Vinyl Moiety as a Handle for Regiocontrol in the Preparation of Unsymmetrical 2,3-Aliphatic-Substituted Indoles and Pyrroles von Huestis, Malcolm P, Chan, Lina, Stuart, David R, Fagnou, Keith

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Ni-Catalyzed Reductive Cross-Coupling of Cyclopropylamines and Other Strained Ring NHP Esters with (Hetero)Aryl Halides von West, Michael S., Gabbey, Alexis L., Huestis, Malcolm P., Rousseaux, Sophie A. L.

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Photoredox/Nickel Dual Catalytic Cross-Coupling of Potassium Thiomethyltrifluoroborates with Aryl and Heteroaryl Bromides von Townsend, Katherine, Huestis, Malcolm P, Tellis, John C

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Dual Photoredox/Nickel-Catalyzed Conversion of Aryl Halides to Aryl Aminooxetanes: Computational Evidence for a Substrate-Dependent Switch in Mechanism von Kolahdouzan, Kavoos, Khalaf, Ryan, Grandner, Jessica M, Chen, Yongsheng, Terrett, Jack A, Huestis, Malcolm P

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Cyanide Anion as a Leaving Group in Nucleophilic Aromatic Substitution: Synthesis of Quaternary Centers at Azine Heterocycles von Thompson, Alexander D, Huestis, Malcolm P

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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor von Huestis, Malcolm P, Dela Cruz, Darlene, DiPasquale, Antonio G, Durk, Matthew R, Eigenbrot, Charles, Gibbons, Paul, Gobbi, Alberto, Hunsaker, Thomas L, La, Hank, Leung, Dennis H, Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G, Muli, Christine S, Orr, Christine J, Parr, Brendan T, Shanahan, Frances, Sneeringer, Christopher J, Wang, Weiru, Yen, Ivana, Yin, Jianping, Siu, Michael, Rudolph, Joachim

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Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models von Patel, Snahel, Cohen, Frederick, Dean, Brian J., De La Torre, Kelly, Deshmukh, Gauri, Estrada, Anthony A., Ghosh, Arundhati Sengupta, Gibbons, Paul, Gustafson, Amy, Huestis, Malcolm P., Le Pichon, Claire E., Lin, Han, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Ly, Cuong Q., Lyssikatos, Joseph P., Ma, Changyou, Scearce-Levie, Kimberly, Shin, Young G., Solanoy, Hilda, Stark, Kimberly L., Wang, Jian, Wang, Bei, Zhao, Xianrui, Lewcock, Joseph W., Siu, Michael

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Optimization of a Novel DEL Hit That Binds in the Cbl‑b SH2 Domain and Blocks Substrate Binding von Liang, Jun, Lambrecht, Michael J., Arenzana, Teresita L., Aubert-Nicol, Samuel, Bao, Linda, Broccatelli, Fabio, Cai, Jianping, Eidenschenk, Celine, Everett, Christine, Garner, Thomas, Gruber, Felix, Haghshenas, Pouyan, Huestis, Malcolm P., Hsu, Peter L., Kou, Ponien, Jakalian, Araz, Larouche-Gauthier, Robin, Leclerc, Jean-Philippe, Leung, Dennis H., Martin, Aaron, Murray, Jeremy, Prangley, Madeleine, Rutz, Sascha, Kakiuchi-Kiyota, Satoko, Satz, Alexander Lee, Skelton, Nicholas J., Steffek, Micah, Stoffler, Daniel, Sudhamsu, Jawahar, Tan, Sophia, Wang, Jian, Wang, Shouliang, Wang, Qiuyue, Wendorff, Timothy J., Wichert, Moreno, Yadav, Arun, Yu, Christine, Wang, Xiaojing

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Directed CpRh III -Catalyzed Fluorosulfonylvinylation of Arenes von Ncube, Gqwetha, Huestis, Malcolm P.

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Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors von Volgraf, Matthew, Chan, Lina, Huestis, Malcolm P., Purkey, Hans E., Burkard, Michael, Geck Do, Mary, Harris, Julie, Hunt, Kevin W., Liu, Xingrong, Lyssikatos, Joseph P., Rana, Sumeet, Thomas, Allen A., Vigers, Guy P.A., Siu, Michael

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Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides von Beaton, Stephen A, Huestis, Malcolm P, Sadeghi-Khomami, Ali, Thomas, Neil R, Jakeman, David L

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Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates von Huestis, Malcolm P, Aish, Gaia A, Hui, Joseph P M, Soo, Evelyn C, Jakeman, David L

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Iridium(III)-Catalyzed Benzylic Amine Directed CH Sulfonamidation of Arenes with Sulfonyl Azides von Chen, Heng, Huestis, Malcolm P.

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Engineering Ribonucleoside Triphosphate Specificity in a Thymidylyltransferase von Jakeman, David L, Young, Jessica L, Huestis, Malcolm P, Peltier, Pauline, Daniellou, Richard, Nugier-Chauvin, Caroline, Ferrières, Vincent

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Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 von Xu, Jie, Carrera, Diane E., Beaudry, Danial, Siu, Michael, Huestis, Malcolm P., Liu, Wendy, Angelaud, Rémy, Gosselin, Francis

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Inside Cover: Iridium(III)-Catalyzed Benzylic Amine Directed CH Sulfonamidation of Arenes with Sulfonyl Azides von Chen, Heng, Huestis, Malcolm P

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Iridium(III)-Catalyzed Benzylic Amine Directed CH Sulfonamidation of Arenes with Sulfonyl Azides von Chen, Heng, Huestis, Malcolm P

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Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11and Zirconium‐89 von Lin, Daniel, Lechermann, Laura M, Huestis, Malcolm P, Marik, Jan, Sap, Jeroen B I

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Immune cells avoid death from immunoproteasome inhibitors by switching to conventional proteasome von Ladi, Ena, Everett, Christine, Daniels, Blake, Huestis, Malcolm, Dere, Ed, Gause, Haley, Dirk, Matthew, Rajapaksa, Kathila, Staben, Steve, Purkey, Hans, Eidenschenk, Celine, Siu, Mike, Pappu, Rajita

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AB3 building blocks for the synthesis of polyester dendrimers von Twibanire, Jean-d’Amour K., Huestis, Malcolm P., Grindley, T. Bruce

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