Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation von Östling, Jörgen, Ax, Elisabeth, Calvén, Jenny, Thörn, Kristofer, Israelsson, Elisabeth, Öberg, Lisa, Wilson, Susan J., Ward, Jonathan A., Chauhan, Anoop, Sousa, Ana R., De Meulder, Bertrand, Baribaud, Frédéric, Sterk, Peter J., Guo, Yike, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens M., Sandström, Thomas, James, Anna, Hinks, Timothy S.C., Howarth, Peter H., Vaarala, Outi, van Geest, Marleen, Olsson, Henric, Ahmed, H., Auffray, C., Bakke, P., Bansal, A.T., Bates, S., Bel, E.H., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, F.K., Corfield, J., D'Amico, A., De Meulder, B., Djukanovic, R., Fichtner, K., Fleming, L.J., Formaggio, E., Frey, U., Goss, V., Guo, Y., Hashimoto, S., Haughney, J., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., Horváth, I., James, A.J., Knowles, R., Loza, M.J., Manta, A., Matthews, J.G., Mazein, A., Meiser, A., Middelveld, R.J.M., Miralpeix, M., Montuschi, P., Murray, C.S., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Postle, A., Powel, P., Praticò, G., Riley, J., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Aalderen, W.M., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

Volltext

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months von Abdel-Aziz, Mahmoud I., Brinkman, Paul, Vijverberg, Susanne J.H., Neerincx, Anne H., Riley, John H., Bates, Stewart, Hashimoto, Simone, Kermani, Nazanin Zounemat, Chung, Kian Fan, Djukanovic, Ratko, Dahlén, Sven-Erik, Adcock, Ian M., Howarth, Peter H., Sterk, Peter J., Kraneveld, Aletta D., Maitland-van der Zee, Anke H.

Volltext

The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps von Gevaert, Philippe, Han, Joseph K., Smith, Steven G., Sousa, Ana R., Howarth, Peter H., Yancey, Steven W., Chan, Robert, Bachert, Claus

Volltext

Pathway discovery using transcriptomic profiles in adult-onset severe asthma von Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Adcock, I.M., Auffray, C., Bakke, P., Bansal, A.T., Baribaud, F., Bates, S., Bel, E.H., Bigler, J., Bisgaard, H., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Burg, D., Caruso, M., Chanez, P., Chung, F.K., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., De Meulder, B., Erpenbeck, V.J., Erzen, D., Fichtner, K., Fitch, N., Formaggio, E., Frey, U., Gahlemann, M., Geiser, T., Hashimoto, S., Haughney, J., Hedlin, G., Hohlfeld, J.M., Holweg, C., Horváth, I., Howarth, P., Knowles, R., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Matthews, J.G., Mazein, A., Middelveld, R.J.M., Mores, N., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powel, P., Praticò, G., Valls, M Puig, Rao, N., Riley, J., Roberts, G., Rowe, A., Sandström, T., Seibold, W., Selby, A., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

Volltext

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis von Takahashi, Kentaro, Pavlidis, Stelios, Ng Kee Kwong, Francois, Hoda, Uruj, Rossios, Christos, Sun, Kai, Loza, Matthew, Baribaud, Fred, Chanez, Pascal, Fowler, Steve J, Horvath, Ildiko, Montuschi, Paolo, Singer, Florian, Musial, Jacek, Dahlen, Barbro, Dahlen, Sven-Eric, Krug, Norbert, Sandstrom, Thomas, Shaw, Dominic E, Lutter, Rene, Bakke, Per, Fleming, Louise J, Howarth, Peter H, Caruso, Massimo, Sousa, Ana R, Corfield, Julie, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Djukanovic, Ratko, Sterk, Peter J, Guo, Yike, Adcock, Ian M, Chung, Kian Fan

Volltext

Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma von Howarth, P H, Babu, K S, Arshad, H S, Lau, L, Buckley, M, McConnell, W, Beckett, P, Al Ali, M, Chauhan, A, Wilson, S J, Reynolds, A, Davies, D E, Holgate, S T

Volltext

Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study von Djukanovic, R, Brinkman, P, Kolmert, J, Gomez, C, Schofield, J, Brandsma, J, Shapanis, A, Skipp, PJS, Postle, A, Wheelock, C, Dahlen, SE, Sterk, PJ, Brown, T, Jackson, DJ, Mansur, A, Pavord, I, Patel, M, Brightling, C, Siddiqui, S, Bradding, P, Sabroe, I, Saralaya, D, Chishimba, L, Porter, J, Robinson, D, Fowler, S, Howarth, PH, Little, L, Oliver, T, Hill, K, Stanton, L, Allen, A, Ellis, D, Griffiths, G, Harrison, T, Akenroye, A, Lasky-Su, J, Heaney, L, Chaudhuri, R, Kurukulaaratchy, R

Volltext

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation von Delgado-Eckert, Edgar, James, Anna, Meier-Girard, Delphine, Kupczyk, Maciej, Andersson, Lars I., Bossios, Apostolos, Mikus, Maria, Ono, Junya, Izuhara, Kenji, Middelveld, Roelinde, Dahlén, Barbro, Gaga, Mina, Siafakas, Nikos M., Papi, Alberto, Beghe, Bianca, Joos, Guy, Rabe, Klaus F., Sterk, Peter J., Bel, Elisabeth H., Johnston, Sebastian L., Chanez, Pascal, Gjomarkaj, Mark, Howarth, Peter H., Niżankowska-Mogilnicka, Ewa, Dahlén, Sven-Erik, Frey, Urs

Volltext

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation von Sparreman Mikus, Maria, Kolmert, Johan, Andersson, Lars I, Östling, Jörgen, Knowles, Richard G, Gómez, Cristina, Ericsson, Magnus, Thörngren, John-Olof, Emami Khoonsari, Payam, Dahlén, Barbro, Kupczyk, Maciej, De Meulder, Bertrand, Auffray, Charles, Bakke, Per S, Beghe, Bianca, Bel, Elisabeth H, Caruso, Massimo, Chanez, Pascal, Chawes, Bo, Fowler, Stephen J, Gaga, Mina, Geiser, Thomas, Gjomarkaj, Mark, Horváth, Ildikó, Howarth, Peter H, Johnston, Sebastian L, Joos, Guy, Krug, Norbert, Montuschi, Paolo, Musial, Jacek, Niżankowska-Mogilnicka, Ewa, Olsson, Henric K, Papi, Alberto, Rabe, Klaus F, Sandström, Thomas, Shaw, Dominick E, Siafakas, Nikolaos M, Uhlén, Mathias, Riley, John H, Bates, Stewart, Middelveld, Roelinde J M, Wheelock, Craig E, Chung, Kian Fan, Adcock, Ian M, Sterk, Peter J, Djukanovic, Ratko, Nilsson, Peter, Dahlén, Sven-Erik, James, Anna

Volltext

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma von Kupczyk, M., Dahlén, B., Sterk, P. J., Nizankowska‐Mogilnicka, E., Papi, A., Bel, E. H., Chanez, P., Howarth, P. H., Holgate, S. T., Brusselle, G., Siafakas, N. M., Gjomarkaj, M., Dahlén, S.‐E.

Volltext

Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model von Andriotis, O. G., Chang, S. W., Vanleene, M., Howarth, P. H., Davies, D. E., Shefelbine, S. J., Buehler, M. J., Thurner, P. J.

Volltext

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma von Moffatt, Miriam F, Gut, Ivo G, Demenais, Florence, Strachan, David P, Bouzigon, Emmanuelle, Heath, Simon, von Mutius, Erika, Farrall, Martin, Lathrop, Mark, Cookson, William O.C.M

Volltext

Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U‐BIOPRED severe asthma study von Wilson, Susan J, Ward, Jonathan A, Pickett, Helen M, Baldi, Simonetta, Sousa, Ana R, Sterk, Peter J, Chung, Kian Fan, Djukanovic, Ratko, Dahlen, Barbro, Billing, Bo, Shaw, Dominick, Krug, Norbert, Sandstrӧm, Thomas, Brightling, Christopher, Howarth, Peter H

Volltext

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study von Wilson, Susan J, Ward, Jonathan A, Sousa, Ana R, Corfield, Julie, Bansal, Aruna T, De Meulder, Bertrand, Lefaudeux, Diane, Auffray, Charles, Loza, Matthew J, Baribaud, Frederic, Fitch, Neil, Sterk, Peter J, Chung, Kian Fan, Gibeon, David, Sun, Kai, Guo, Yi-Ke, Adcock, Ian, Djukanovic, Ratko, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick, Krug, Norbert, Hohlfeld, Jens, Sandström, Thomas, Howarth, Peter H

Volltext

Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey von Newson, R. B., Ree, R., Forsberg, B., Janson, C., Lötvall, J., Dahlén, S.‐E., Toskala, E. M., Bælum, J., Brożek, G. M., Kasper, L., Kowalski, M. L., Howarth, P. H., Fokkens, W. J., Bachert, C., Keil, T., Krämer, U., Bislimovska, J., Gjomarkaj, M., Loureiro, C., Burney, P. G. J., Jarvis, D.

Volltext

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort von Emma, Rosalia, Bansal, Aruna T, Kolmert, Johan, Wheelock, Craig E, Dahlen, Swen-Erik, Loza, Matthew J, De Meulder, Bertrand, Lefaudeux, Diane, Auffray, Charles, Dahlen, Barbro, Bakke, Per S, Chanez, Pascal, Fowler, Stephen J, Horvath, Ildiko, Montuschi, Paolo, Krug, Norbert, Sanak, Marek, Sandstrom, Thomas, Shaw, Dominick E, Fleming, Louise J, Djukanovic, Ratko, Howarth, Peter H, Singer, Florian, Sousa, Ana R, Sterk, Peter J, Corfield, Julie, Pandis, Ioannis, Chung, Kian F, Adcock, Ian M, Lutter, René, Fabbella, Lorena, Caruso, Massimo

Volltext

Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma von Tariq, K., Schofield, J.P.R., Nicholas, B.L., Burg, D., Brandsma, J., Bansal, A.T., Wilson, S.J., Lutter, R., Fowler, S.J., Bakke, Caruso, M., Dahlen, B., Horváth, I., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Geiser, T., Pandis, I., Sousa, A.R., Adcock, I.M., Shaw, D.E., Auffray, C., Howarth, P.H., Sterk, P.J., Chung, K.F., Skipp, P.J., Dimitrov, B., Djukanović, R.

Volltext

S88 Micrornas regulate genome-wide translation in severe asthma bronchial epithelial cells as revealed by frac-seq von Martinez-Nunez, RT, Rupani, H, Niranjan, M, Howarth, PH, Sanchez-Elsner, T

Volltext

Osteopontin is expressed and functional in human eosinophils von Puxeddu, I., Berkman, N., Ribatti, D., Bader, R., Haitchi, H. M., Davies, D. E., Howarth, P. H., Levi‐Schaffer, F.

Volltext

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities von Holgate, Stephen T., Holloway, John, Wilson, Susan, Howarth, Peter H., Haitchi, Hans Michael, Babu, Suresh, Davies, Donna E.

Volltext