A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors von Sohn, Sue J, Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A, Kulagowski, Janusz J, Lewin-Koh, Nicholas, Dengler, Hart S, Johnson, Adam R, Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S, Magnuson, Steven, Wu, Lawren C

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Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors von Hanan, Emily J, van Abbema, Anne, Barrett, Kathy, Blair, Wade S, Blaney, Jeff, Chang, Christine, Eigenbrot, Charles, Flynn, Sean, Gibbons, Paul, Hurley, Christopher A, Kenny, Jane R, Kulagowski, Janusz, Lee, Leslie, Magnuson, Steven R, Morris, Claire, Murray, Jeremy, Pastor, Richard M, Rawson, Tom, Siu, Michael, Ultsch, Mark, Zhou, Aihe, Sampath, Deepak, Lyssikatos, Joseph P

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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling von Zak, Mark, Hanan, Emily J., Lupardus, Patrick, Brown, David G., Robinson, Colin, Siu, Michael, Lyssikatos, Joseph P., Romero, F. Anthony, Zhao, Guiling, Kellar, Terry, Mendonca, Rohan, Ray, Nicholas C., Goodacre, Simon C., Crackett, Peter H., McLean, Neville, Hurley, Christopher A., Yuen, Po-wai, Cheng, Yun-Xing, Liu, Xiongcai, Liimatta, Marya, Kohli, Pawan Bir, Nonomiya, Jim, Salmon, Gary, Buckley, Gerry, Lloyd, Julia, Gibbons, Paul, Ghilardi, Nico, Kenny, Jane R., Johnson, Adam

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Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors von Kulagowski, Janusz J, Blair, Wade, Bull, Richard J, Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K, Hewitt, Peter R, Liimatta, Marya, Hurley, Christopher A, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Bir Kohli, Pawan, Maxey, Robert J, Mendonca, Rohan, Mortara, Kyle, Murray, Jeremy, Narukulla, Raman, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Waszkowycz, Bohdan, Zak, Mark

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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 von Zak, Mark, Hurley, Christopher A, Ward, Stuart I, Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S, Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ellwood, Charles, Gaines, Simon, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Gribling, Peter, Hamman, Chris, Harstad, Eric, Hewitt, Peter, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Labadie, Sharada, Lee, Wyne P, Liao, Jiangpeng, Liimatta, Marya, Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Reeve, Austin, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, van Abbema, Anne, Aliagas, Ignacio, Avitabile-Woo, Barbara, Xiao, Yisong, Yang, Jing, Kulagowski, Janusz J

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors von Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Christopher A., Kenny, Jane R., Cyrus Khojasteh, S., Le, Hoa, Lee, Leslie, Lyssikatos, Joseph P., Magnuson, Steve, Pulk, Rebecca, Tsui, Vickie, Ultsch, Mark, Xiao, Yisong, Zhu, Bing-yan, Sampath, Deepak

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Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 von Zak, Mark, Mendonca, Rohan, Balazs, Mercedesz, Barrett, Kathy, Bergeron, Philippe, Blair, Wade S, Chang, Christine, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Hamman, Chris, Hanan, Emily J, Harstad, Eric, Hewitt, Peter R, Hurley, Christopher A, Jin, Tian, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Kulagowski, Janusz J, Labadie, Sharada, Liao, Jiangpeng, Liimatta, Marya, Lin, Zhonghua, Lupardus, Patrick J, Maxey, Robert J, Murray, Jeremy M, Pulk, Rebecca, Rodriguez, Madeleine, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Xiao, Ling, Xiao, Yisong

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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1 von Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, Adam, Johnson, Tony, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Maxey, Robert J., Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Ubhayakar, Savita, van Abbema, Anne, Ward, Stuart I., Waszkowycz, Bohdan, Zak, Mark

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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2 von Labadie, Sharada, Dragovich, Peter S., Barrett, Kathy, Blair, Wade S., Bergeron, Philippe, Chang, Christine, Deshmukh, Gauri, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Hurley, Christopher A., Johnson, Adam, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Mendonca, Rohan, Murray, Jeremy M., Pulk, Rebecca, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart, Zak, Mark

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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity von Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David

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Biophysical Characterization of an Integrin-Targeted Lipopolyplex Gene Delivery Vector von Mohd Mustapa, M. Firouz, Bell, Paul C, Hurley, Christopher A, Nicol, Alastair, Guénin, Erwann, Sarkar, Supti, Writer, Michele J, Barker, Susie E, Wong, John B, Pilkington-Miksa, Michael A, Papahadjopoulos-Sternberg, Brigitte, Ayazi Shamlou, Parviz, Hailes, Helen C, Hart, Stephen L, Zicha, Daniel, Tabor, Alethea B

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Mannose-pepstatin conjugates as targeted inhibitors of antigen processing von Free, Paul, Hurley, Christopher A, Kageyama, Takashi, Chain, Benjamin M, Tabor, Alethea B

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Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems von Hurley, Christopher A, Wong, John B, Ho, Jimmy, Writer, Michele, Irvine, Scott A, Lawrence, M Jayne, Hart, Stephen L, Tabor, Alethea B, Hailes, Helen C

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Asymmetric Synthesis of Dialkyloxy-3-alkylammonium Cationic Lipids von Hurley, Christopher A, Wong, John B, Hailes, Helen C, Tabor, Alethea B

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The Off-Label Use of POM Wonderful: Using Section 43(a) to Eliminate Misleading Off-Label Drug Promotion von Hurley, Christopher A

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Analysis and Optimization of the Cationic Lipid Component of a Lipid/Peptide Vector Formulation for Enhanced Transfection In Vitro and In Vivo von Writer, Michele, Hurley, Christopher A., Sarkar, Supti, Copeman, Danielle M., Wong, John B., Odlyha, Marianne, Jayne Lawrence, M., Tabor, Alethea B., McAnulty, Robin J., Ayazi Shamlou, Parviz, Hailes, Helen C., Hart, Stephen L.

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Pleated filter element comprising pleated filter media with edge dams, and method of making and using von Li, Fuming B, Sebastian, John M, Krepel, Kenneth J, Legare, Pierre, Hurley, Christopher A, Yeom, Bong Y, Martinson, Paul A

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PLEATED FILTER ELEMENT COMPRISING PLEATED FILTER MEDIA WITH EDGE DAMS, AND METHOD OF MAKING AND USING von LEGARE, Pierre, KREPEL, Kenneth J, SEBASTIAN, John M, LI, Fuming B, MARTINSON, Paul A, HURLEY, Christopher A, YEOM, Bong Y

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에지 댐을 갖는 주름형 필터 매체를 포함하는 주름형 필터 요소, 및 그의 제조 및 사용 방법 von LI FUMING B, MARTINSON PAUL A, HURLEY CHRISTOPHER A, YEOM BONG Y, KREPEL KENNETH J, SEBASTIAN JOHN M, LEGARE PIERRE

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PLEATED FILTER ELEMENT COMPRISING PLEATED FILTER MEDIA WITH EDGE DAMS, AND METHOD OF MAKING AND USING von Li, Fuming B, Sebastian, John M, Krepel, Kenneth J, Legare, Pierre, Hurley, Christopher A, Yeom, Bong Y, Martinson, Paul A

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