Practical chiral alcohol manufacture using ketoreductases von Huisman, Gjalt W, Liang, Jack, Krebber, Anke

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On the development of new biocatalytic processes for practical pharmaceutical synthesis von Huisman, Gjalt W, Collier, Steven J

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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture von Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.

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Origins of stereoselectivity in evolved ketoreductases von Noey, Elizabeth L., Tibrewal, Nidhi, Jiménez-Osés, Gonzalo, Osuna, Sílvia, Park, Jiyong, Bond, Carly M., Cascio, Duilio, Liang, Jack, Zhang, Xiyun, Huisman, Gjalt W., Tang, Yi, Houk, Kendall N.

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Adapting protein sequences for optimized therapeutic efficacy von Dellas, Nikki, Liu, Joyce, Botham, Rachel C., Huisman, Gjalt W.

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A green-by-design biocatalytic process for atorvastatin intermediate von Ma, Steven K, Gruber, John, Davis, Chris, Newman, Lisa, Gray, David, Wang, Alica, Grate, John, Huisman, Gjalt W, Sheldon, Roger A

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The role of distant mutations and allosteric regulation on LovD active site dynamics von Jiménez-Osés, Gonzalo, Osuna, Sílvia, Gao, Xue, Sawaya, Michael R, Gilson, Lynne, Collier, Steven J, Huisman, Gjalt W, Yeates, Todd O, Tang, Yi, Houk, K N

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Optimizing human α-galactosidase for treatment of Fabry disease von Hallows, William C., Skvorak, Kristen, Agard, Nick, Kruse, Nikki, Zhang, Xiyun, Zhu, Yu, Botham, Rachel C., Chng, Chinping, Shukla, Charu, Lao, Jessica, Miller, Mathew, Sero, Antoinette, Viduya, Judy, Ismaili, Moulay Hicham Alaoui, McCluskie, Kerryn, Schiffmann, Raphael, Silverman, Adam P., Shen, Jin-Song, Huisman, Gjalt W.

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Improving catalytic function by ProSAR-driven enzyme evolution von Huisman, Gjalt W, Fox, Richard J, Davis, S Christopher, Mundorff, Emily C, Newman, Lisa M, Gavrilovic, Vesna, Ma, Steven K, Chung, Loleta M, Ching, Charlene, Tam, Sarena, Muley, Sheela, Grate, John, Gruber, John, Whitman, John C, Sheldon, Roger A

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Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization von Li, Tao, Liang, Jack, Ambrogelly, Alexandre, Brennan, Tim, Gloor, Guy, Huisman, Gjalt, Lalonde, James, Lekhal, Azzeddine, Mijts, Ben, Muley, Sheela, Newman, Lisa, Tobin, Matt, Wong, George, Zaks, Aleksey, Zhang, Xiyun

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Enzyme optimization: moving from blind evolution to statistical exploration of sequence–function space von Fox, Richard J, Huisman, Gjalt W

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Enzyme evolution for industrial biocatalytic cascades von Nazor, Jovana, Liu, Joyce, Huisman, Gjalt

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Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol von Liang, Jack, Mundorff, Emily, Voladri, Rama, Jenne, Stephan, Gilson, Lynne, Conway, Aaron, Krebber, Anke, Wong, John, Huisman, Gjalt, Truesdell, Susan, Lalonde, James

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Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)‑Licarbazepine Using an Evolved Ketoreductase von Modukuru, Naga K, Sukumaran, Joly, Collier, Steven J, Chan, Ann Shu, Gohel, Anupam, Huisman, Gjalt W, Keledjian, Raquel, Narayanaswamy, Karthik, Novick, Scott J, Palanivel, S. M, Smith, Derek, Wei, Zhang, Wong, Brian, Yeo, Wan Lin, Entwistle, David A

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Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic von MADISON, L. L, HUISMAN, G. W

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Asymmetric Carbonyl Reductions with Microbial Ketoreductases von Sorgedrager, Menno J., van Rantwijk, Fred, Huisman, Gjalt W., Sheldon, Roger A.

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Directed Evolution and Biocatalysis von Powell, Keith A., Ramer, Sandra W., del Cardayré, Stephen B., Stemmer, Willem P. C., Tobin, Matthew B., Longchamp, Pascal F., Huisman, Gjalt W.

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Towards novel processes for the fine-chemical and pharmaceutical industries von Huisman, Gjalt W, Gray, David

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Directed evolution: the ‘rational’ basis for ‘irrational’ design von Tobin, Matthew B, Gustafsson, Claes, Huisman, Gjalt W

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Sensing Starvation: A Homoserine Lactone-Dependent Signaling Pathway in Escherichia coli von Huisman, Gjalt W., Kolter, Roberto

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