Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines von France, Scott P., Aleku, Godwin A., Sharma, Mahima, Mangas‐Sanchez, Juan, Howard, Roger M., Steflik, Jeremy, Kumar, Rajesh, Adams, Ralph W., Slabu, Iustina, Crook, Robert, Grogan, Gideon, Wallace, Timothy W., Turner, Nicholas J.

Volltext

Extending the application of biocatalysis to meet the challenges of drug development von Devine, Paul N., Howard, Roger M., Kumar, Rajesh, Thompson, Matthew P., Truppo, Matthew D., Turner, Nicholas J.

Volltext

Multifunctional biocatalyst for conjugate reduction and reductive amination von Thorpe, Thomas W., Marshall, James R., Harawa, Vanessa, Ruscoe, Rebecca E., Cuetos, Anibal, Finnigan, James D., Angelastro, Antonio, Heath, Rachel S., Parmeggiani, Fabio, Charnock, Simon J., Howard, Roger M., Kumar, Rajesh, Daniels, David S. B., Grogan, Gideon, Turner, Nicholas J.

Volltext

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocataly... von France, Scott P, Hussain, Shahed, Hill, Andrew M, Hepworth, Lorna J, Howard, Roger M, Mulholland, Keith R, Flitsch, Sabine L, Turner, Nicholas J

Volltext

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N‑Heterocycles von Thorpe, Thomas W, France, Scott P, Hussain, Shahed, Marshall, James R, Zawodny, Wojciech, Mangas-Sanchez, Juan, Montgomery, Sarah L, Howard, Roger M, Daniels, David S. B, Kumar, Rajesh, Parmeggiani, Fabio, Turner, Nicholas J

Volltext

Probing the chemical ‘reactome’ with high-throughput experimentation data von King-Smith, Emma, Berritt, Simon, Bernier, Louise, Hou, Xinjun, Klug-McLeod, Jacquelyn L., Mustakis, Jason, Sach, Neal W., Tucker, Joseph W., Yang, Qingyi, Howard, Roger M., Lee, Alpha A.

Volltext

Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block von Schwarz, Anna, Hecko, Sebastian, Rudroff, Florian, Kohrt, Jeffrey T., Howard, Roger M., Winkler, Margit

Volltext

Parallel multi-droplet platform for reaction kinetics and optimization von Eyke, Natalie S, Schneider, Timo N, Jin, Brooke, Hart, Travis, Monfette, Sebastien, Hawkins, Joel M, Morse, Peter D, Howard, Roger M, Pfisterer, David M, Nandiwale, Kakasaheb Y, Jensen, Klavs F

Volltext

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination von France, Scott P., Howard, Roger M., Steflik, Jeremy, Weise, Nicholas J., Mangas‐Sanchez, Juan, Montgomery, Sarah L., Crook, Robert, Kumar, Rajesh, Turner, Nicholas J.

Volltext

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate von Gilio, Amelia K., Thorpe, Thomas W., Heyam, Alex, Petchey, Mark R., Pogrányi, Balázs, France, Scott P., Howard, Roger M., Karmilowicz, Michael J., Lewis, Russell, Turner, Nicholas, Grogan, Gideon

Volltext

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease von Gopalsamy, Ariamala, Aulabaugh, Ann E, Barakat, Amey, Beaumont, Kevin C, Cabral, Shawn, Canterbury, Daniel P, Casimiro-Garcia, Agustin, Chang, Jeanne S, Chen, Ming Z, Choi, Chulho, Dow, Robert L, Fadeyi, Olugbeminiyi O, Feng, Xidong, France, Scott P, Howard, Roger M, Janz, Jay M, Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H, King-Ahmad, Amanda, Knee, Kelly M, Kohrt, Jeffrey T, Limberakis, Chris, Liras, Spiros, Martinez, Carlos A, McClure, Kim F, Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J, O'Connell, Thomas N, Parikh, Mihir D, Piotrowski, David W, Plotnikova, Olga, Robinson, Ralph P, Sahasrabudhe, Parag V, Sharma, Raman, Thuma, Benjamin A, Vasa, Dipy, Wei, Liuqing, Wenzel, A Zane, Withka, Jane M, Xiao, Jun, Yayla, Hatice G

Volltext

Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)‑α-Heteroaryl Propionic Acids von Blakemore, Caroline A, France, Scott P, Samp, Lacey, Nason, Deane M, Yang, Eddie, Howard, Roger M, Coffman, Karen J, Yang, Qingyi, Smith, Aaron C, Evrard, Edelweiss, Li, Wei, Dai, Linlin, Yang, Lixia, Chen, Zhiguang, Zhang, Qingli, He, Fangyan, Zhang, Jiesen

Volltext

Operator-free HPLC automated method development guided by Bayesian optimization von Dixon, Thomas M, Williams, Jeanine, Besenhard, Maximilian, Howard, Roger M, MacGregor, James, Peach, Philip, Clayton, Adam D, Warren, Nicholas J, Bourne, Richard A

Volltext

Preparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology von Rowan, Andrew S., Moody, Thomas S., Howard, Roger M., Underwood, Toby J., Miskelly, Iain R., He, Yanan, Wang, Bo

Volltext

The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate von Assaf, Georges, Checksfield, Graham, Critcher, Doug, Dunn, Peter J, Field, Stuart, Harris, Laurence J, Howard, Roger M, Scotney, Gemma, Scott, Adam, Mathew, Suju, Walker, Geoffrey M. H, Wilder, Alexander

Volltext

Application of biocatalysis towards asymmetric reduction and hydrolytic desymmetrisation in the synthesis of a β-3 receptor agonist von BADLAND, Matthew, BURNS, Michael P, CARROLL, Robert J, HOWARD, Roger M, LAITY, Daniel, WYMER, Nathan J

Volltext

Development of an Asymmetric Hydrogenation Route to (S)-N-Boc-2,6-dimethyltyrosine von Praquin, Céline F. B, de Koning, Pieter D, Peach, Philip J, Howard, Roger M, Spencer, Sarah L

Volltext

Convergent Asymmetric Synthesis of Two Complex TRPV1 Antagonists von Butcher, Kenneth J, Denton, Steven M, Field, Stuart E, Gillmore, Adam T, Harbottle, Gareth W, Howard, Roger M, Laity, Daniel A, Ngono, Christian J, Pibworth, Benjamin A

Volltext

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines von France, Scott P., Aleku, Godwin A., Sharma, Mahima, Mangas‐Sanchez, Juan, Howard, Roger M., Steflik, Jeremy, Kumar, Rajesh, Adams, Ralph W., Slabu, Iustina, Crook, Robert, Grogan, Gideon, Wallace, Timothy W., Turner, Nicholas J.

Volltext

Machine learning directed multi-objective optimization of mixed variable chemical systems von Kershaw, Oliver J., Clayton, Adam D., Manson, Jamie A., Barthelme, Alexandre, Pavey, John, Peach, Philip, Mustakis, Jason, Howard, Roger M., Chamberlain, Thomas W., Warren, Nicholas J., Bourne, Richard A.

Volltext