Development and applications of CRISPR-Cas9 for genome engineering von Hsu, Patrick D, Lander, Eric S, Zhang, Feng

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Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity von Tycko, Josh, Myer, Vic E., Hsu, Patrick D.

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Structure and Engineering of Francisella novicida Cas9 von Hirano, Hisato, Gootenberg, Jonathan S., Horii, Takuro, Abudayyeh, Omar O., Kimura, Mika, Hsu, Patrick D., Nakane, Takanori, Ishitani, Ryuichiro, Hatada, Izuho, Zhang, Feng, Nishimasu, Hiroshi, Nureki, Osamu

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Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors von Konermann, Silvana, Lotfy, Peter, Brideau, Nicholas J., Oki, Jennifer, Shokhirev, Maxim N., Hsu, Patrick D.

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA von Nishimasu, Hiroshi, Ran, F. Ann, Hsu, Patrick D., Konermann, Silvana, Shehata, Soraya I., Dohmae, Naoshi, Ishitani, Ryuichiro, Zhang, Feng, Nureki, Osamu

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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d von Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

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DNA targeting specificity of RNA-guided Cas9 nucleases von Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A, Bao, Gang, Zhang, Feng

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Multiplex Genome Engineering Using CRISPR/Cas Systems von Cong, Le, Ran, F. Ann, Cox, David, Lin, Shuailiang, Barretto, Robert, Habib, Naomi, Hsu, Patrick D., Wu, Xuebing, Jiang, Wenyan, Marraffini, Luciano A., Zhang, Feng

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Optical control of mammalian endogenous transcription and epigenetic states von Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Hsu, Patrick D., Heidenreich, Matthias, Le Cong, Platt, Randall J., Scott, David A., Church, George M., Zhang, Feng

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex von Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Abudayyeh, Omar O., Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu, Zhang, Feng

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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells von Wu, Xuebing, Scott, David A, Kriz, Andrea J, Chiu, Anthony C, Hsu, Patrick D, Dadon, Daniel B, Cheng, Albert W, Trevino, Alexandro E, Konermann, Silvana, Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Sharp, Phillip A

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Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome von Durrant, Matthew G., Fanton, Alison, Tycko, Josh, Hinks, Michaela, Chandrasekaran, Sita S., Perry, Nicholas T., Schaepe, Julia, Du, Peter P., Lotfy, Peter, Bassik, Michael C., Bintu, Lacramioara, Bhatt, Ami S., Hsu, Patrick D.

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Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy von Gori, Jennifer L, Hsu, Patrick D, Maeder, Morgan L, Shen, Shen, Welstead, G Grant, Bumcrot, David

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Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity von Ran, F. Ann, Hsu, Patrick D., Lin, Chie-Yu, Gootenberg, Jonathan S., Konermann, Silvana, Trevino, Alexandro E., Scott, David A., Inoue, Azusa, Matoba, Shogo, Zhang, Yi, Zhang, Feng

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DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner von Strine, Madison S, Cai, Wesley L, Wei, Jin, Alfajaro, Mia Madel, Filler, Renata B, Biering, Scott B, Sarnik, Sylvia, Chow, Ryan D, Patil, Ajinkya, Cervantes, Kasey S, Collings, Clayton K, DeWeirdt, Peter C, Hanna, Ruth E, Schofield, Kevin, Hulme, Christopher, Konermann, Silvana, Doench, John G, Hsu, Patrick D, Kadoch, Cigall, Yan, Qin, Wilen, Craig B

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The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression von Wei, Jin, Alfajaro, Mia Madel, Cai, Wesley L, Graziano, Vincent R, Strine, Madison S, Filler, Renata B, Biering, Scott B, Sarnik, Sylvia A, Patel, Sonam, Menasche, Bridget L, Compton, Susan R, Konermann, Silvana, Hsu, Patrick D, Orchard, Robert C, Yan, Qin, Wilen, Craig B

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Accelerated RNA detection using tandem CRISPR nucleases von Liu, Tina Y., Knott, Gavin J., Smock, Dylan C. J., Desmarais, John J., Son, Sungmin, Bhuiya, Abdul, Jakhanwal, Shrutee, Prywes, Noam, Agrawal, Shreeya, Díaz de León Derby, María, Switz, Neil A., Armstrong, Maxim, Harris, Andrew R., Charles, Emeric J., Thornton, Brittney W., Fozouni, Parinaz, Shu, Jeffrey, Stephens, Stephanie I., Kumar, G. Renuka, Zhao, Chunyu, Mok, Amanda, Iavarone, Anthony T., Escajeda, Arturo M., McIntosh, Roger, Kim, Shineui, Dugan, Eli J., Pollard, Katherine S., Tan, Ming X., Ott, Melanie, Fletcher, Daniel A., Lareau, Liana F., Hsu, Patrick D., Savage, David F., Doudna, Jennifer A.

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Bridge RNAs direct programmable recombination of target and donor DNA von Durrant, Matthew G., Perry, Nicholas T., Pai, James J., Jangid, Aditya R., Athukoralage, Januka S., Hiraizumi, Masahiro, McSpedon, John P., Pawluk, April, Nishimasu, Hiroshi, Konermann, Silvana, Hsu, Patrick D.

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Structural mechanism of bridge RNA-guided recombination von Hiraizumi, Masahiro, Perry, Nicholas T., Durrant, Matthew G., Soma, Teppei, Nagahata, Naoto, Okazaki, Sae, Athukoralage, Januka S., Isayama, Yukari, Pai, James J., Pawluk, April, Konermann, Silvana, Yamashita, Keitaro, Hsu, Patrick D., Nishimasu, Hiroshi

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Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade von Dmello, Crismita, Zhao, Junfei, Chen, Li, Gould, Andrew, Castro, Brandyn, Arrieta, Victor A., Zhang, Daniel Y., Kim, Kwang-Soo, Kanojia, Deepak, Zhang, Peng, Miska, Jason, Yeeravalli, Ragini, Habashy, Karl, Saganty, Ruth, Kang, Seong Jae, Fares, Jawad, Liu, Connor, Dunn, Gavin, Bartom, Elizabeth, Schipma, Matthew J., Hsu, Patrick D., Alghamri, Mahmoud S., Lesniak, Maciej S., Heimberger, Amy B., Rabadan, Raul, Lee-Chang, Catalina, Sonabend, Adam M.

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