Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals von Thess, Andreas, Grund, Stefanie, Mui, Barbara L, Hope, Michael J, Baumhof, Patrick, Fotin-Mleczek, Mariola, Schlake, Thomas

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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs von Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J., Madden, Thomas D., Mui, Barbara L., Semple, Sean C., Tam, Ying K., Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A., van der Meel, Roy, Cullis, Pieter R.

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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes von Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew

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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies von Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Krammer, Florian, Hensley, Scott E., Weissman, Drew

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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge von Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew

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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated... von Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.

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Rational design of cationic lipids for siRNA delivery von Semple, Sean C, Akinc, Akin, Chen, Jianxin, Sandhu, Ammen P, Mui, Barbara L, Cho, Connie K, Sah, Dinah W Y, Stebbing, Derrick, Crosley, Erin J, Yaworski, Ed, Hafez, Ismail M, Dorkin, J Robert, Qin, June, Lam, Kieu, Rajeev, Kallanthottathil G, Wong, Kim F, Jeffs, Lloyd B, Nechev, Lubomir, Eisenhardt, Merete L, Jayaraman, Muthusamy, Kazem, Mikameh, Maier, Martin A, Srinivasulu, Masuna, Weinstein, Michael J, Chen, Qingmin, Alvarez, Rene, Barros, Scott A, De, Soma, Klimuk, Sandra K, Borland, Todd, Kosovrasti, Verbena, Cantley, William L, Tam, Ying K, Manoharan, Muthiah, Ciufolini, Marco A, Tracy, Mark A, de Fougerolles, Antonin, MacLachlan, Ian, Cullis, Pieter R, Madden, Thomas D, Hope, Michael J

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo von Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.

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mRNA mediates passive vaccination against infectious agents, toxins, and tumors von Thran, Moritz, Mukherjee, Jean, Pönisch, Marion, Fiedler, Katja, Thess, Andreas, Mui, Barbara L, Hope, Michael J, Tam, Ying K, Horscroft, Nigel, Heidenreich, Regina, Fotin‐Mleczek, Mariola, Shoemaker, Charles B, Schlake, Thomas

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Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core von Leung, Alex K. K, Hafez, Ismail M, Baoukina, Svetlana, Belliveau, Nathan M, Zhigaltsev, Igor V, Afshinmanesh, Elham, Tieleman, D. Peter, Hansen, Carl L, Hope, Michael J, Cullis, Pieter R

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Lipid Nanoparticle Systems for Enabling Gene Therapies von Cullis, Pieter R., Hope, Michael J.

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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema von Szőke, Dániel, Kovács, Gábor, Kemecsei, Éva, Bálint, László, Szoták-Ajtay, Kitti, Aradi, Petra, Styevkóné Dinnyés, Andrea, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Karikó, Katalin, Kataru, Raghu P., Hope, Michael J., Weissman, Drew, Mehrara, Babak J., Pardi, Norbert, Jakus, Zoltán

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Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines von Lutz, Johannes, Lazzaro, Sandra, Habbeddine, Mohamed, Schmidt, Kim Ellen, Baumhof, Patrick, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Heidenreich, Regina, Fotin-Mleczek, Mariola

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Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques von Pardi, Norbert, LaBranche, Celia C., Ferrari, Guido, Cain, Derek W., Tombácz, István, Parks, Robert J., Muramatsu, Hiromi, Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Polacino, Patricia, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Haynes, Barton F., Montefiori, David C., Hu, Shiu-Lok, Weissman, Drew

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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles von Mui, Barbara L, Tam, Ying K, Jayaraman, Muthusamy, Ansell, Steven M, Du, Xinyao, Tam, Yuen Yi C, Lin, Paulo JC, Chen, Sam, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Akinc, Akin, Maier, Martin A, Cullis, Pieter, Madden, Thomas D, Hope, Michael J

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Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells von Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R

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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination von Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew

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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses von Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew

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Extrusion Technique to Generate Liposomes of Defined Size von Mui, Barbara, Chow, Laurie, Hope, Michael J

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Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics von Maier, Martin A, Jayaraman, Muthusamy, Matsuda, Shigeo, Liu, Ju, Barros, Scott, Querbes, William, Tam, Ying K, Ansell, Steven M, Kumar, Varun, Qin, June, Zhang, Xuemei, Wang, Qianfan, Panesar, Sue, Hutabarat, Renta, Carioto, Mary, Hettinger, Julia, Kandasamy, Pachamuthu, Butler, David, Rajeev, Kallanthottathil G, Pang, Bo, Charisse, Klaus, Fitzgerald, Kevin, Mui, Barbara L, Du, Xinyao, Cullis, Pieter, Madden, Thomas D, Hope, Michael J, Manoharan, Muthiah, Akinc, Akin

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