Cryo-EM structure determination captures new chemical modification of protein von Jiang, Hualiang

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Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease von Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun

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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir von Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric

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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin von Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H.

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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease von Dai, Wenhao, Zhang, Bing, Jiang, Xia-Ming, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong

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Rhodium(III)-Catalyzed Site-Selective C–H Alkylation and Arylation of Pyridones Using Organoboron Reagents von Peng, Panfeng, Wang, Jiang, Jiang, Hualiang, Liu, Hong

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Full-length human GLP-1 receptor structure without orthosteric ligands von Wu, Fan, Yang, Linlin, Hang, Kaini, Laursen, Mette, Wu, Lijie, Han, Gye Won, Ren, Qiansheng, Roed, Nikolaj Kulahin, Lin, Guangyao, Hanson, Michael A., Jiang, Hualiang, Wang, Ming-Wei, Reedtz-Runge, Steffen, Song, Gaojie, Stevens, Raymond C.

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Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target von Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W., Yang, Haitao, Rao, Zihe

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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase von Xu, Yechun, Jiang, Hualiang

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Structural basis of leukotriene B4 receptor 1 activation von Wang, Na, He, Xinheng, Zhao, Jing, Jiang, Hualiang, Cheng, Xi, Xia, Yu, Eric Xu, H., He, Yuanzheng

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Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia von Huang, Yue, Su, Rui, Sheng, Yue, Dong, Lei, Dong, Ze, Xu, Hongjiao, Ni, Tengfeng, Zhang, Zijie Scott, Zhang, Tao, Li, Chenying, Han, Li, Zhu, Zhenyun, Lian, Fulin, Wei, Jiangbo, Deng, Qiangqiang, Wang, Yungui, Wunderlich, Mark, Gao, Zhiwei, Pan, Guoyu, Zhong, Dafang, Zhou, Hu, Zhang, Naixia, Gan, Jianhua, Jiang, Hualiang, Mulloy, James C., Qian, Zhijian, Chen, Jianjun, Yang, Cai-Guang

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Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol von Cao, Duanfang, Wang, Mingzhu, Qiu, Xiayang, Liu, Dongxiang, Jiang, Hualiang, Yang, Na, Xu, Rui-Ming

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SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 1. Method and Assessment of Virtual Screening von Liu, Xiaofeng, Jiang, Hualiang, Li, Honglin

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Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 von Yu, Bo, Li, Chenze, Chen, Peng, Zhou, Ning, Wang, Luyun, Li, Jia, Jiang, Hualiang, Wang, Dao-Wen

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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2 von Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan

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Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors von Duan, Jia, Shen, Dan-Dan, Zhao, Tingting, Guo, Shimeng, He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, Li-Nan, Liu, Jinyu, Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Eric Xu, H., Zhang, Yan, Xie, Xin, Jiang, Yi

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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir von Jiang, Xiangrui, Su, Haixia, Shang, Weijuan, Zhou, Feng, Zhang, Yan, Zhao, Wenfeng, Zhang, Qiumeng, Xie, Hang, Jiang, Lei, Nie, Tianqing, Yang, Feipu, Xiong, Muya, Huang, Xiaoxing, Li, Minjun, Chen, Ping, Peng, Shaoping, Xiao, Gengfu, Jiang, Hualiang, Tang, Renhong, Zhang, Leike, Shen, Jingshan, Xu, Yechun

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Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus von Ji, Quanjiang, Chen, Peter J., Qin, Guangrong, Deng, Xin, Hao, Ziyang, Wawrzak, Zdzislaw, Yeo, Won-Sik, Quang, Jenny Winjing, Cho, Hoonsik, Luo, Guan-Zheng, Weng, Xiaocheng, You, Qiancheng, Luan, Chi-Hao, Yang, Xiaojing, Bae, Taeok, Yu, Kunqian, Jiang, Hualiang, He, Chuan

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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV‑2 von Dai, Wenhao, Jochmans, Dirk, Xie, Hang, Yang, Hang, Li, Jian, Su, Haixia, Chang, Di, Wang, Jiang, Peng, Jingjing, Zhu, Lili, Nian, Yong, Hilgenfeld, Rolf, Jiang, Hualiang, Chen, Kaixian, Zhang, Leike, Xu, Yechun, Neyts, Johan, Liu, Hong

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Two disparate ligand-binding sites in the human P2Y1 receptor von Zhang, Dandan, Gao, Zhan-Guo, Zhang, Kaihua, Kiselev, Evgeny, Crane, Steven, Wang, Jiang, Paoletta, Silvia, Yi, Cuiying, Ma, Limin, Zhang, Wenru, Han, Gye Won, Liu, Hong, Cherezov, Vadim, Katritch, Vsevolod, Jiang, Hualiang, Stevens, Raymond C., Jacobson, Kenneth A., Zhao, Qiang, Wu, Beili

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