Brigatinib Versus Crizotinib in ALK Inhibitor–Naive Advanced ALK-Positive NSCLC: Final Results of Phase 3 ALTA-1L Trial von Camidge, D. Ross, Kim, Hye Ryun, Ahn, Myung-Ju, Yang, James C.H., Han, Ji-Youn, Hochmair, Maximilian J., Lee, Ki Hyeong, Delmonte, Angelo, Garcia Campelo, Maria Rosario, Kim, Dong-Wan, Griesinger, Frank, Felip, Enriqueta, Califano, Raffaele, Spira, Alexander I., Gettinger, Scott N., Tiseo, Marcello, Lin, Huamao M., Liu, Yuyin, Vranceanu, Florin, Niu, Huifeng, Zhang, Pingkuan, Popat, Sanjay

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Design of the parallel mechanism for a hybrid mobile robot in wind turbine blades polishing von Chong, Zenghui, Xie, Fugui, Liu, Xin-Jun, Wang, Jinsong, Niu, Huifeng

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CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade von Morita, Tomoko Yamamori, Yu, Jie, Kashima, Yukie, Kamata, Ryo, Yamamoto, Gaku, Minamide, Tatsunori, Mashima, Chiaki, Yoshiya, Miyuki, Sakae, Yuta, Yamauchi, Toyohiro, Hakozaki, Yumi, Kageyama, Shun-ichiro, Nakamura, Akito, Lightcap, Eric, Tanaka, Kosuke, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro

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RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis von Brünker, Peter, Wartha, Katharina, Friess, Thomas, Grau-Richards, Sandra, Waldhauer, Inja, Koller, Claudia Ferrara, Weiser, Barbara, Majety, Meher, Runza, Valeria, Niu, Huifeng, Packman, Kathryn, Feng, Ningping, Daouti, Sherif, Hosse, Ralf J, Mössner, Ekkehard, Weber, Thomas G, Herting, Frank, Scheuer, Werner, Sade, Hadassah, Shao, Cuiying, Liu, Bin, Wang, Peng, Xu, Gary, Vega-Harring, Suzana, Klein, Christian, Bosslet, Klaus, Umaña, Pablo

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Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer von Niu, Huifeng, Manfredi, Mark, Ecsedy, Jeffrey A

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Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-Raf V600E Mutation von HUISHENG WANG, DAOUTI, Sherif, HUIFENG NIU, LI, Wen-Hui, YANG WEN, RIZZO, Christine, HIGGINS, Brian, PACKMAN, Kathryn, ROSEN, Neal, BOYLAN, John F, HEIMBROOK, David

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines von Chen, Brenden, Tardell, Christine, Higgins, Brian, Packman, Kathryn, Boylan, John F, Niu, Huifeng

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Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia von Kelly, Kevin R., Shea, Thomas C., Goy, André, Berdeja, Jesus G., Reeder, Craig B., McDonagh, Kevin T., Zhou, Xiaofei, Danaee, Hadi, Liu, Hua, Ecsedy, Jeffrey A., Niu, Huifeng, Benaim, Ely, Padmanabhan Iyer, Swaminathan

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Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor von Iwai, Kenichi, Nambu, Tadahiro, Dairiki, Ryo, Ohori, Momoko, Yu, Jie, Burke, Kristine, Gotou, Masamitsu, Yamamoto, Yukiko, Ebara, Shunsuke, Shibata, Sachio, Hibino, Ryosuke, Nishizawa, Satoru, Miyazaki, Tohru, Homma, Misaki, Oguro, Yuya, Imada, Takashi, Cho, Nobuo, Uchiyama, Noriko, Kogame, Akifumi, Takeuchi, Toshiyuki, Kurasawa, Osamu, Yamanaka, Kazunori, Niu, Huifeng, Ohashi, Akihiro

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Tracking CD40 signaling during germinal center development von Basso, Katia, Klein, Ulf, Niu, Huifeng, Stolovitzky, Gustavo A., Tu, Yuhai, Califano, Andrea, Cattoretti, Giorgio, Dalla-Favera, Riccardo

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A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery von Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro

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BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells von Niu, Huifeng, Cattoretti, Giorgio, Dalla-Favera, Riccardo

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor von Niu, H, Ye, B H, Dalla-Favera, R

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A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage von DAOUTI, Sherif, LI, Wen-Hui, HONGJIN BIAN, REIDHAAR-OLSON, John F, BLISS, Sarah A, OLIVIER, Andree R, SERGI, Joseph A, FRY, David, DANHO, Waleed, RITLAND, Steve, FOTOUHI, Nader, HEIMBROOK, David, HONG QIAN, HUIFENG NIU, HUANG, Kuo-Sen, HOLMGREN, Janna, LEVIN, Wayne, REIK, Linda, MCGADY, Debra Lucas, GILLESPIE, Paul, PERROTTA, Agostino

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Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A... von Niu, Huifeng, Shin, Hyunjin, Gao, Feng, Zhang, Jacob, Bahamon, Brittany, Danaee, Hadi, Melichar, Bohuslav, Schilder, Russell J., Coleman, Robert L., Falchook, Gerald, Adenis, Antoine, Behbakht, Kian, DeMichele, Angela, Dees, Elizabeth Claire, Perez, Kimberly, Matulonis, Ursula, Sawrycki, Piotr, Huebner, Dirk, Ecsedy, Jeffrey

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The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker von LEE, Lucy, HUIFENG NIU, GOELZER, Petra, DE SCHEPPER, Stefanie, YOSHIMURA, Yashushi, BARRETT, Joanne, ISHIKAWA, Yuji, WEISSGERBER, Georges, PECK, Richard, RUEGER, Ruediger, IGAWA, Yuriko, DEUTSCH, Jonathan, ISHII, Nobuya, SONG MU, SAKAMOTO, Yuuichiro, BUSSE-REID, Rachel, GIMMI, Claude

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Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer Therapy von DAOUTI, Sherif, HUISHENG WANG, QING XIANG, PODLASKI, Frank J, YANG HE, FOTOUHI, Nader, HEIMBROOK, David, HUIFENG NIU, LI, Wen-Hui, HIGGINS, Brian, KOLINSKY, Kenneth, PACKMAN, Kathryn, SPECIAN, Anthony, KONG, Norman, HUBY, Nicholas, YANG WEN

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Molecular Pathogenesis of Non-Hodgkin's Lymphoma: the Role of Bcl-6 von Pasqualucci, Laura, Bereschenko, Oxana, Niu, Huifeng, Klein, Ulf, Basso, Katia, Guglielmino, Roberta, Cattoretti, Giorgio, Dalla-Favera, Riccardo

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The proto-oncogene BCL-6 in normal and malignant B cell development von Niu, Huifeng

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Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation von Wang, Huisheng, Daouti, Sherif, Li, Wen-Hui, Wen, Yang, Rizzo, Christine, Higgins, Brian, Packman, Kathryn, Rosen, Neal, Boylan, John F, Heimbrook, David, Niu, Huifeng

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