Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)­sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)­(4-(trifluorome... von Hunt, Hazel J, Belanoff, Joseph K, Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily

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Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation von Viho, Eva M.G., Buurstede, Jacobus C., Mahfouz, Ahmed, Koorneef, Lisa L., van Weert, Lisa T.C.M., Houtman, René, Hunt, Hazel J., Kroon, Jan, Meijer, Onno C.

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The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol von Greenstein, Andrew E., Hunt, Hazel J.

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Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells von Greenstein, Andrew E., Hunt, Hazel J.

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Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals von Vendruscolo, Leandro F, Estey, David, Goodell, Vivian, Macshane, Lauren G, Logrip, Marian L, Schlosburg, Joel E, McGinn, M Adrienne, Zamora-Martinez, Eva R, Belanoff, Joseph K, Hunt, Hazel J, Sanna, Pietro P, George, Olivier, Koob, George F, Edwards, Scott, Mason, Barbara J

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An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes von Custodio, Joseph M., Donaldson, Kirsteen M., Hunt, Hazel J.

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Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition von Viho, Eva M G, Kroon, Jan, Feelders, Richard A, Houtman, René, van den Dungen, Elisabeth S R, Pereira, Alberto M, Hunt, Hazel J, Hofland, Leo J, Meijer, Onno C

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Glucocorticoid receptor modulators decrease alcohol self-administration in male rats von McGinn, M. Adrienne, Tunstall, Brendan J., Schlosburg, Joel E., Gregory-Flores, Adriana, George, Olivier, de Guglielmo, Giordano, Mason, Barbara J., Hunt, Hazel J., Koob, George F., Vendruscolo, Leandro F.

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Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™) von Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R

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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile von Hunt, Hazel J., Belanoff, Joseph K., Golding, Emily, Gourdet, Benoit, Phillips, Timothy, Swift, Denise, Thomas, Jennifer, Unitt, John F., Walters, Iain

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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat von Hunt, Hazel J., Ray, Nicholas C., Hynd, George, Sutton, Jon, Sajad, Mohammed, O’Connor, Elizabeth, Ahmed, Shahadat, Lockey, Peter, Daly, Steve, Buckley, Gerry, Clark, Robin D., Roe, Robert, Blasey, Christine, Belanoff, Joe

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SAT-224 Pharmacokinetics of the selective glucocorticoid receptor modulator miricorilant in healthy volunteers and patients with presumed metabolic dysfunction-associated steatohep... von Custodio, Joseph M., Donaldson, Kirsteen, Kunta, Jeevan, Juneja, Kavita, Alkhouri, Naim, Hunt, Hazel J.

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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity von Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David

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Identification of the Clinical Candidate ( R )-(1-(4-Fluorophenyl)-6-((1-methyl-1 H -pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1 H -pyrazolo[3,4- g ]isoquinolin-4a-yl)(4-(trifl... von Hunt, Hazel J., Belanoff, Joseph K., Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily

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Abstract 3434: Selective glucocorticoid receptor modulation reveals a new role for CLEC10A in patients with solid tumors von Colombo, Nicoletta, Van Gorp, Toon, Matulonis, Ursula A., Oaknin, Ana, Grisham, Rachel N., Provencher, Diane, Fleming, Gini F., Olawaiye, Alexander B., Borazanci, Erkut H., Szmulewitz, Russell Z., Wadekar, Subhagya A., Mann, Grace, Hunt, Hazel J., Greenstein, Andrew E., Lorusso, Domenica

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Selection and early clinical evaluation of the brain-penetrant 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) inhibitor UE2343 (Xanamem(TM)) von Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R

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2,6-substituert-4-monosubstituert aminopyrimidin som prostaglandin D2 reseptorantagonister og farmasøytiske sammensetninger inneholdene disse, samt anvendelse av disse for fremstil... von Gillespy, Timothy Alan, Dechaux, Elsa, Lim, Sungtaek, Cao, Bin, Boffey, Ray, Harris, Keith John, Aguiar, Joacy C, Hunt, Hazel J, Stefany, David, Gardner, Charles J

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ChemInform Abstract: Silicon Diols: Effective Inhibitors of Human Leukocyte Elastase von Showell, Graham A., Montana, John G., Chadwick, Jenny A., Higgs, Chris, Hunt, Hazel J., MacKenzie, Robert E., Price, Steve, Wilkinson, Tina J.

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2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists von LIM SUNGTAEK,HARRIS KEITH JOHN,STEFANY DAVID,GARDNER CHARLES J.,CAO BIN,BOFFEY RAY,GILLESPY TIMOTHYA.,AGUIAR JOACY C.,HUNT HAZEL J.,DECHAUX ELSA A

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2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS von GARDNER, CHARLES J, CAO, BIN, BOFFEY, RAY, AGUIAR, JOACY C, DECHAUX, ELSA A, GILLESPY, TIMOTHY A, HUNT, HAZEL J, HARRIS, KEITH JOHN, LIM, SUNGTAEK, STEFANY, DAVID

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