Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas von Amoozgar, Zohreh, Kloepper, Jonas, Ren, Jun, Tay, Rong En, Kazer, Samuel W., Kiner, Evgeny, Krishnan, Shanmugarajan, Posada, Jessica M., Ghosh, Mitrajit, Mamessier, Emilie, Wong, Christina, Ferraro, Gino B., Batista, Ana, Wang, Nancy, Badeaux, Mark, Roberge, Sylvie, Xu, Lei, Huang, Peigen, Shalek, Alex K., Fukumura, Dai, Kim, Hye-Jung, Jain, Rakesh K.

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Dual Programmed Death Receptor‐1 and Vascular Endothelial Growth Factor Receptor‐2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellula... von Shigeta, Kohei, Datta, Meenal, Hato, Tai, Kitahara, Shuji, Chen, Ivy X., Matsui, Aya, Kikuchi, Hiroto, Mamessier, Emilie, Aoki, Shuichi, Ramjiawan, Rakesh R., Ochiai, Hiroki, Bardeesy, Nabeel, Huang, Peigen, Cobbold, Mark, Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.

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Gut microbiota is critical for the induction of chemotherapy-induced pain von Shen, Shiqian, Lim, Grewo, You, Zerong, Ding, Weihua, Huang, Peigen, Ran, Chongzhao, Doheny, Jason, Caravan, Peter, Tate, Samuel, Hu, Kun, Kim, Hyangin, McCabe, Michael, Huang, Bo, Xie, Zhongcong, Kwon, Douglas, Chen, Lucy, Mao, Jianren

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CXCR4 inhibition in tumor microenvironment facilitates anti‐programmed death receptor‐1 immunotherapy in sorafenib‐treated hepatocellular carcinoma in mice von Chen, Yunching, Ramjiawan, Rakesh R., Reiberger, Thomas, Ng, Mei R., Hato, Tai, Huang, Yuhui, Ochiai, Hiroki, Kitahara, Shuji, Unan, Elizabeth C., Reddy, Tejaswini P., Fan, Christopher, Huang, Peigen, Bardeesy, Nabeel, Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.

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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy von Huang, Yuhui, Yuan, Jianping, Righi, Elda, Kamoun, Walid S., Ancukiewicz, Marek, Nezivar, Jean, Santosuosso, Michael, Martin, John D., Martin, Margaret R., Vianello, Fabrizio, Leblanc, Pierre, Munn, Lance L., Huang, Peigen, Duda, Dan G., Fukumura, Dai, Jain, Rakesh K., Poznansky, Mark C.

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Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy von Incio, Joao, Liu, Hao, Suboj, Priya, Chin, Shan M, Chen, Ivy X, Pinter, Matthias, Ng, Mei R, Nia, Hadi T, Grahovac, Jelena, Kao, Shannon, Babykutty, Suboj, Huang, Yuhui, Jung, Keehoon, Rahbari, Nuh N, Han, Xiaoxing, Chauhan, Vikash P, Martin, John D, Kahn, Julia, Huang, Peigen, Desphande, Vikram, Michaelson, James, Michelakos, Theodoros P, Ferrone, Cristina R, Soares, Raquel, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

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Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal‐derived factor 1 alpha/C‐X‐C receptor type 4 axis and myeloid differentiation antigen–positive... von Chen, Yunching, Huang, Yuhui, Reiberger, Thomas, Duyverman, Annique M., Huang, Peigen, Samuel, Rekha, Hiddingh, Lotte, Roberge, Sylvie, Koppel, Christina, Lauwers, Gregory Y., Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.

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In vivo compression and imaging in mouse brain to measure the effects of solid stress von Nia, Hadi T., Datta, Meenal, Seano, Giorgio, Zhang, Sue, Ho, William W., Roberge, Sylvie, Huang, Peigen, Munn, Lance L., Jain, Rakesh K.

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An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis von Reiberger, Thomas, Chen, Yunching, Ramjiawan, Rakesh R, Hato, Tai, Fan, Christopher, Samuel, Rekha, Roberge, Sylvie, Huang, Peigen, Lauwers, Gregory Y, Zhu, Andrew X, Bardeesy, Nabeel, Jain, Rakesh K, Duda, Dan G

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Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma von Shigeta, Kohei, Matsui, Aya, Kikuchi, Hiroto, Klein, Sebastian, Mamessier, Emilie, Chen, Ivy X, Aoki, Shuichi, Kitahara, Shuji, Inoue, Koetsu, Shigeta, Ayako, Hato, Tai, Ramjiawan, Rakesh R, Staiculescu, Daniel, Zopf, Dieter, Fiebig, Lukas, Hobbs, Gabriela S, Quaas, Alexander, Dima, Simona, Popescu, Irinel, Huang, Peigen, Munn, Lance L, Cobbold, Mark, Goyal, Lipika, Zhu, Andrew X, Jain, Rakesh K, Duda, Dan G

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Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment von Wang, Yufeng, Drum, David L., Sun, Ruochuan, Zhang, Yida, Chen, Feng, Sun, Fengfei, Dal, Emre, Yu, Ling, Jia, Jingyu, Arya, Shahrzad, Jia, Lin, Fan, Song, Isakoff, Steven J., Kehlmann, Allison M., Dotti, Gianpietro, Liu, Fubao, Zheng, Hui, Ferrone, Cristina R., Taghian, Alphonse G., DeLeo, Albert B., Ventin, Marco, Cattaneo, Giulia, Li, Yongxiang, Jounaidi, Youssef, Huang, Peigen, Maccalli, Cristina, Zhang, Hanyu, Wang, Cheng, Yang, Jibing, Boland, Genevieve M., Sadreyev, Ruslan I., Wong, LaiPing, Ferrone, Soldano, Wang, Xinhui

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Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model von Gao, Xing, Zhao, Yingchao, Stemmer-Rachamimov, Anat O., Liu, Hao, Huang, Peigen, Chin, ShanMin, Selig, Martin K., Plotkin, Scott R., Jain, Rakesh K., Xu, Lei

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Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium von Seano, Giorgio, Nia, Hadi T., Emblem, Kyrre E., Datta, Meenal, Ren, Jun, Krishnan, Shanmugarajan, Kloepper, Jonas, Pinho, Marco C., Ho, William W., Ghosh, Mitrajit, Askoxylakis, Vasileios, Ferraro, Gino B., Riedemann, Lars, Gerstner, Elizabeth R., Batchelor, Tracy T., Wen, Patrick Y., Lin, Nancy U., Grodzinsky, Alan J., Fukumura, Dai, Huang, Peigen, Baish, James W., Padera, Timothy P., Munn, Lance L., Jain, Rakesh K.

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PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer von JIEQIONG LIU, SHAN LIAO, LEI XU, YUHUI HUANG, SAMUEL, Rekha, SHI, Tony, NAXEROVA, Kamila, PEIGEN HUANG, KAMOUN, Walid, JAIN, Rakesh K, FUKUMURA, Dai

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Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast... von Guo, Wei, Jia, Lin, Xie, Ling, Kiang, Juliann G., Wang, Yangyang, Sun, Fengfei, Lin, Zunwen, Wang, Enwen, Zhang, Yida, Huang, Peigen, Sun, Ting, Zhang, Xiao, Bian, Zhengying, Tang, Tiejun, Guo, Jingtian, Ferrone, Soldano, Wang, Xinhui

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Solid stress impairs lymphocyte infiltration into lymph-node metastases von Jones, Dennis, Wang, Zixiong, Chen, Ivy X., Zhang, Sue, Banerji, Rohin, Lei, Pin-Ji, Zhou, Hengbo, Xiao, Victoria, Kwong, Cecilia, van Wijnbergen, Jan Willem M., Pereira, Ethel R., Vakoc, Benjamin J., Huang, Peigen, Nia, Hadi T., Padera, Timothy P.

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Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors von Chen, Yunching, Liu, Ya-Chi, Sung, Yun-Chieh, Ramjiawan, Rakesh R., Lin, Ts-Ting, Chang, Chih-Chun, Jeng, Kuo-Shyang, Chang, Chiung-Fang, Liu, Chun-Hung, Gao, Dong-Yu, Hsu, Fu-Fei, Duyverman, Annique M., Kitahara, Shuji, Huang, Peigen, Dima, Simona, Popescu, Irinel, Flaherty, Keith T., Zhu, Andrew X., Bardeesy, Nabeel, Jain, Rakesh K., Benes, Cyril H., Duda, Dan G.

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Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model von Li, Wende, Li, Sen, Chen, Ivy X, Liu, Yujiao, Ramjiawan, Rakesh R, Leung, Chi-Ho, Gerweck, Leo E, Fukumura, Dai, Loeffler, Jay S, Jain, Rakesh K, Duda, Dan G, Huang, Peigen

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Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models von Gupta, Nisha, Ochiai, Hiroki, Hoshino, Yoshinori, Klein, Sebastian, Zustin, Jozef, Ramjiawan, Rakesh R, Kitahara, Shuji, Maimon, Nir, Bazou, Despina, Chiang, Sarah, Li, Sen, Schanne, Daniel H, Jain, Rakesh K, Munn, Lance L, Huang, Peigen, Kozin, Sergey V, Duda, Dan G

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Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutrons von Gerweck, Leo E., PhD, Huang, Peigen, MD, Lu, Hsiao-Ming, PhD, Paganetti, Harald, PhD, Zhou, Yenong, BS

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