NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components von Doyle, Sarah L, Campbell, Matthew, Ozaki, Ema, Salomon, Robert G, Mori, Andres, Kenna, Paul F, Farrar, Gwyneth Jane, Kiang, Anna-Sophia, Humphries, Marian M, Lavelle, Ed C, O'Neill, Luke A J, Hollyfield, Joe G, Humphries, Peter

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Blood–Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy von Doherty, Colin P., O’Keefe, Eoin, Wallace, Eugene, Loftus, Teresa, Keaney, James, Kealy, John, Humphries, Marian M., Molloy, Michael G., Meaney, James F., Farrell, Michael, Campbell, Matthew

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Activation of Bax in three models of retinitis pigmentosa von Comitato, Antonella, Sanges, Daniela, Rossi, Alessandra, Humphries, Marian M, Marigo, Valeria

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RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models von Millington-Ward, Sophia, Chadderton, Naomi, Finnegan, Laura K, Post, Iris J M, Carrigan, Matthew, Nixon, Rachel, Humphries, Marian M, Humphries, Pete, Kenna, Paul F, Palfi, Arpad, Farrar, G Jane

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Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma von O'Callaghan, Jeffrey, Crosbie, Darragh E, Cassidy, Paul S, Sherwood, Joseph M, Flügel-Koch, Cassandra, Lütjen-Drecoll, Elke, Humphries, Marian M, Reina-Torres, Ester, Wallace, Deborah, Kiang, Anna-Sophia, Campbell, Matthew, Stamer, W Daniel, Overby, Darryl R, O'Brien, Colm, Tam, Lawrence C S, Humphries, Peter

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Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury von Campbell, Matthew, Hanrahan, Finnian, Gobbo, Oliviero L., Kelly, Michael E., Kiang, Anna-Sophia, Humphries, Marian M., Nguyen, Anh T.H., Ozaki, Ema, Keaney, James, Blau, Christoph W., Kerskens, Christian M., Cahalan, Stephen D., Callanan, John J., Wallace, Eugene, Grant, Gerald A., Doherty, Colin P., Humphries, Peter

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Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa von Millington-Ward, Sophia, Chadderton, Naomi, O'Reilly, Mary, Palfi, Arpad, Goldmann, Tobias, Kilty, Claire, Humphries, Marian, Wolfrum, Uwe, Bennett, Jean, Humphries, Peter, Kenna, Paul F, Farrar, G Jane

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RNA Interference–Mediated Suppression and Replacement of Human Rhodopsin In Vivo von O’Reilly, Mary, Palfi, Arpad, Chadderton, Naomi, Millington-Ward, Sophia, Ader, Marius, Cronin, Thérèse, Tuohy, Thérèse, Auricchio, Alberto, Hildinger, Markus, Tivnan, Amanda, McNally, Niamh, Humphries, Marian M., Kiang, Anna-Sophia, Humphries, Pete, Kenna, Paul F., Farrar, G. Jane

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Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm’s Canal Endothelia von Tam, Lawrence C. S., Reina-Torres, Ester, Sherwood, Joseph M., Cassidy, Paul S., Crosbie, Darragh E., Lütjen-Drecoll, Elke, Flügel-Koch, Cassandra, Perkumas, Kristin, Humphries, Marian M., Kiang, Anna-Sophia, O’Callaghan, Jeffrey, Callanan, John J., Read, A. Thomas, Ethier, C. Ross, O’Brien, Colm, Lawrence, Matthew, Campbell, Matthew, Stamer, W. Daniel, Overby, Darryl R., Humphries, Pete

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Improved Retinal Function in a Mouse Model of Dominant Retinitis Pigmentosa Following AAV-delivered Gene Therapy von Chadderton, Naomi, Millington-Ward, Sophia, Palfi, Arpad, O'Reilly, Mary, Tuohy, Gearóid, Humphries, Marian M, Li, Tiansen, Humphries, Peter, Kenna, Paul F, Farrar, G Jane

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SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration von Ozaki, Ema, Gibbons, Luke, Neto, Nuno G. B., Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew, Doyle, Sarah L.

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Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier von Keaney, James, Walsh, Dominic M, O'Malley, Tiernan, Hudson, Natalie, Crosbie, Darragh E, Loftus, Teresa, Sheehan, Florike, McDaid, Jacqueline, Humphries, Marian M, Callanan, John J, Brett, Francesca M, Farrell, Michael A, Humphries, Peter, Campbell, Matthew

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A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement von BOWNE, Sara J, HUMPHRIES, Marian M, FULTON, Robert S, SODERGREN, Erica J, ALLMAN, Denis, MILLINGTON-WARD, Sophia, PALFI, Arpad, MCKEE, Alex, BLANTON, Susan H, SLIFER, Susan, KONIDARI, Loanna, FARRAR, G. Jane, SULLIVAN, Lori S, DAIGER, Stephen P, HUMPHRIES, Peter, KENNA, Paul F, TAM, Lawrence Cs, KIANG, Anna S, CAMPBELL, Matthew, WEINSTOCK, George M, KOBOLDT, Daniel C, LI DING

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siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model von Cassidy, Paul S., Kelly, Ruth A., Reina-Torres, Ester, Sherwood, Joseph M., Humphries, Marian M., Kiang, Anna-Sophia, Farrar, G. Jane, O’Brien, Colm, Campbell, Matthew, Stamer, W. Daniel, Overby, Darryl R., Humphries, Pete, O’Callaghan, Jeffrey

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experimental platform for systemic drug delivery to the retina von Campbell, Matthew, Nguyen, Anh T.H, Kiang, Anna-Sophia, Tam, Lawrence C.S, Gobbo, Oliviero L, Kerskens, Christian, Dhubhghaill, Sorcha Ni, Humphries, Marian M, Farrar, G.-Jane, Kenna, Paul F, Humphries, Peter

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AAV‐mediated gene therapy improving mitochondrial function provides benefit in age‐related macular degeneration models von Millington‐Ward, Sophia, Chadderton, Naomi, Finnegan, Laura K., Post, Iris J.M., Carrigan, Matthew, Gardiner, Tom, Peixoto, Elisa, Maloney, Daniel, Humphries, Marian M., Stitt, Alan, Léveillard, Thierry, Humphries, Pete, Kenna, Paul F., Palfi, Arpad, Farrar, G. Jane

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Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy von Hudson, Natalie, Celkova, Lucia, Hopkins, Alan, Greene, Chris, Storti, Federica, Ozaki, Ema, Fahey, Erin, Theodoropoulou, Sofia, Kenna, Paul F, Humphries, Marian M, Curtis, Annie M, Demmons, Eleanor, Browne, Akeem, Liddie, Shervin, Lawrence, Matthew S, Grimm, Christian, Cahill, Mark T, Humphries, Pete, Doyle, Sarah L, Campbell, Matthew

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Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy von Kenna, Paul F, Humphries, Marian M, Kiang, Anna-Sophia, Brabet, Philippe, Guillou, Laurent, Ozaki, Ema, Campbell, Matthew, Farrar, G Jane, Koenekoop, Robert, Humphries, Pete

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Properties and Therapeutic Implications of an Enigmatic D477G RPE65 Variant Associated with Autosomal Dominant Retinitis Pigmentosa von Kiang, Anna-Sophia, Kenna, Paul F., Humphries, Marian M., Ozaki, Ema, Koenekoop, Robert K., Campbell, Matthew, Farrar, G. Jane, Humphries, Pete

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Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90) von Tam, Lawrence C.S., Kiang, Anna-Sophia, Campbell, Matthew, Keaney, James, Jane Farrar, G., Humphries, Marian M., Kenna, Paul F., Humphries, Pete

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