Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics von Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C S, Strasser, Andreas

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival von Schwickart, Martin, Dornan, David, Huang, David C. S, Liu, Jinfeng, Lill, Jennie R, Maecker, Heather, Bazan, Fernando, Huang, XiaoDong, Yue, Peng, French, Dorothy M, Eastham-Anderson, Jeffrey, Dixit, Vishva M, Ferrando, Ronald, O'Rourke, Karen

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Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease von ROBERTS, Andrew W, SEYMOUR, John F, YUE CUI, BUSMAN, Todd A, MCKEEGAN, Evelyn M, KRIVOSHIK, Andrew P, ENSCHEDE, Sari H, HUMERICKHOUSE, Rod, BROWN, Jennifer R, WIERDA, William G, KIPPS, Thomas J, SEONG LIN KHAW, CARNEY, Dennis A, HE, Simon Z, HUANG, David C. S, HAO XIONG

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XIAP discriminates between type I and type II FAS-induced apoptosis von Strasser, Andreas, Kaufmann, Thomas, Jost, Philipp J, Grabow, Stephanie, Gray, Daniel, McKenzie, Mark D, Nachbur, Ueli, Huang, David C. S, Bouillet, Philippe, Thomas, Helen E, Borner, Christoph, Silke, John

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BCL2 and MCL1 inhibitors for hematologic malignancies von Roberts, Andrew W., Wei, Andrew H., Huang, David C.S.

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production von White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

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Mesenchymal stromal cell apoptosis is required for their therapeutic function von Pang, Swee Heng Milon, D’Rozario, Joshua, Mendonca, Senora, Bhuvan, Tejasvini, Payne, Natalie L., Zheng, Di, Hisana, Assifa, Wallis, Georgia, Barugahare, Adele, Powell, David, Rautela, Jai, Huntington, Nicholas D., Dewson, Grant, Huang, David C. S., Gray, Daniel H. D., Heng, Tracy S. P.

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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak von Willis, Simon N, Fletcher, Jamie I, Kaufmann, Thomas, van Delft, Mark F, Chen, Lin, Czabotar, Peter E, Ierino, Helen, Lee, Erinna F, Fairlie, W. Douglas, Bouillet, Philippe, Strasser, Andreas, Kluck, Ruth M, Adams, Jerry M, Huang, David C.S

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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations von Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.

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Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis von Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth M., Adams, Jerry M., Colman, Peter M.

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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak von Lindqvist, Lisa M., Heinlein, Melanie, Huang, David C. S., Vaux, David L.

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MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex von Djajawi, Tirta Mario, Liu, Lei, Gong, Jia-nan, Huang, Allan Shuai, Luo, Ming-jie, Xu, Zhen, Okamoto, Toru, Call, Melissa J., Huang, David C. S., van Delft, Mark F.

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Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 von Oakes, Samantha R, Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E, Takano, Elena, Ward, Teresa, Fox, Stephen B, Generali, Daniele, Smyth, Gordon K, Strasser, Andreas, Huang, David C. S, Visvader, Jane E, Lindeman, Geoffrey J

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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis von Yuan, Zheng, van Delft, Mark F, Li, Mark Xiang, Sumardy, Fransisca, Smith, Brian J, Huang, David C S, Lessene, Guillaume, Khakam, Yelena, Jin, Ruitao, He, Sitong, Smith, Nicholas A, Birkinshaw, Richard W, Czabotar, Peter E, Dewson, Grant

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A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii von Yamamoto, Masahiro, Okuyama, Megumi, Ma, Ji Su, Kimura, Taishi, Kamiyama, Naganori, Saiga, Hiroyuki, Ohshima, Jun, Sasai, Miwa, Kayama, Hisako, Okamoto, Toru, Huang, David C.S., Soldati-Favre, Dominique, Horie, Kyoji, Takeda, Junji, Takeda, Kiyoshi

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The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism von Anderson, Mary Ann, Deng, Jing, Seymour, John F., Tam, Constantine, Kim, Su Young, Fein, Joshua, Yu, Lijian, Brown, Jennifer R., Westerman, David, Si, Eric G., Majewski, Ian J., Segal, David, Heitner Enschede, Sari L., Huang, David C.S., Davids, Matthew S., Letai, Anthony, Roberts, Andrew W.

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Association between adolescent substance use and obesity in young adulthood: A group-based dual trajectory analysis von Huang, David Y.C, Lanza, H. Isabella, Anglin, M. Douglas

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Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia von Blombery, Piers, Anderson, Mary Ann, Gong, Jia-Nan, Thijssen, Rachel, Birkinshaw, Richard W, Thompson, Ella R, Teh, Charis E, Nguyen, Tamia, Xu, Zhen, Flensburg, Christoffer, Lew, Thomas E, Majewski, Ian J, Gray, Daniel H D, Westerman, David A, Tam, Constantine S, Seymour, John F, Czabotar, Peter E, Huang, David C S, Roberts, Andrew W

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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling von Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J., Herold, Marco J., Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C. S., Liu, Ming, Ju, Junyi, Zhao, Quan

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Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis von Seymour, Christopher W, Kennedy, Jason N, Wang, Shu, Chang, Chung-Chou H, Elliott, Corrine F, Xu, Zhongying, Berry, Scott, Clermont, Gilles, Cooper, Gregory, Gomez, Hernando, Huang, David T, Kellum, John A, Mi, Qi, Opal, Steven M, Talisa, Victor, van der Poll, Tom, Visweswaran, Shyam, Vodovotz, Yoram, Weiss, Jeremy C, Yealy, Donald M, Yende, Sachin, Angus, Derek C

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