Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 von Pike, Kurt G., Malagu, Karine, Hummersone, Marc G., Menear, Keith A., Duggan, Heather M.E., Gomez, Sylvie, Martin, Niall M.B., Ruston, Linette, Pass, Sarah L., Pass, Martin

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion von Golding, Sarah E, Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F, Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A, O'Connor, Mark J, Povirk, Lawrence F, van Meter, Timothy, Valerie, Kristoffer

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The chemistry and biology of the bryostatin antitumour macrolides von Hale, Karl J, Hummersone, Marc G, Manaviazar, Soraya, Frigerio, Mark

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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J

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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts von Iachettini, Sara, Stevens, Malcolm Fg, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D'Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D'Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica

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Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7 von Manaviazar, Soraya, Frigerio, Mark, Bhatia, Gurpreet S, Hummersone, Marc G, Aliev, Abil E, Hale, Karl J

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines von Cousin, David, Zhang, Jihong, Hummersone, Marc G., Matthews, Charles S., Frigerio, Mark, Bradshaw, Tracey D., Stevens, Malcolm F. G.

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Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and... von Hollick, Jonathan J, Rigoreau, Laurent J. M, Cano-Soumillac, Celine, Cockcroft, Xiaoling, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Hickson, Ian, Hummersone, Marc G, Menear, Keith A, Martin, Niall M. B, Matthews, Ian, Newell, David R, Ord, Rachel, Richardson, Caroline J, Smith, Graeme C. M, Griffin, Roger J

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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype von Cano, Céline, Barbeau, Olivier R, Bailey, Christine, Cockcroft, Xiao-Ling, Curtin, Nicola J, Duggan, Heather, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Knights, Charlotte, Menear, Keith A, Newell, David R, Richardson, Caroline J, Smith, Graeme C. M, Spittle, Ben, Griffin, Roger J

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Synthesis and growth-inhibitory activities of imidazo[5,1- d ]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hete... von Cousin, David, Hummersone, Marc G, Bradshaw, Tracey D, Zhang, Jihong, Moody, Christopher J, Foreiter, Magdalena B, Summers, Helen S, Lewis, William, Wheelhouse, Richard T, Stevens, Malcolm F G

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity von CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia

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Abstract A131: Drugging the telomere: A rational approach for the selection quadruplex DNA targeting agents for the treatment of cancer von Hummersone, Marc G.

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Synthesis of a Simplified Bryostatin C-Ring Analogue That Binds to the CRD2 of Human PKC-α and Construction of a Novel BC-Analogue by an Unusual Julia Olefination Process von Hale, Karl J, Frigerio, Mark, Manaviazar, Soraya, Hummersone, Marc G, Fillingham, Ian J, Barsukov, Igor G, Damblon, Christian F, Gescher, Andreas, Roberts, Gordon C. K

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Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities von Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, Porru, Manuela, Artuso, Simona, Stevens, Malcolm, Hummersone, Marc, Biroccio, Annamaria, Salvati, Erica, Leonetti, Carlo

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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.

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N3-Substituted Temozolomide Analogs Overcome Methylguanine-DNA Methyltransferase and Mismatch Repair Precipitating Apoptotic and Autophagic Cancer Cell Death von Zhang, Jihong, Hummersone, Marc, Matthews, Charles S., Stevens, Malcolm F.G., Bradshaw, Tracey D.

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The discovery and optimisation of pyrido[2,3- d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase von Malagu, Karine, Duggan, Heather, Menear, Keith, Hummersone, Marc, Gomez, Sylvie, Bailey, Christine, Edwards, Peter, Drzewiecki, Jan, Leroux, Frédéric, Quesada, Mar Jimenez, Hermann, Gesine, Maine, Stephanie, Molyneaux, Carrie-Anne, Le Gall, Armelle, Pullen, James, Hickson, Ian, Smith, Lisa, Maguire, Sharon, Martin, Niall, Smith, Graeme, Pass, Martin

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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hetero... von Cousin, David, Hummersone, Marc G, Bradshaw, Tracey D, Zhang, Jihong, Moody, Christopher J, Foreiter, Magdalena B, Summers, Helen S, Lewis, William, Wheelhouse, Richard T, Stevens, Malcolm F. G

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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and hetero... von Cousin, David, Hummersone, Marc G., Bradshaw, Tracey D., Zhang, Jihong, Moody, Christopher J., Foreiter, Magdalena B., Summers, Helen S., Lewis, William, Wheelhouse, Richard T., Stevens, Malcolm F. G.

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell linesPart 43 in the series 'Antitumour Imidazotetra... von Cousin, David, Zhang, Jihong, Hummersone, Marc G, Matthews, Charles S, Frigerio, Mark, Bradshaw, Tracey D, Stevens, Malcolm F. G

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