Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid von Carbone, Marco, Mells, George F, Pells, Greta, Dawwas, Muhammad F, Newton, Julia L, Heneghan, Michael A, Neuberger, James M, Day, Darren B, Ducker, Samantha J, Sandford, Richard N, Alexander, Graeme J, Jones, David E.J

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Detection of Planetary and Stellar Companions to Neighboring Stars via a Combination of Radial Velocity and Direct Imaging Techniques von Kane, Stephen R., Dalba, Paul A., Li, Zhexing, Horch, Elliott P., Hirsch, Lea A., Horner, Jonathan, Wittenmyer, Robert A., Howell, Steve B., Everett, Mark E., Butler, R. Paul, Tinney, Christopher G., Carter, Brad D., Wright, Duncan J., Jones, Hugh R. A., Bailey, Jeremy, O'Toole, Simon J.

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Evaluating the sensitivity of radical chemistry and ozone formation to ambient VOCs and NOx in Beijing von Whalley, Lisa K, Slater, Eloise J, Woodward-Massey, Robert, Ye, Chunxiang, Lee, James D, Squires, Freya, Hopkins, James R, Dunmore, Rachel E, Shaw, Marvin, Hamilton, Jacqueline F, Lewis, Alastair C, Mehra, Archit, Worrall, Stephen D, Asan Bacak, Bannan, Thomas J, Coe, Hugh, Percival, Carl J, Ouyang, Bin, Jones, Roderic L, Crilley, Leigh R, Kramer, Louisa J, Bloss, William J, Vu, Tuan, Kotthaus, Simone, Grimmond, Sue, Sun, Yele, Xu, Weiqi, Siyao Yue, Ren, Lujie, Acton, W Joe F, Hewitt, C Nicholas, Wang, Xinming, Fu, Pingqing, Heard, Dwayne E

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Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis von Mells, George F, Floyd, James A B, Morley, Katherine I, Cordell, Heather J, Franklin, Christopher S, Shin, So-Youn, Heneghan, Michael A, Neuberger, James M, Donaldson, Peter T, Day, Darren B, Ducker, Samantha J, Muriithi, Agnes W, Wheater, Elizabeth F, Hammond, Christopher J, Dawwas, Muhammad F, Jones, David E, Peltonen, Leena, Alexander, Graeme J, Sandford, Richard N, Anderson, Carl A

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Investigating the chemical impurity profiles of fentanyl preparations and precursors to identify chemical attribution signatures for synthetic method attribution von Ovenden, Simon P.B., McDowall, Lyndal J., McKeown, Hugh E., McGill, Nathan W., Jones, Oliver A.H., Pearson, James R., Petricevic, Marija, Rogers, Michael L., Rook, Trevor J., Williams, Jilliarne, Webster, Renée L., Zanatta, Shannon D.

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Managing the challenge of chemically reactive metabolites in drug development von Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A

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The Why, What, and How of Global Biodiversity Indicators Beyond the 2010 Target von JONES, JULIA P. G., COLLEN, BEN, ATKINSON, GILES, BAXTER, PETER W. J., BUBB, PHILIP, ILLIAN, JANINE B., KATZNER, TODD E., KEANE, AIDAN, LOH, JONATHAN, MCDONALD-MADDEN, EVE, NICHOLSON, EMILY, PEREIRA, HENRIQUE M., POSSINGHAM, HUGH P., PULLIN, ANDREW S., RODRIGUES, ANA S. L., RUIZ-GUTIERREZ, VIVIANA, SOMMERVILLE, MATTHEW, MILNER-GULLAND, E. J.

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Two planets around Kapteyn's star: a cold and a temperate super-Earth orbiting the nearest halo red dwarf von Anglada-Escudé, G., Arriagada, P., Tuomi, M., Zechmeister, M., Jenkins, J. S., Ofir, A., Dreizler, S., Gerlach, E., Marvin, C. J., Reiners, A., Jeffers, S. V., Butler, R. P., Vogt, S. S., Amado, P. J., Rodríguez-López, C., Berdiñas, Z. M., Morin, J., Crane, J. D., Shectman, S. A., Thompson, I. B., Díaz, M., Rivera, E., Sarmiento, L. F., Jones, H. R. A.

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Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation von Reddy, Vivek Y., Gerstenfeld, Edward P., Natale, Andrea, Whang, William, Cuoco, Frank A., Patel, Chinmay, Mountantonakis, Stavros E., Gibson, Douglas N., Harding, John D., Ellis, Christopher R., Ellenbogen, Kenneth A., DeLurgio, David B., Osorio, Jose, Achyutha, Anitha B., Schneider, Christopher W., Mugglin, Andrew S., Albrecht, Elizabeth M., Stein, Kenneth M., Lehmann, John W., Mansour, Moussa

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data von Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert

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The Lancet Global Health Commission on Global Eye Health: vision beyond 2020 von Burton, Matthew J, Ramke, Jacqueline, Marques, Ana Patricia, Bourne, Rupert R A, Congdon, Nathan, Jones, Iain, Ah Tong, Brandon A M, Arunga, Simon, Bachani, Damodar, Bascaran, Covadonga, Bastawrous, Andrew, Blanchet, Karl, Braithwaite, Tasanee, Buchan, John C, Cairns, John, Cama, Anasaini, Chagunda, Margarida, Chuluunkhuu, Chimgee, Cooper, Andrew, Crofts-Lawrence, Jessica, Dean, William H, Denniston, Alastair K, Ehrlich, Joshua R, Emerson, Paul M, Evans, Jennifer R, Frick, Kevin D, Friedman, David S, Furtado, João M, Gichangi, Michael M, Gichuhi, Stephen, Gilbert, Suzanne S, Gurung, Reeta, Habtamu, Esmael, Holland, Peter, Jonas, Jost B, Keane, Pearse A, Keay, Lisa, Khanna, Rohit C, Khaw, Peng Tee, Kuper, Hannah, Kyari, Fatima, Lansingh, Van C, Mactaggart, Islay, Mafwiri, Milka M, Mathenge, Wanjiku, McCormick, Ian, Morjaria, Priya, Mowatt, Lizette, Muirhead, Debbie, Murthy, Gudlavalleti V S, Mwangi, Nyawira, Patel, Daksha B, Peto, Tunde, Qureshi, Babar M, Salomão, Solange R, Sarah, Virginia, Shilio, Bernadetha R, Solomon, Anthony W, Swenor, Bonnielin K, Taylor, Hugh R, Wang, Ningli, Webson, Aubrey, West, Sheila K, Wong, Tien Yin, Wormald, Richard, Yasmin, Sumrana, Yusufu, Mayinuer, Silva, Juan Carlos, Resnikoff, Serge, Ravilla, Thulasiraj, Gilbert, Clare E, Foster, Allen, Faal, Hannah B

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New insights into the genetic etiology of Alzheimer’s disease and related dementias von Holmans, Peter A., de Rojas, Itziar, Bis, Joshua C., Alarcón-Martín, Emilio, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Álvarez, Victoria, Antúnez, Carmen, Arosio, Beatrice, Athanasiu, Lavinia, Banaj, Nerisa, Below, Jennifer E., Benussi, Luisa, Bossù, Paola, Burholt, Vanessa, Calero, Miguel, Cervera-Carles, Laura, Chen, Hung-Hsin, Custodero, Carlo, de Paiva Lopes, Katia, DeStefano, Anita, Dichgans, Martin, Diehl-Schmid, Janine, Duron, Emmanuelle, Dufouil, Carole, Espinosa, Ana, Nielsen, Sune Fallgaard, Fenoglio, Chiara, Ferrari, Raffaele, Fox, Nick C., Frank-García, Ana, Galimberti, Daniela, Grande, Giulia, Green, Emma, Grünblatt, Edna, Grunin, Michelle, Gudnason, Vilmundur, Hampel, Harald, Hausner, Lucrezia, Hulsman, Marc, Kivipelto, Miia, Kornhuber, Johannes, Kuzma, Amanda B., Launer, Lenore, Ma, Yiyi, Maier, Wolfgang, Montes, Angel Martín, Masullo, Carlo, Mendoza, Silvia, Moebus, Susanne, Morgan, Kevin, Muchnik, Carolina, Mukherjee, Shubhabrata, Nacmias, Benedetta, Ngandu, Tiia, Nicolas, Gael, Nordestgaard, Børge G., Ortega, Gemma, Paolo, Caffarra, Papenberg, Goran, Peloso, Gina, Pérez-Cordón, Alba, Pérez-Tur, Jordi, Pineda, Juan A., Pisanu, Claudia, Polak, Thomas, Quintela, Inés, Rábano, Alberto, Reinders, Marcel J. T., Riedel-Heller, Steffi, Rubino, Elisa, Rujescu, Dan, Sanabria, Ángela, Sánchez-Valle, Raquel, Satizabal, Claudia L., Scarpini, Elio, Scheltens, Philip, Schmid, Matthias, Schneider, Anja, Serrano, Manuel, Solomon, Alina, Song, Yeunjoo, Spalletta, Gianfranco, Squassina, Alessio, Stordal, Eystein, Tartan, Juan Pablo, Tárraga, Lluís, Thomas, Tegos, Tosto, Giuseppe, Wallon, David, Wang, Li-San, Weinhold, Leonie, Wiltfang, Jens, Zare, Habil, Farrer, Lindsay A., Psaty, Bruce M., Williams, Julie, Frikke-Schmidt, Ruth, Deleuze, Jean-François

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Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease von Clarke, Robert, Peden, John F, Hopewell, Jemma C, Kyriakou, Theodosios, Goel, Anuj, Heath, Simon C, Parish, Sarah, Barlera, Simona, Franzosi, Maria Grazia, Rust, Stephan, Bennett, Derrick, Silveira, Angela, Malarstig, Anders, Green, Fiona R, Lathrop, Mark, Gigante, Bruna, Leander, Karin, de Faire, Ulf, Seedorf, Udo, Hamsten, Anders, Collins, Rory, Watkins, Hugh, Farrall, Martin

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Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study von Bourne, Rupert, Flaxman, Seth, Taylor, Hugh R, Casson, Robert James, Abdoli, Amir, Abu-Gharbieh, Eman, Alamneh, Alehegn Aderaw, Alemayehu, Wondu, Alipour, Vahid, Anbesu, Etsay Woldu, Arabloo, Jalal, Arditi, Aries, Bagli, Eleni, Baig, Atif Amin, Bhagavathula, Akshaya Srikanth, Bhattacharyya, Krittika, Bijani, Ali, Bottone, Michele, Butt, Zahid A, Cheng, Ching-Yu, Chu, Dinh-Toi, Dana, Reza, Dandona, Lalit, Dandona, Rakhi, Del Monte, Monte A, Deva, Jenny P, Diaz, Daniel, Djalalinia, Shirin, Dreer, Laura E, Ehrlich, Joshua R, Ellwein, Leon B, Emamian, Mohammad Hassan, Fischer, Florian, Friedman, David S, Furtado, João M, Gaidhane, Shilpa, Gazzard, Gus, George, Ronnie, Golechha, Mahaveer, Hartnett, Mary Elizabeth R, Hartono, Risky Kusuma, Heidari, Golnaz, Ho, Hung Chak, Hoang, Chi Linh, Ilic, Irena M, Ilic, Milena D, Ingram, April D, Irvani, Seyed Sina Naghibi, Kahloun, Rim, Kandel, Himal, Kasa, Ayele Semachew, Kempen, John H, Khairallah, Moncef, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Koyanagi, Ai, Kurmi, Om P, Lansingh, Van Charles, Leveziel, Nicolas, Limburg, Hans, Majdan, Marek, Manafi, Navid, McAlinden, Colm, Mohammadi, Seyed Farzad, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mokdad, Ali H, Moosavi, Delaram, Morse, Alan R, Naidoo, Kovin S, Nangia, Vinay, Nguyen, Cuong Tat, Ogundimu, Kolawole, Ostroff, Samuel M, Pesudovs, Konrad, Peto, Tunde, Quazi Syed, Zahiruddin, Ramulu, Pradeep Y, Rawaf, David Laith, Robin, Alan L, Rossetti, Luca, Safi, Sare, Samy, Abdallah M, Saxena, Deepak, Shen, Tueng T, Shibuya, Kenji, Shin, Jae Il, Silva, Juan Carlos, Singh, Jasvinder A, Skiadaresi, Eirini, Soheili, Amin, Sousa, Raúl A R C, Stambolian, Dwight, Topouzis, Fotis, Travillian, Ravensara S, Varma, Rohit, Wang, Ya Xing, West, Sheila K, Jonas, Jost B

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Active adaptive conservation of threatened species in the face of uncertainty von McDonald-Madden, Eve, Probert, William J. M., Hauser, Cindy E., Runge, Michael C., Possingham, Hugh P., Jones, Menna E., Moore, Joslin L., Rout, Tracy M., Vesk, Peter A., Wintle, Brendan A.

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Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders von Wittenberg, Gayle M., Stylianou, Annie, Zhang, Yun, Sun, Yu, Gupta, Ashutosh, Jagannatha, P. S., Wang, Dai, Hsu, Benjamin, Curran, Mark E., Khan, Shahid, Chen, Guang, Bullmore, Edward T., Drevets, Wayne C.

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Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial von de Bono, Johann S, Concin, Nicole, Hong, David S, Thistlethwaite, Fiona C, Machiels, Jean-Pascal, Arkenau, Hendrik-Tobias, Plummer, Ruth, Jones, Robert Hugh, Nielsen, Dorte, Windfeld, Kristian, Ghatta, Srinivas, Slomovitz, Brian M, Spicer, James F, Yachnin, Jeffrey, Ang, Joo Ern, Mau-Sørensen, Paul Morten, Forster, Martin David, Collins, Dearbhaile, Dean, Emma, Rangwala, Reshma A, Lassen, Ulrik

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Multiple-Locus Variable-Number Tandem Repeat Analysis Reveals Genetic Relationships within Bacillus anthracis von Keim, P, Price, L B, Klevytska, A M, Smith, K L, Schupp, J M, Okinaka, R, Jackson, P J, Hugh-Jones, M E

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Impact of HO2 aerosol uptake on radical levels and O3 production during summertime in Beijing von Dyson, Joanna E, Whalley, Lisa K, Slater, Eloise J, Woodward-Massey, Robert, Ye, Chunxiang, Lee, James D, Squires, Freya, Hopkins, James R, Dunmore, Rachel E, Shaw, Marvin, Hamilton, Jacqueline F, Lewis, Alastair C, Worrall, Stephen D, Asan Bacak, Mehra, Archit, Bannan, Thomas J, Coe, Hugh, Percival, Carl J, Ouyang, Bin, Hewitt, C Nicholas, Jones, Roderic L, Crilley, Leigh R, Kramer, Louisa J, Acton, W Joe F, Bloss, William J, Saksakulkrai, Supattarachai, Xu, Jingsha, Shi, Zongbo, Harrison, Roy M, Kotthaus, Simone, Grimmond, Sue, Sun, Yele, Xu, Weiqi, Siyao Yue, Wei, Lianfang, Fu, Pingqing, Wang, Xinming, Arnold, Stephen R, Heard, Dwayne E

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Revealing the Reactivity of Individual Chemical Entities in Complex Mixtures: the Chemistry Behind Bio-Oil Upgrading von Palacio Lozano, Diana Catalina, Jones, Hugh E., Gavard, Remy, Thomas, Mary J., Ramírez, Claudia X., Wootton, Christopher A., Sarmiento Chaparro, José Aristóbulo, O’Connor, Peter B., Spencer, Simon E. F., Rossell, David, Mejia-Ospino, Enrique, Witt, Matthias, Barrow, Mark P.

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