Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy von Guertin, Amy D, Li, Jing, Liu, Yaping, Hurd, Melissa S, Schuller, Alwin G, Long, Brian, Hirsch, Heather A, Feldman, Igor, Benita, Yair, Toniatti, Carlo, Zawel, Leigh, Fawell, Stephen E, Gilliland, D Gary, Shumway, Stuart D

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Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1 von Aarts, Marieke, Sharpe, Rachel, Garcia-Murillas, Isaac, Gevensleben, Heidrun, Hurd, Melissa S, Shumway, Stuart D, Toniatti, Carlo, Ashworth, Alan, Turner, Nicholas C

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Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition von Guertin, Amy D, Martin, Melissa M, Roberts, Brian, Hurd, Melissa, Qu, Xianlu, Miselis, Nathan R, Liu, Yaping, Li, Jing, Feldman, Igor, Benita, Yair, Bloecher, Andrew, Toniatti, Carlo, Shumway, Stuart D

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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models von Ellwood-Yen, Katharine, Keilhack, Heike, Kunii, Kaiko, Dolinski, Brian, Connor, Yamicia, Hu, Kun, Nagashima, Kumiko, O'Hare, Erin, Erkul, Yusuf, Di Bacco, Alessandra, Gargano, Diana, Shomer, Nirah H, Angagaw, Minilik, Leccese, Erica, Andrade, Paula, Hurd, Melissa, Shin, Myung K, Vogt, Thomas F, Northrup, Alan, Bobkova, Ekaterina V, Kasibhatla, Shailaja, Bronson, Roderick T, Scott, Martin L, Draetta, Giulio, Richon, Victoria, Kohl, Nancy, Blume-Jensen, Peter, Andersen, Jannik N, Kraus, Manfred

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Peptide-Dependent Recognition of H-2K(b) by Alloreactive Cytotoxic T Lymphocytes von Heath, William, Hurd, Melissa E, Carbone, Francis R, Sherman, Linda A

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Abstract 2051: Inhibitors against CHK1 and WEE1, MK-8776 and MK-1775, strongly synergize in vitro and in vivo to inhibit tumor growth von Shumway, Stuart D., Guertin, Amy D., Martin, Melissa M., Roberts, Brian, Hurd, Melissa S., Qu, Xianlu, Miselis, Nathan R., Bloecher, Andrew, Toniatti, Carlo

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Abstract 2969: A Wee1 kinase inhibitor, MK-1775, sensitizes cervical carcinoma cell lines to cisplatin and topotecan von Shumway, Stuart D., Kubica, Jamie L., Guertin, Amy D., Hurd, Melissa S., Wexler, Roseanne S., Demuth, Tim, Toniatti, Carlo

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I PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models von ELLWOOD-YEN, Katharine, KEILHACK, Heike, GARGANO, Diana, SHOMER, Nirah H, ANGAGAW, Minilik, LECCESE, Erica, ANDRADE, Paula, HURD, Melissa, SHIN, Myung K, VOGT, Thomas F, NORTHRUP, Alan, BOBKOVA, Ekaterina V, KUNII, Kaiko, KASIBHATLA, Shailaja, BRONSON, Roderick T, SCOTT, Martin L, DRAETTA, Giulio, RICHON, Victoria, KOHL, Nancy, BLUME-JENSEN, Peter, ANDERSEN, Jannik N, KRAUS, Manfred, DOLINSKI, Brian, CONNOR, Yamicia, KUN HU, NAGASHIMA, Kumiko, O'HARE, Erin, ERKUL, Yusuf, DI BACCO, Alessandra

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Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype von SPRENT, J, SCHAEFER, M, HURD, M, SURH, C. D, RON, Y

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Establishing school-based mental health services aligned to learning von Hurd, Melissa, Palmiotto, Kim

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Split tolerance in spleen chimeras von Sprent, J, Hurd, M, Schaefer, M, Heath, W

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Profound atrophy of the bone marrow reflecting major histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells von SPRENT, J, SURH, C. D, AGUS, D, HURD, M, SUTTON, S, HEATH, W. R

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Peptide-dependent recognition of H-2K b by alloreactive cytotoxic T lymphocytes von Heath, William R, Hurd, Melissa E, Carbone, Francis R, Sherman, Linda A

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Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes von Heath, W R, Hurd, M E, Carbone, F R, Sherman, L A

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Analysis of novel residues of class I involved in recognition by alloreactive T cells von HEATH, W. R, HURD, M. E, MURRAY, R, FRELINGER, J, SHERMAN, L. A

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Preliminary incidence and trends of infections with pathogens transmitted commonly through food — Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2015–2018 von Tack, Danielle M., Marder, Ellyn P., Griffin, Patricia M., Cieslak, Paul R., Dunn, John, Hurd, Sharon, Scallan, Elaine, Lathrop, Sarah, Muse, Alison, Ryan, Patricia, Smith, Kirk, Tobin-D’Angelo, Melissa, Vugia, Duc J., Holt, Kristin G., Wolpert, Beverly J., Tauxe, Robert, Geissler, Aimee L.

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Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma von Richardson, Paul G., Jacobus, Susanna J., Weller, Edie A., Hassoun, Hani, Lonial, Sagar, Raje, Noopur S., Medvedova, Eva, McCarthy, Philip L., Libby, Edward N., Voorhees, Peter M., Orlowski, Robert Z., Anderson, Larry D., Zonder, Jeffrey A., Milner, Carter P., Gasparetto, Cristina, Agha, Mounzer E., Khan, Abdullah M., Hurd, David D., Gowin, Krisstina, Kamble, Rammurti T., Jagannath, Sundar, Nathwani, Nitya, Alsina, Melissa, Cornell, R. Frank, Hashmi, Hamza, Campagnaro, Erica L., Andreescu, Astrid C., Gentile, Teresa, Liedtke, Michaela, Godby, Kelly N., Cohen, Adam D., Openshaw, Thomas H., Pasquini, Marcelo C., Giralt, Sergio A., Kaufman, Jonathan L., Yee, Andrew J., Scott, Emma, Torka, Pallawi, Foley, Amy, Fulciniti, Mariateresa, Hebert, Kyle, Samur, Mehmet K., Masone, Kelly, Maglio, Michelle E., Zeytoonjian, Andrea A., Nadeem, Omar, Schlossman, Robert L., Laubach, Jacob P., Paba-Prada, Claudia, Ghobrial, Irene M., Perrot, Aurore, Moreau, Philippe, Avet-Loiseau, Hervé, Attal, Michel, Anderson, Kenneth C., Munshi, Nikhil C.

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Salmonellosis Outcomes Differ Substantially by Serotype von Jones, Timothy F., Ingram, L. Amanda, Cieslak, Paul R., Vugia, Duc J., Tobin-D'Angelo, Melissa, Hurd, Sharon, Medus, Carlota, Cronquist, Alicia, Angulo, Frederick J.

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Modelling counterfactual incidence during the transition towards culture-independent diagnostic testing von Healy, Jessica M, Ray, Logan, Tack, Danielle M, Eikmeier, Dana, Tobin-D'Angelo, Melissa, Wilson, Elisha, Hurd, Sharon, Lathrop, Sarah, McGuire, Suzanne M, Bruce, Beau B

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A novel case of cutaneous myxoid spindle cell neoplasm with FMR1‐ALK gene fusion and CD34/S100 co‐expression von Kasago, Israel, Aypar, Umut, Sukhadia, Purvil, Vanderbilt, Chad, Ladanyi, Marc, Hurd, Tierra, Pulitzer, Melissa

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