Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling von Hosseini, Iraj, Gadkar, Kapil, Stefanich, Eric, Li, Chi-Chung, Sun, Liping L., Chu, Yu-Waye, Ramanujan, Saroja

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Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL von Susilo, Monica E., Li, Chi‐Chung, Gadkar, Kapil, Hernandez, Genevive, Huw, Ling‐Yuh, Jin, Jin Y., Yin, Shen, Wei, Michael C., Ramanujan, Saroja, Hosseini, Iraj

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APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study von Hosseini, Iraj, Mac Gabhann, Feilim

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Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy von Joslyn, Louis R., Huang, Weize, Miles, Dale, Hosseini, Iraj, Ramanujan, Saroja

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Quantitative Clinical Pharmacology of T‐Cell Engaging Bispecifics: Current Perspectives and Opportunities von Morcos, Peter N., Li, Junyi, Hosseini, Iraj, Li, Chi‐Chung

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gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application von Hosseini, Iraj, Feigelman, Justin, Gajjala, Anita, Susilo, Monica, Ramakrishnan, Vidya, Ramanujan, Saroja, Gadkar, Kapil

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Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection von Hosseini, Iraj, Gama, Lucio, Mac Gabhann, Feilim

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule von Hosseini, Iraj, Fleisher, Brett, Getz, Jennifer, Decalf, Jérémie, Kwong, Mandy, Ovacik, Meric, Bainbridge, Travis W, Moussion, Christine, Rao, Gautham K, Gadkar, Kapil, Kamath, Amrita V, Ramanujan, Saroja

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Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy von Hosseini, Iraj, Mac Gabhann, Feilim

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy von Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal

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Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities von Shemesh, Colby S., Hsu, Joy C., Hosseini, Iraj, Shen, Ben-Quan, Rotte, Anand, Twomey, Patrick, Girish, Sandhya, Wu, Benjamin

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Designing Stem-Cell Based Anti-HIV Therapies using Molecular-Detailed Multiscale Models von Hosseini, Iraj, Mac Gabhann, Feilim

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Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics von Lu, Dan, Yadav, Rajbharan, Holder, Patrick, Chiang, Eugene, Sanjabi, Shomyseh, Poon, Victor, Bernett, Matthew, Varma, Rajat, Liu, Ke, Leung, Irene, Bogaert, Liz, Desjarlais, John, Shivva, Vittal, Hosseini, Iraj, Ramanujan, Saroja

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Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells von Gampa, Gautham, Spinosa, Phillip, Getz, Jennifer, Zhong, Yu, Halpern, Wendy, Esen, Emel, Davies, John, Chou, Cassie, Kwong, Mandy, Wang, Yingyun, Arenzana, Teresita L., Shivva, Vittal, Huseni, Mahrukh, Hsieh, Robert, Schartner, Jill, Koerber, James T., Rutz, Sascha, Hosseini, Iraj

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Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy von Wu, Kai Connie, Adedeji, Adeyemi O., Zabka, Tanja S., Hosseini, Iraj, Kenkre, Radhika, Getz, Jennifer A., Nguyen, Tien, Decalf, Jérémie, Bainbridge, Travis W., Chilton, Jennifer A., Moussion, Christine C., Rao, Gautham K.

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"Digital twins elucidate critical role of T scm in clinical persistence of TCR-engineered cell therapy" von Joslyn, Louis R, Huang, Weize, Miles, Dale, Hosseini, Iraj, Ramanujan, Saroja

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Current practices for QSP model assessment: an IQ consortium survey von Chan, Jason R., Allen, Richard, Boras, Britton, Cabal, Antonio, Damian, Valeriu, Gibbons, Francis D., Gulati, Abhishek, Hosseini, Iraj, Kearns, Jeffrey D., Saito, Ryuta, Cucurull-Sanchez, Lourdes, Selimkhanov, Jangir, Stein, Andrew M., Umehara, Kenichi, Wang, Guanyu, Wang, Weirong, Neves-Zaph, Susana

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gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development von Hosseini, Iraj, Gajjala, Anita, Bumbaca Yadav, Daniela, Sukumaran, Siddharth, Ramanujan, Saroja, Paxson, Ricardo, Gadkar, Kapil

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Abstract B043: Systems pharmacology modeling of anti-CD20/CD3 T-cell dependent bispecific antibody and its application to clinical trial design von Hosseini, Iraj, Gadkar, Kapil, Stefanich, Eric, Li, Chi-Chung, Sun, Laura, Chu, Yu-Waye, Ramanujan, Saroja

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Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection: e0126843 von Hosseini, Iraj, Gama, Lucio, Gabhann, Feilim Mac

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