PD-1 and PD-1 ligands: from discovery to clinical application von Okazaki, Taku, Honjo, Tasuku

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Cancer immunotherapies targeting the PD-1 signaling pathway von Iwai, Yoshiko, Hamanishi, Junzo, Chamoto, Kenji, Honjo, Tasuku

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The PD-1–PD-L pathway in immunological tolerance von Okazaki, Taku, Honjo, Tasuku

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PD-1 deficiency results in the development of fatal myocarditis in MRL mice von Wang, Jian, Okazaki, Il-mi, Yoshida, Taku, Chikuma, Shunsuke, Kato, Yu, Nakaki, Fumio, Hiai, Hiroshi, Honjo, Tasuku, Okazaki, Taku

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Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model von Zhang, Baihao, Chikuma, Shunsuke, Hori, Shohei, Fagarasan, Sidonia, Honjo, Tasuku

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Regulation of lymphocyte development by Notch signaling von Honjo, Tasuku, Tanigaki, Kenji

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STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation von Wang, Guanning, Tajima, Masaki, Honjo, Tasuku, Ohta, Akio

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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice von Al-Habsi, Muna, Chamoto, Kenji, Matsumoto, Ken, Nomura, Norimichi, Zhang, Baihao, Sugiura, Yuki, Sonomura, Kazuhiro, Maharani, Aprilia, Nakajima, Yuka, Wu, Yibo, Nomura, Yayoi, Menzies, Rosemary, Tajima, Masaki, Kitaoka, Koji, Haku, Yasuharu, Delghandi, Sara, Yurimoto, Keiko, Matsuda, Fumihiko, Iwata, So, Ogura, Toshihiko, Fagarasan, Sidonia, Honjo, Tasuku

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Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability von Husain, Afzal, Begum, Nasim A., Taniguchi, Takako, Taniguchi, Hisaaki, Kobayashi, Maki, Honjo, Tasuku

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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense von Honjo, Tasuku, Wei, Min, Shinkura, Reiko, Doi, Yasuko, Maruya, Mikako, Fagarasan, Sidonia

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PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells von Iwai, Yoshiko, Terawaki, Seigo, Honjo, Tasuku

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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice von Okazaki, Taku, Okazaki, Il-mi, Wang, Jian, Sugiura, Daisuke, Nakaki, Fumio, Yoshida, Taku, Kato, Yu, Fagarasan, Sidonia, Muramatsu, Masamichi, Eto, Tomoo, Hioki, Kyoji, Honjo, Tasuku

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HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression von Refaat, Ahmed M., Nakata, Mikiyo, Husain, Afzal, Kosako, Hidetaka, Honjo, Tasuku, Begum, Nasim A.

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Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining von Stanlie, Andre, Yousif, Ashraf S., Akiyama, Hideo, Honjo, Tasuku, Begum, Nasim A.

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APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination von Xu, Jianliang, Husain, Afzal, Hu, Wenjun, Honjo, Tasuku, Kobayashi, Maki

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Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombinatio... von Al Ismail, Azza, Husain, Afzal, Kobayashi, Maki, Honjo, Tasuku, Begum, Nasim A

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PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors von Lin, David Yin-wei, Tanaka, Yoshimasa, Iwasaki, Masashi, Gittis, Apostolos G, Su, Hua-Poo, Mikami, Bunzo, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro, Garboczi, David N

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Blocking S100A9-signaling is detrimental to the initiation of anti-tumor immunity von Demir, Melike Fusun, Lin, Yu-Hsien, Costa Cruz, Pedro Henrique, Tajima, Masaki, Honjo, Tasuku, Müller, Elisabeth

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A memoir of AID, which engraves antibody memory on DNA von Honjo, Tasuku

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RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase von Yin, Ziwei, Kobayashi, Maki, Hu, Wenjun, Higashi, Koichi, Begum, Nasim A., Kurokawa, Ken, Honjo, Tasuku

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