Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbo... von Fensome, Andrew, Adams, William R, Adams, Andrea L, Berrodin, Tom J, Cohen, Jeff, Huselton, Christine, Illenberger, Arthur, Kern, Jeffrey C, Hudak, Valerie A, Marella, Michael A, Melenski, Edward G, McComas, Casey C, Mugford, Cheryl A, Slayden, Ov D, Yudt, Matthew, Zhang, Zhiming, Zhang, Puwen, Zhu, Yuan, Winneker, Richard C, Wrobel, Jay E

Volltext

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? von Sukoff Rizzo, Stacey J, Leonard, Sarah K, Gilbert, Adam, Dollings, Paul, Smith, Deborah L, Zhang, Mei-Yi, Di, Li, Platt, Brian J, Neal, Sarah, Dwyer, Jason M, Bender, Corey N, Zhang, Jean, Lock, Tim, Kowal, Dianne, Kramer, Angela, Randall, Andrew, Huselton, Christine, Vishwanathan, Karthick, Tse, Susanna Y, Butera, John, Ring, Robert H, Rosenzweig-Lipson, Sharon, Hughes, Zoë A, Dunlop, John

Volltext

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis von Hu, Baihua, Collini, Michael, Unwalla, Rayomand, Miller, Christopher, Singhaus, Robert, Quinet, Elaine, Savio, Dawn, Halpern, Anita, Basso, Michael, Keith, James, Clerin, Valerie, Chen, Liang, Resmini, Christine, Liu, Qiang-Yuan, Feingold, Irene, Huselton, Christine, Azam, Farooq, Farnegardh, Mathias, Enroth, Cristofer, Bonn, Tomas, Goos-Nilsson, Annika, Wilhelmsson, Anna, Nambi, Ponnal, Wrobel, Jay

Volltext

Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Re... von Pelletier, Jeffrey C, Chengalvala, Murty V, Cottom, Joshua E, Feingold, Irene B, Green, Daniel M, Hauze, Diane B, Huselton, Christine A, Jetter, James W, Kopf, Gregory S, Lundquist, Joseph T, Magolda, Ronald L, Mann, Charles W, Mehlmann, John F, Rogers, John F, Shanno, Linda K, Adams, William R, Tio, Cesario O, Wrobel, Jay E

Volltext

Structure–activity relationships of the 1-amino-3-(1 H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors von Mahaney, Paige E., Kim, Callain Y., Coghlan, Richard D., Cohn, Stephen T., Heffernan, Gavin D., Huselton, Christine A., Terefenko, Eugene A., Vu, An T., Zhang, Puwen, Burroughs, Kevin D., Cosmi, Scott A., Bray, Jenifer A., Johnston, Grace H., Deecher, Darlene C., Trybulski, Eugene J.

Volltext

5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists von Liu, Kevin G, Robichaud, Albert J, Bernotas, Ronald C, Yan, Yinfa, Lo, Jennifer R, Zhang, Mei-Yi, Hughes, Zoe A, Huselton, Christine, Zhang, Guo Ming, Zhang, Jean Y, Kowal, Dianne M, Smith, Deborah L, Schechter, Lee E, Comery, Thomas A

Volltext

3-(3-Aryloxyaryl)imidazo[1,2- a]pyridine sulfones as liver X receptor agonists von Singhaus, Robert R., Bernotas, Ronald C., Steffan, Robert, Matelan, Edward, Quinet, Elaine, Nambi, Ponnal, Feingold, Irene, Huselton, Christine, Wilhelmsson, Anna, Goos-Nilsson, Annika, Wrobel, Jay

Volltext

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models von GALAS, Jennifer M, LUCAS, Judy, FANGBIAO LI, TITSCH, Craig, HUSELTON, Christine, CHAUDHARY, Inder, BOSCHELLI, Frank, ETIENNE, Carlo, GOLAS, Jonathan, DISCAFANI, Carolyn, SRIDHARAN, Latha, BOGHAERT, Erwin, ARNDT, Kim, FEI YE, BOSCHELLI, Diane H

Volltext

Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis von Wrobel, Jay, Steffan, Robert, Bowen, S. Marc, Magolda, Ronald, Matelan, Edward, Unwalla, Rayomand, Basso, Michael, Clerin, Valerie, Gardell, Stephen J, Nambi, Ponnal, Quinet, Elaine, Reminick, Jason I, Vlasuk, George P, Wang, Shuguang, Feingold, Irene, Huselton, Christine, Bonn, Tomas, Farnegardh, Mathias, Hansson, Tomas, Nilsson, Annika Goos, Wilhelmsson, Anna, Zamaratski, Edouard, Evans, Mark J

Volltext

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists von Travins, Jeremy M., Bernotas, Ronald C., Kaufman, David H., Quinet, Elaine, Nambi, Ponnal, Feingold, Irene, Huselton, Christine, Wilhelmsson, Anna, Goos-Nilsson, Annika, Wrobel, Jay

Volltext

Novel progesterone receptor modulators: 4-Aryl-phenylsulfonamides von McComas, Casey, Cohen, Jeffrey, Huselton, Christine, Marella, Michael, Melenski, Edward, Mugford, Cheryl, Slayden, Ov, Winneker, Richard, Wrobel, Jay, Yudt, Matthew R., Fensome, Andrew

Volltext

Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague–Dawley rats von Alfinito, Peter D., Huselton, Christine, Chen, Xiaohong, Deecher, Darlene C.

Volltext

WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics von Grauer, Steven M., Graf, Radka, Navarra, Rachel, Sung, Amy, Logue, Sheree F., Stack, Gary, Huselton, Christine, Liu, Zhi, Comery, Thomas A., Marquis, Karen L., Rosenzweig-Lipson, Sharon

Volltext

Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatmen... von Blass, Benjamin E, Fensome, Andrew, Trybulski, Eugene, Magolda, Ronald, Gardell, Stephen J, Liu, Kun, Samuel, Manoj, Feingold, Irene, Huselton, Christine, Jackson, Chris M, Djandjighian, Laurent, Ho, Douglas, Hennan, James, Janusz, John M

Volltext

5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists von Haydar, Simon N, Yun, Heedong, Andrae, Patrick M, Mattes, James, Zhang, Jean, Kramer, Angela, Smith, Deborah L, Huselton, Christine, Graf, Radka, Aschmies, Suzan, Schechter, Lee E, Comery, Thomas A, Robichaud, Albert J

Volltext

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists von Ullrich, John W., Morris, Robert, Bernotas, Ronald C., Travins, Jeremy M., Jetter, James, Unwalla, Rayomand, Quinet, Elaine, Nambi, Ponnal, Feingold, Irene, Huselton, Christine, Enroth, Christofer, Wilhelmsson, Anna, Goos-Nilsson, Annika, Wrobel, Jay

Volltext

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα von Levin, Arthur A, Sturzenbecker, Laurie J, Kazmer, Sonja, Bosakowski, Thomas, Huselton, Christine, Allenby, Gary, Speck, Jeffrey, ratzeisen, Cl, Rosenberger, Michael, Lovey, Allen, Grippo, Joseph F

Volltext

2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor von Pelletier, Jeffrey C., Chengalvala, Murty, Cottom, Josh, Feingold, Irene, Garrick, Lloyd, Green, Daniel, Hauze, Diane, Huselton, Christine, Jetter, James, Kao, Wenling, Kopf, Gregory S., Lundquist, Joseph T., Mann, Charles, Mehlmann, John, Rogers, John, Shanno, Linda, Wrobel, Jay

Volltext

Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles von HEFFERNAN, GavinD, COGHLAN, Richard D, COSMI, Scott A, JOHNSTON, Grace H, KENNEY, Thomas, KOURY, Elizabeth, WINNEKER, Richard C, DEECHER, Darlene C, TRYBULSKI, Eugene J, MANAS, Eric S, MCDEVITT, Robert E, YANFANG LI, MAHANEY, Paige E, ROBICHAUD, Albert J, HUSELTON, Christine, ALFINITO, Peter, BRAY, Jenifer A

Volltext

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators von Hu, Baihua, Jetter, James, Kaufman, David, Singhaus, Robert, Bernotas, Ronald, Unwalla, Rayomand, Quinet, Elaine, Savio, Dawn, Halpern, Anita, Basso, Michael, Keith, James, Clerin, Valerie, Chen, Liang, Liu, Qiang-Yuan, Feingold, Irene, Huselton, Christine, Azam, Farooq, Goos-Nilsson, Annika, Wilhelmsson, Anna, Nambi, Ponnal, Wrobel, Jay

Volltext