Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy von HALL, Adrian, BILLINTON, Andy, NAYLOR, Alan, PASSINGHAM, Barry, WINYARD, Lisa, BROWN, Susan H, CLAYTON, Nicholas M, CHOWDHURY, Anita, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HAYHOW, Thomas G, HURST, David N, KILFORD, Ian R

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Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists von ALLAN, Amanda C, BILLINTON, Andy, NAYLOR, Alan, RAWLINGS, D. Anthony, SIME, Mairi, SCOCCITTI, Tiziana, THEOBALD, Pamela J, BROWN, Susan H, CHOWDHURY, Anita, EATHERTON, Andrew J, FIELDHOUSE, Charlotte, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HALL, Adrian, HURST, David N

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The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing... von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping von HALL, Adrian, BILLINTON, Andy, THEOBALD, Pamela J, BROWN, Susan H, CHOWDHURY, Anita, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HURST, David N, NAYLOR, Alan, PATEL, Sadhana, SCOCCITTI, Tiziana

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Discovery of GSK345931A : An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain von HALL, Adrian, BROWN, Susan H, SCOCCITTI, Tiziana, WILSON, Alexander W, WINCHESTER, Wendy J, BUDD, Christopher, CLAYTON, Nicholas M, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HAYHOW, Thomas G, HURST, David N, NAYLOR, Alan, RAWLINGS, D. Anthony

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)-methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflamma... von HALL, Adrian, BILLINTON, Andy, PEET, Caroline F, SCOCCITTI, Tiziana, WILSON, Alexander W, WINCHESTER, Wendy, BROWN, Susan H, CHOWDHURY, Anita, CLAYTON, Nicholas M, GIBLIN, Gerard M. P, GIBSON, Mairi, GOLDSMITH, Paul A, HURST, David N, NAYLOR, Alan

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The discovery of 6 -[2 -(5 -chloro -2 -{[ (2,4 -difluorophenyl )-methyl ]oxy}phenyl ) -1 -cyclopenten -1 -yl ] -2 -pyridinecarboxylic acid, GW848687X, a potent and selective prosta... von GIBLIN, Gerard M. P, BIT, Rino A, HURST, David N, MICHEL, Anton D, NAYLOR, Alan, NOVELLI, Riccardo, SCOCCITTI, Tiziana, SPALDING, David, TANG, Sac P, WILSON, Alex W, WILSON, Rich, BROWN, Susan H, CHAIGNOT, Hélène M, CHOWDHURY, Anita, CHESSELL, Iain P, CLAYTON, Nicholas M, COLEMAN, Tanya, HALL, Adrian, HAMMOND, Beverley

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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Novel methylene-linked heterocyclic EP1 receptor antagonists von HALL, Adrian, BIT, Rino A, BROWN, Susan H, CHOWDHURY, Anita, GIBLIN, Gerard M. P, HURST, David N, KILFORD, Ian R, LEWELL, Xiao, NAYLOR, Alan, SCOCCITTI, Tiziana

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Discovery of novel biaryl heterocyclic EP1 receptor antagonists von Hall, Adrian, Bit, Rino A., Brown, Susan H., Chaignot, Helene M., Chessell, Iain P., Coleman, Tanya, Giblin, Gerard M.P., Hurst, David N., Kilford, Ian R., Lewell, Xiao Q., Michel, Anton D., Mohamed, Shiyam, Naylor, Alan, Novelli, Riccardo, Skinner, Lee, Spalding, David J., Tang, Sac P., Wilson, Richard J.

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beta.-Adrenoceptor activity of the stereoisomers of the bufuralol alcohol and ketone metabolites von Machin, Peter J, Hurst, David N, Osbond, John M

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Discovery of a novel series of nonacidic benzofuran EP sub(1 receptor antagonists) von Allan, Amanda C, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Eatherton, Andrew J, Fieldhouse, Charlotte, Giblin, Gerard MP, Goldsmith, Paul, Hall, Adrian, Hurst, David N, Naylor, Alan, Rawlings, DAnthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J

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The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing eff... von SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

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Discovery of a novel series of nonacidic benzofuran EP 1 receptor antagonists von Allan, Amanda C., Billinton, Andy, Brown, Susan H., Chowdhury, Anita, Eatherton, Andrew J., Fieldhouse, Charlotte, Giblin, Gerard M.P., Goldsmith, Paul, Hall, Adrian, Hurst, David N., Naylor, Alan, Rawlings, D. Anthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J.

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Synthesis of the potent potassium channel opener Ro 31-6930 via claisen rearrangement and tandem regiocontrolled cyclisation von Attwood, Michael R., Churcher, Ian, Dunsdon, Rachel M., David N, Hurst, Philip S, Jones

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl ]-2-pyrid inecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflamm... von Hall, Adrian, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Clayton, Nicholas M, Giblin, Gerard M P, Gibson, Mairi, Goldsmith, Paul A, Hurst, David N, Naylor, Alan, Peet, Caroline F, Scoccitti, Tiziana, Wilson, Alexander W, Winchester, Wendy

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Discovery of a novel indole series of EP sub(1) receptor antagonists by scaffold hopping von Hall, Adrian, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Goldsmith, Paul, Hurst, David N, Naylor, Alan, Patel, Sadhana, Scoccitti, Tiziana, Theobald, Pamela J

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Novel methylene-linked heterocyclic EP sub(1) receptor antagonists von Hall, Adrian, Bit, Rino A, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Hurst, David N, Kilford, Ian R, Lewell, Xiao, Naylor, Alan, Scoccitti, Tiziana

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Discovery of GSK345931A: An EP 1 receptor antagonist with efficacy in preclinical models of inflammatory pain von Hall, Adrian, Brown, Susan H., Budd, Christopher, Clayton, Nicholas M., Giblin, Gerard M.P., Goldsmith, Paul, Hayhow, Thomas G., Hurst, David N., Naylor, Alan, Anthony Rawlings, D., Scoccitti, Tiziana, Wilson, Alexander W., Winchester, Wendy J.

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP 1 receptor antagonist for the treatment of inflamma... von Hall, Adrian, Billinton, Andy, Brown, Susan H., Chowdhury, Anita, Clayton, Nicholas M., Giblin, Gerard M.P., Gibson, Mairi, Goldsmith, Paul A., Hurst, David N., Naylor, Alan, Peet, Caroline F., Scoccitti, Tiziana, Wilson, Alexander W., Winchester, Wendy

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