Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19 von Ziegler, Carly G.K., Miao, Vincent N., Owings, Anna H., Navia, Andrew W., Tang, Ying, Bromley, Joshua D., Lotfy, Peter, Sloan, Meredith, Laird, Hannah, Williams, Haley B., George, Micayla, Drake, Riley S., Christian, Taylor, Parker, Adam, Sindel, Campbell B., Burger, Molly W., Pride, Yilianys, Hasan, Mohammad, Abraham, George E., Senitko, Michal, Robinson, Tanya O., Shalek, Alex K., Glover, Sarah C., Horwitz, Bruce H., Ordovas-Montanes, Jose

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Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2 von Mysore, Vijayashree, Tahir, Suhail, Furuhashi, Kazuhiro, Arora, Jatin, Rosetti, Florencia, Cullere, Xavier, Yazbeck, Pascal, Sekulic, Miroslav, Lemieux, Madeleine E, Raychaudhuri, Soumya, Horwitz, Bruce H, Mayadas, Tanya N

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Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function von Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Al Adham, Ziad, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie S., Ebens, Christen L., Santos, Fernanda G.M.S., Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., Snapper, Scott B.

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Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment von Venkatesh, Deepak, Ernandez, Thomas, Rosetti, Florencia, Batal, Ibrahim, Cullere, Xavier, Luscinskas, Francis W., Zhang, Yuzhi, Stavrakis, George, García-Cardeña, Guillermo, Horwitz, Bruce H., Mayadas, Tanya N.

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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis von Ryzhakov, Grigory, West, Nathaniel R., Franchini, Fanny, Clare, Simon, Ilott, Nicholas E., Sansom, Stephen N., Bullers, Samuel J., Pearson, Claire, Costain, Alice, Vaughan-Jackson, Alun, Goettel, Jeremy A., Ermann, Joerg, Horwitz, Bruce H., Buti, Ludovico, Lu, Xin, Mukhopadhyay, Subhankar, Snapper, Scott B., Powrie, Fiona

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses von Liang, Spencer C., Latchman, Yvette E., Buhlmann, Janet E., Tomczak, Michal F., Horwitz, Bruce H., Freeman, Gordon J., Sharpe, Arlene H.

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WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis von Biswas, Amlan, Shouval, Dror S., Griffith, Alexandra, Goettel, Jeremy A., Field, Michael, Kang, Yu Hui, Konnikova, Liza, Janssen, Erin, Redhu, Naresh Singh, Thrasher, Adrian J., Chatila, Talal, Kuchroo, Vijay K., Geha, Raif S, Notarangelo, Luigi D., Pai, Sung-Yun, Horwitz, Bruce H., Snapper, Scott B.

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Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination von Nziza, Nadège, Deng, Yixiang, Wood, Lianna, Dhanoa, Navneet, Dulit-Greenberg, Naomi, Chen, Tina, Kane, Abigail S., Swank, Zoe, Davis, Jameson P., Demokritou, Melina, Chitnis, Anagha P., Fasano, Alessio, Edlow, Andrea G., Jain, Nitya, Horwitz, Bruce H., McNamara, Ryan P., Walt, David R., Lauffenburger, Douglas A., Julg, Boris, Shreffler, Wayne G., Alter, Galit, Yonker, Lael M.

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Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice von Poutahidis, Theofilos, Cappelle, Kelsey, Levkovich, Tatiana, Lee, Chung-Wei, Doulberis, Michael, Ge, Zhongming, Fox, James G, Horwitz, Bruce H, Erdman, Susan E

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CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor von El Sayed, Shorouk, Patik, Izabel, Redhu, Naresh S., Glickman, Jonathan N., Karagiannis, Konstantinos, El Naenaeey, El Sayed Y., Elmowalid, Gamal A., Abd El Wahab, Ashraf M., Snapper, Scott B., Horwitz, Bruce H.

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Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice von RAO, Varada P, POUTAHIDIS, Theofilos, ZHONGMING GE, NAMBIAR, Prashant R, BOUSSAHMAIN, Chakib, YAN YAN WANG, HORWITZ, Bruce H, FOX, James G, ERDMAN, Susan E

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Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor von Redhu, Naresh S, Bakthavatchalu, Vasudevan, Conaway, Evan A, Shouval, Dror S, Tsou, Amy, Goettel, Jeremy A, Biswas, Amlan, Wang, Chuanwu, Field, Michael, Muller, Werner, Bleich, Andre, Li, Ning, Gerber, Georg K, Bry, Lynn, Fox, James G, Snapper, Scott B, Horwitz, Bruce H

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Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation von Tsou, Amy M., Goettel, Jeremy A., Bao, Bin, Biswas, Amlan, Kang, Yu Hui, Redhu, Naresh S., Peng, Kaiyue, Putzel, Gregory G., Saltzman, Jeffrey, Kelly, Ryan, Gringauz, Jordan, Barends, Jared, Hatazaki, Mai, Frei, Sandra M., Emani, Rohini, Huang, Ying, Shen, Zeli, Fox, James G., Glickman, Jonathan N., Horwitz, Bruce H., Snapper, Scott B.

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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection von Ziegler, Carly G K, Owings, Anna H, Galeas-Pena, Michelle, Kazer, Samuel W, Miao, Vincent N, Navia, Andrew W, Tang, Ying, Bromley, Joshua D, Lotfy, Peter, Sloan, Meredith, Laird, Hannah, Williams, Haley B, George, Micayla, Drake, Riley S, Pride, Yilianys, Abraham, 3rd, George E, Senitko, Michal, Robinson, Tanya O, Diamond, Gill, Lionakis, Michail S, Shalek, Alex K, Ordovas-Montanes, Jose, Horwitz, Bruce H, Glover, Sarah C

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Nfkb1 inhibits LPS-induced IFN-β and IL-12 p40 production in macrophages by distinct mechanisms von Zhao, Xixing, Ross, Erik J, Wang, Yanyan, Horwitz, Bruce H

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Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency von Shouval, Dror S, Biswas, Amlan, Kang, Yu Hui, Griffith, Alexandra E, Konnikova, Liza, Mascanfroni, Ivan D, Redhu, Naresh S, Frei, Sandra M, Field, Michael, Doty, Andria L, Goldsmith, Jeffrey D, Bhan, Atul K, Loizides, Anthony, Weiss, Batia, Yerushalmi, Baruch, Yanagi, Tadahiro, Lui, Xiuli, Quintana, Francisco J, Muise, Aleixo M, Klein, Christoph, Horwitz, Bruce H, Glover, Sarah C, Bousvaros, Athos, Snapper, Scott B

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NF-κB p50 and p65 subunits control intestinal homeostasis von Gadjeva, Mihaela, Wang, Yanyan, Horwitz, Bruce H

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COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children von Tang, Ying, Boribong, Brittany P, Swank, Zoe N, Demokritou, Melina, Luban, Maria A F, Fasano, Alessio, Du, Michelle, Wolf, Rebecca L, Griffiths, Joseph, Shultz, John, Borberg, Ella, Chalise, Sujata, Gonzalez, Wanda I, Walt, David R, Yonker, Lael M, Horwitz, Bruce H

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Cytotoxic-T-Lymphocyte-Associated Antigen 4 Blockade Abrogates Protection by Regulatory T Cells in a Mouse Model of Microbially Induced Innate Immune-Driven Colitis von Watanabe, Koichiro, Rao, Varada P, Poutahidis, Theofilos, Rickman, Barry H, Ohtani, Masahiro, Xu, Shilu, Rogers, Arlin B, Ge, Zhongming, Horwitz, Bruce H, Fujioka, Toshio, Erdman, Susan E, Fox, James G

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Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation von Conaway, Evan A, de Oliveira, Dalila C, McInnis, Christine M, Snapper, Scott B, Horwitz, Bruce H

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