Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK1 Receptor Antagonist von Ashwood, Valerie A, Field, Mark J, Horwell, David C, Julien-Larose, Christine, Lewthwaite, Russell A, McCleary, Scott, Pritchard, Martyn C, Raphy, Jenny, Singh, Lakhbir

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Syntheses of novel heterocycles as anticancer agents von Chauhan, Prem M.S., Martins, Cristina J.A., Horwell, David C.

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A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging von Ley, Steven V., Massi, Alessandro, Rodríguez, Félix, Horwell, David C., Lewthwaite, Russell A., Pritchard, Martyn C., Reid, Alison M.

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Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA von MENZLER, S, BIKKER, J. A, SUMAN-CHAUHAN, N, HORWELL, D. C

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Highly selective .kappa.-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted cyclohexyl]arylacetamide derivativ... von Halfpenny, Paul R, Horwell, David C, Hughes, John, Hunter, John C, Rees, David C

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Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents von Bryans, Justin S, Davies, Natasha, Gee, Nicolas S, Dissanayake, Visaka U. K, Ratcliffe, Giles S, Horwell, David C, Kneen, Clare O, Morrell, Andrew I, Oles, Ryszard J, O'Toole, John C, Perkins, Gemma M, Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A

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Rationally designed "dipeptoid" analogs of CCK. .alpha.-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic prop... von Horwell, David C, Hughes, John, Hunter, John C, Pritchard, Martyn C, Richardson, Reginald S, Roberts, Edward, Woodruff, Geoffrey N

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Synthesis of a non-peptide analogue of omega-conotoxin MVIIA von Menzler, Stefan, Bikker, Jack A, Horwell, David C

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N- vs O-alkylation in 2(1H)-quinolinone derivatives von Guo, Zhao-Xia, Cammidge, Andrew N, McKillop, Alexander, Horwell, David C

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Dendroid Peptide Structural Mimetics of ω-Conotoxin MVIIA based on a 2(1 H)-Quinolinone Core von Guo, Zhao-Xia, Cammidge, Andrew N, Horwell, David C

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Use of a Dipeptide Chemical Library in the Development of Non-Peptide Tachykinin NK3 Receptor Selective Antagonists von Boden, Phil, Eden, Jon M, Hodgson, Julie, Horwell, David C, Hughes, John, McKnight, Alexander T, Lewthwaite, Russell A, Pritchard, Martyn C, Raphy, Jenny, Meecham, Ken, Ratcliffe, Giles S, Suman-Chauhan, Nirmala, Woodruff, Geoffrey N

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The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes von Horwell, David C., Howson, William, Ratcliffe, Giles S., Willems, Henriëtte M.G.

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Amide bond replacements incorporated into CCK-B selective "dipeptoids" von Fincham, Christopher I, Higginbottom, Michael, Hill, David R, Horwell, David C, O'Toole, John C, Ratcliffe, Giles S, Rees, David C, Roberts, Edward

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Synthesis of Conformationally Constrained Tryptophan Derivatives von Horwell, David C, Nichols, Paul D, Ratcliffe, Giles S, Roberts, Edward

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Design of non-peptide agonists and antagonists at neuropeptide receptors starting from the chemical structure of neuropeptides von Horwell, David C.

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Rational design of high affinity tachykinin NK1 receptor antagonists von Boyle, S, Guard, S, Higginbottom, M, Horwell, D C, Howson, W, McKnight, A T, Martin, K, Pritchard, M C, O'Toole, J, Raphy, J

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A structure-affinity study of the amino acid side-chains in neurotensin : N and C terminal deletions and Ala-scan von Henry, Jenny A., Horwell, David C., Meecham, Kenneth G., Rees, David C.

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Highly selective .kappa. opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide... von Clark, Colin R, Halfpenny, Paul R, Hill, Raymond G, Horwell, David C, Hughes, John, Jarvis, Terry C, Rees, David C, Schofield, David

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Highly selective .kappa.-opioid analgesics. 2. Synthesis and structure activity relationships of novel N-(2-aminocyclohexyl)arylacetamide derivatives von Halfpenny, Paul R, Hill, Raymond G, Horwell, David C, Hughes, John, Hunter, John C, Johnson, Stephen, Rees, David C

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The design of dipeptide helical mimetics: the synthesis and biological activity of trisubstituted indanes von Horwell, David C, Howson, William, Ratcliffe, Giles, Willems, Henriette

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