Synthetic single domain antibodies for the conformational trapping of membrane proteins von Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric Aj, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger Jp, Seeger, Markus A

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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers von Sivaramakrishnan, Manaswini, McCarthy, Kathleen D., Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N., Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R., Allain, Frédéric H.-T., Metzger, Friedrich

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DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome von Richter, Hans, Satz, Alexander L, Bedoucha, Marc, Buettelmann, Bernd, Petersen, Ann C, Harmeier, Anja, Hermosilla, Ricardo, Hochstrasser, Remo, Burger, Dominique, Gsell, Bernard, Gasser, Rodolfo, Huber, Sylwia, Hug, Melanie N, Kocer, Buelent, Kuhn, Bernd, Ritter, Martin, Rudolph, Markus G, Weibel, Franziska, Molina-David, Judith, Kim, Jin-Ju, Santos, Javier Varona, Stihle, Martine, Georges, Guy J, Bonfil, R. Daniel, Fridman, Rafael, Uhles, Sabine, Moll, Solange, Faul, Christian, Fornoni, Alessia, Prunotto, Marco

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Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance von Bocquet, Nicolas, Kohler, Josiane, Hug, Melanie N., Kusznir, Eric A., Rufer, Arne C., Dawson, Roger J., Hennig, Michael, Ruf, Armin, Huber, Walter, Huber, Sylwia

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia von Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas

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Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies von Hoffmann, Eugenia, Jordan, Gregor, Lauer, Matthias, Ringler, Philippe, Kusznir, Eric A., Rufer, Arne C., Huber, Sylwia, Jochner, Anton, Winter, Gerhard, Staack, Roland F.

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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands von Huber, Sylwia, Casagrande, Fabio, Hug, Melanie N, Wang, Lisha, Heine, Philipp, Kummer, Lutz, Plückthun, Andreas, Hennig, Michael

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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication von Cabrera, Alvaro Cortes, Melo, Esther, Roth, Doris, Topp, Andreas, Delobel, Frederic, Stucki, Corinne, Chen, Chia-yi, Jakob, Peter, Banfai, Balazs, Dunkley, Tom, Schilling, Oliver, Huber, Sylwia, Iacone, Roberto, Petrone, Paula

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Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans von Dangy, Jean-Pierre, Scherr, Nicole, Gersbach, Philipp, Hug, Melanie N, Bieri, Raphael, Bomio, Claudio, Li, Jun, Huber, Sylwia, Altmann, Karl-Heinz, Pluschke, Gerd

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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies von Moors, Tim E, Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N, Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D J, Britschgi, Markus

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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport von Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina, Gärtner, Achim, Hoffmann, Eike, Niewoehner, Jens, Patsch, Christoph, Baumann, Karlheinz, Loetscher, Hansruedi, Kitas, Eric, Freskgård, Per-Ola

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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling von Moisan, Annie, Gubler, Marcel, Zhang, Jitao David, Tessier, Yann, Dumong Erichsen, Kamille, Sewing, Sabine, Gérard, Régine, Avignon, Blandine, Huber, Sylwia, Benmansour, Fethallah, Chen, Xing, Villaseñor, Roberto, Braendli-Baiocco, Annamaria, Festag, Matthias, Maunz, Andreas, Singer, Thomas, Schuler, Franz, Roth, Adrian B.

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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy von Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Spycher, Liz, Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J. G., Gerwert, Klaus, Britschgi, Markus, van de Berg, Wilma D. J.

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Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization von Benz, Joerg, Rufer, Arne C., Huber, Sylwia, Ehler, Andreas, Hug, Melanie, Topp, Andreas, Guba, Wolfgang, Hofmann, Eva Carolina, Jagasia, Ravi, Rodríguez Sarmiento, Rosa María

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Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 von Dawson, Roger J.P., Benz, Jörg, Stohler, Peter, Tetaz, Tim, Joseph, Catherine, Huber, Sylwia, Schmid, Georg, Hügin, Daniela, Pflimlin, Pascal, Trube, Gerd, Rudolph, Markus G., Hennig, Michael, Ruf, Armin

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Propensities of Fatty Acid-Modified ASOs: Self-Assembly vs Albumin Binding von Kusznir, Eric-André, Hau, Jean-Christophe, Portmann, Michaela, Reinhart, Anne-Gaëlle, Falivene, Fabio, Bastien, Jessica, Worm, Jesper, Ross, Alfred, Lauer, Matthias, Ringler, Philippe, Sladojevich, Filippo, Huber, Sylwia, Bleicher, Konrad, Keller, Michael

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Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain von Richter, Kirsten, Rufer, Arne C., Muller, Magali, Burger, Dominique, Casagrande, Fabio, Grossenbacher, Tabea, Huber, Sylwia, Hug, Melanie N., Koldewey, Philipp, D'Osualdo, Andrea, Schlatter, Daniel, Stoll, Theodor, Rudolph, Markus G.

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Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP von Ebenhoch, Rebecca, Bauer, Margit, Reinert, Dirk, Kersting, Anja, Huber, Sylwia, Schmid, Angela, Hinz, Ingo, Feiler, Marisa, Müller, Kathrin, Nar, Herbert

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Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells von Sarott, Roman C, Westphal, Matthias V, Pfaff, Patrick, Korn, Claudia, Sykes, David A, Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Weise, Marie, Mostinski, Yelena, Hompluem, Pattarin, Koers, Eline, Miljuš, Tamara, Roth, Nicolas J, Asmelash, Hermon, Vong, Man C, Piovesan, Jacopo, Guba, Wolfgang, Rufer, Arne C, Kusznir, Eric A, Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A, Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Benito-Cuesta, Irene, Grande, Teresa, Ruiz de Martı́n Esteban, Samuel, Yeliseev, Alexei, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Yuan, Cheng-Yin, Drobyski, William R, Saroz, Yurii, Grimsey, Natasha, Honer, Michael, Fingerle, Jürgen, Gawrisch, Klaus, Romero, Julian, Hillard, Cecilia J, Varga, Zoltan V, van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, McCormick, Peter J, Ullmer, Christoph, Oddi, Sergio, Maccarrone, Mauro, Veprintsev, Dmitry B, Nazaré, Marc, Grether, Uwe, Carreira, Erick M

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Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors von Kuhn, Bernd, Ritter, Martin, Hornsperger, Benoit, Bell, Charles, Kocer, Buelent, Rombach, Didier, Lutz, Marius D. R., Gobbi, Luca, Kuratli, Martin, Bartelmus, Christian, Bürkler, Markus, Koller, Raffael, Tosatti, Paolo, Ruf, Iris, Guerard, Melanie, Pavlovic, Anto, Stephanus, Juliane, O’Hara, Fionn, Wetzl, Dennis, Saal, Wiebke, Stihle, Martine, Roth, Doris, Hug, Melanie, Huber, Sylwia, Heer, Dominik, Kroll, Carsten, Topp, Andreas, Schneider, Manfred, Gertsch, Jürg, Glasmacher, Sandra, van der Stelt, Mario, Martella, Andrea, Wittwer, Matthias Beat, Collin, Ludovic, Benz, Jörg, Richter, Hans, Grether, Uwe

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