus, Schumacher, Ton N., Thommen, Daniela S., Zelenay, Santiago

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids von Below, Christopher R., Kelly, Joanna, Brown, Alexander, Humphries, Jonathan D., Hutton, Colin, Xu, Jingshu, Lee, Brian Y., Cintas, Celia, Zhang, Xiaohong, Hernandez-Gordillo, Victor, Stockdale, Linda, Goldsworthy, Matthew A., Geraghty, Joe, Foster, Lucy, O’Reilly, Derek A., Schedding, Barbara, Askari, Janet, Burns, Jessica, Hodson, Nigel, Smith, Duncan L., Lally, Catherine, Ashton, Garry, Knight, David, Mironov, Aleksandr, Banyard, Antonia, Eble, Johannes A., Morton, Jennifer P., Humphries, Martin J., Griffith, Linda G., Jørgensen, Claus

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Abstract B63: Mass cytometry identifies two distinct fibroblast lineages in pancreatic tumors that differentially regulate antitumor immunity von Hutton, Colin, Heider, Felix, Veluscek, Giulia, Zhang, Xiaohong, Morton, Jennifer, Jorgensen, Claus

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USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development von Novellasdemunt, Laura, Kucharska, Anna, Baulies, Anna, Hutton, Colin, Vlachogiannis, Georgios, Repana, Dimitra, Rowan, Andrew, Suárez-Bonnet, A., Ciccarelli, Francesca, Valeri, Nicola, Li, Vivian S.W.

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A microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids von Below, Christopher R., Kelly, Joanna, Brown, Alexander, Humphries, Jonathan D., Hutton, Colin, Xu, Jingshu, Lee, Brian Y., Cintas, Celia, Zhang, Xiaohong, Hernandez-Gordillo, Victor, Stockdale, Linda, Goldsworthy, Matthew A., Geraghty, Joe, Foster, Lucy, O’Reilly, Derek A., Schedding, Barbara, Askari, Janet, Burns, Jessica, Hodson, Nigel, Smith, Duncan L., Lally, Catherine, Ashton, Garry, Knight, David, Mironov, Aleksandr, Banyard, Antonia, Eble, Johannes A., Morton, Jennifer P., Humphries, Martin J., Griffith, Linda G., Jørgensen, Claus

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Abstract 3236: Delivering selective and cell-active inhibitors of V804M mutant RET kinase through structure-guided drug discovery von Jordan, Allan M., Newton, Rebecca, Waszkowycz, Bohdan, Bayliss, Richard, Begum, Habiba, Burschowsky, Daniel, Echalier, Aude, Hitchin, Samantha, Hutton, Colin, Johns, Shaun, Jones, Stuart, Lin, Li-Ying, Richards, Mark, Seewooruthun, Chitra, Stowell, Alex, Waddell, Ian, Watson, Mandy, Ogilvie, Donald

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Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate, Mcgonagle, Alison, Jordan, Allan, Acton, Ben, Fairweather, Emma, Griffiths, Louise, Hamilton, Niall M, Hamilton, Nicola, Hitchin, James R, Hutton, Colin, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel, Small, Helen F, Stowell, Alexandra, Tucker, Julie, Waddell, Ian, Ogilvie, Donald J

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Abstract 3715: Benzimidazolone sulphonamides - potent, selective and drug-like inhibitors of poly(ADP Ribose) Glycohydrolase (PARG) von Jordan, Allan, Acton, Ben, Hamilton, Nicola, Hitchin, James, Hutton, Colin, James, Dominic, Jones, Cliff, Jones, Stuart, McGonagle, Alison, Small, Helen, Smith, Kate, Stowell, Alex, Tucker, Julie, Waddell, Ian, Waszkowycz, Bohdan, Ogilvie, Donald

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Mineralogy of beach sands between Halfmoon and Monterey Bays, California von Hutton, C. Osborne 1910

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Abstract C39: First-in-class inhibitors of the putatively undruggable DNA repair target Poly(ADP-ribose) glycohydrolase (PARG) von Waszkowycz, Bohdan, James, Dominic, Acton, Ben, Fairweather, Emma, Fritzl, Sam, Hamilton, Niall, Hamilton, Nicola, Holt, Sarah, Hitchen, James, Hutton, Colin, Jones, Stuart, Jordan, Allan, McGonagle, Alison, Mould, Daniel, Small, Helen, Smith, Kate, Stowell, Alexandra, Waddell, Ian D., Ogilvie, Donald

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Abstract B98: Development and evaluation of selective, reversible LSD1 inhibitors from fragment startpoints von Stowell, Alex, Hamilton, Niall, Hitchin, James, Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma, Hutton, Colin, Jordan, Allan, Mould, Daniel, Thomson, Graeme, Waddell, Ian, Ogilvie, Donald

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Stromal heterogeneity in pancreatic cancer von Hutton, Colin

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h von Hitchin, James R, Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J, Fairweather, Emma E, Hutton, Colin, Jordan, Allan M, McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J, Waddell, Ian, Ogilvie, Donald J

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