Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors von Ni, Yike, Gopalsamy, Ariamala, Cole, Derek, Hu, Yonghan, Denny, Rajiah, Ipek, Manus, Liu, Julie, Lee, Julie, Hall, J. Perry, Luong, Michael, Telliez, Jean-Baptiste, Lin, Lih-Ling

Volltext

Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood von Hall, J. Perry, Kurdi, Yahya, Hsu, Sang, Cuozzo, John, Liu, Julie, Telliez, Jean-Baptiste, Seidl, Katherine J., Winkler, Aaron, Hu, Yonghan, Green, Neal, Askew, G. Roger, Tam, Steve, Clark, James D., Lin, Lih-Ling

Volltext

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood von Wu, Junjun, Green, Neal, Hotchandani, Rajeev, Hu, Yonghan, Condon, Jeffrey, Huang, Adrian, Kaila, Neelu, Li, Huan-Qiu, Guler, Satenig, Li, Wei, Tam, Steve Y., Wang, Qin, Pelker, Jeffrey, Marusic, Suzana, Hsu, Sang, Perry Hall, J., Telliez, Jean-Baptiste, Cui, Junqing, Lin, Lih-Ling

Volltext

Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis von Hu, Yonghan, Green, Neal, Gavrin, Lori K., Janz, Kristin, Kaila, Neelu, Li, Huan-Qiu, Thomason, Jennifer R., Cuozzo, John W., Hall, J. Perry, Hsu, Sang, Nickerson-Nutter, Cheryl, Telliez, Jean-Baptiste, Lin, Lih-Ling, Tam, Steve

Volltext

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis von Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

Volltext

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition von Hu, Yonghan, Xing, Li, Thomason, Jennifer R., Xiang, Jason, Ipek, Manus, Guler, Satenig, Li, Huanqiu, Sabatini, Joshua, Chockalingam, Priya, Reifenberg, Erica, Sheldon, Richard, Morris, Elisabeth A., Georgiadis, Katy E., Tam, Steve

Volltext

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles von Kaila, Neelu, Green, Neal, Li, Huan-Qiu, Hu, Yonghan, Janz, Kristin, Gavrin, Lori Krim, Thomason, Jennifer, Tam, Steve, Powell, Dennis, Cuozzo, John, Hall, J. Perry, Telliez, Jean-Baptiste, Hsu, Sang, Nickerson-Nutter, Cheryl, Wang, Qin, Lin, Lih-Ling

Volltext

Synthesis and SAR of highly selective MMP-13 inhibitors von Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

Volltext

Abstract 1821: Discovery of XNW21015, a novel, potent HPK1 inhibitor with excellent immune modulatory activity von Wu, Yuchuan, Hao, Rui, Chen, Xi, Liu, Xiao, Xie, Yonghua, Wang, Shihua, Gao, Bingquan, Wen, Jichun, Wu, Zhenwei, Wang, Wengui, Wei, Haiyang, Hu, Yonghan, Liu, Xiaojun, Le, Meijie, Qiang, Jing

Volltext

Abstract 3089: XNW5004: a novel EZH2 inhibitor efficacious in multiple cancer xenograft models as a single agent and in combination studies von Hu, Yonghan, Peng, Wei, Zhang, Zhe, Wu, Zhenwei, Chen, Xi, Huang, Yan, Li, Xin, Liu, Cungang, Liu, Xiaojun, Shi, Qifeng, Wang, Xufang, Wang, Wengui, Wei, Haiyang, Wu, Yuchuan, Xian, Jun, Xu, Linfeng, Zhang, Lina, Zhao, Jinfeng, Le, Meijie, Qiang, Jing

Volltext

The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis von Shi, Changchun, Peng, Meng, Du, Yingying, Li, Wenxing, Hu, Yonghan, Wu, Tingting

Volltext

Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylme... von McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D

Volltext

Discovery of indazoles as inhibitors of Tpl2 kinase von Hu, Yonghan, Cole, Derek, Denny, Rajiah Aldrin, Anderson, David R., Ipek, Manus, Ni, Yike, Wang, Xiaolun, Thaisrivongs, Suvit, Chamberlain, Timothy, Hall, J. Perry, Liu, Julie, Luong, Michael, Lin, Lih-Ling, Telliez, Jean-Baptiste, Gopalsamy, Ariamala

Volltext

Discovery of indazoles as inhibitors of Tp12 kinase von YONGHAN HU, COLE, Derek, LIU, Julie, LUONG, Michael, LIN, Lih-Ling, TELLIEZ, Jean-Baptiste, GOPALSAMY, Ariamala, ALDRIN DENNY, Rajiah, ANDERSON, David R, IPEK, Manus, NI, Yike, XIAOLUN WANG, THAISRIVONGS, Suvit, CHAMBERLAIN, Timothy, PERRY HALL, J

Volltext

Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tp12 kinase inhibitors von NI, Yike, GOPALSAMY, Ariamala, TELLIEZ, Jean-Baptiste, LIN, Lih-Ling, COLE, Derek, YONGHAN HU, DENNY, Rajiah, IPEK, Manus, JULIE LIU, LEE, Julie, PERRY HALL, J, LUONG, Michael

Volltext

Peptide compound, application thereof and composition containing same von Wang, Yan, Wu, Yun, Li, Manhua, Hu, Yonghan, Angell, Yvonne

Volltext bestellen

Peptide compound and application thereof, and composition containing peptide compound von Wu, Yu, Liu, Weimin, Wang, Yan, Wen, Jie, Hu, Yonghan, Angell, Yvonne, Fong, Kin Chiu

Volltext bestellen

Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylm... von MCKEW, John C, LEE, Katherine L, CHEN, Lihren, KIRINCICH, Steven J, MICHALAK, Ronald, THOMASON, Jennifer, IPEK, Manus, KUN WU, WOODER, Lane, RAMARAO, Manjunath K, MURPHY, Elizabeth A, GOODWIN, Debra G, SHEN, Marina W. H, ALBERT, Leo, XIN XU, DONAHUE, Frances, SHERRY KU, M, KEITH, James, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, HEGEN, Martin, CLARK, James D, THAKKER, Paresh, FOLEY, Megan A, BEHNKE, Mark L, BAIHUA HU, SUM, Fuk-Wah, TAM, Steve, YONGHAN HU

Volltext

Triply bridged (O,O′,S)-binuclear oxomolybdenum(V) complexes containing o-mercaptophenol ligands von Kang, Beisheng, Hu, Yonghan, Weng, Linghong, Wu, Daxu, Chen, Xuetai, Xu, Yongjin, Lu, Jiaxi

Volltext

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor a (TNF-α) production : Selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-ani... von GREEN, Neal, YONGHAN HU, JUNJUN WU, HUANG, Adrian, QIN WANG, LEUNG, Louis, PELKER, Jefferey, MARUSIC, Suzana, HSU, Sang, TELLIEZ, Jean-Baptiste, HALL, J. Perry, CUOZZO, John W, JANZ, Kristin, LIN, Lih-Ling, LI, Huan-Qiu, KAILA, Neelu, GULER, Satenig, THOMASON, Jennifer, JOSEPH-MCCARTHY, Diane, TAM, Steve Y, HOTCHANDANI, Rajeev

Volltext