From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations von Veit, Gudio, Avramescu, Radu G, Chiang, Annette N, Houck, Scott A, Cai, Zhiwei, Peters, Kathryn W, Hong, Jeong S, Pollard, Harvey B, Guggino, William B, Balch, William E, Skach, William R, Cutting, Garry R, Frizzell, Raymond A, Sheppard, David N, Cyr, Douglas M, Sorscher, Eric J, Brodsky, Jeffrey L, Lukacs, Gergely L

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Mutation accumulation in H. sapiens F508del CFTR countermands dN/dS type genomic analysis von Hong, Jeong S, Tindall, Janice M, Tindall, Samuel R, Sorscher, Eric J

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Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations von Bharti, Nikhil, Santos, Leonardo, Davyt, Marcos, Behrmann, Stine, Eichholtz, Marie, Jimenez-Sanchez, Alejandro, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Albers, Suki, Ignatova, Zoya

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Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators von Wang, Wei, Hong, Jeong S, Rab, Andras, Sorscher, Eric J, Kirk, Kevin L

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Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule The... von Chung, W Joon, Goeckeler-Fried, Jennifer L, Havasi, Viktoria, Chiang, Annette, Rowe, Steven M, Plyler, Zackery E, Hong, Jeong S, Mazur, Marina, Piazza, Gary A, Keeton, Adam B, White, E Lucile, Rasmussen, Lynn, Weissman, Allan M, Denny, R Aldrin, Brodsky, Jeffrey L, Sorscher, Eric J

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Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts von Rab, Regina, Ehrhardt, Annette, Achyut, Bhagelu R., Joshi, Disha, Gilbert‐Ross, Melissa, Huang, Chunzi, Floyd, Katharine, Borovjagin, Anton V., Parker, William B., Sorscher, Eric J., Hong, Jeong S.

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Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases von Sabusap, Carleen M, Wang, Wei, McNicholas, Carmel M, Chung, W Joon, Fu, Lianwu, Wen, Hui, Mazur, Marina, Kirk, Kevin L, Collawn, James F, Hong, Jeong S, Sorscher, Eric J

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S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment von McClure, Michelle L, Wen, Hui, Fortenberry, James, Hong, Jeong S, Sorscher, Eric J

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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 von Bergelson, Jeffrey M., Cunningham, Jennifer A., Droguett, Gustavo, Kurt-Jones, Evelyn A., Krithivas, Anita, Hong, Jeong S., Horwitz, Marshall S., Crowell, Richard L., Finberg, Robert W.

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Engineered tRNAs suppress nonsense mutations in cells and in vivo von Albers, Suki, Allen, Elizabeth C., Bharti, Nikhil, Davyt, Marcos, Joshi, Disha, Perez-Garcia, Carlos G., Santos, Leonardo, Mukthavaram, Rajesh, Delgado-Toscano, Miguel Angel, Molina, Brandon, Kuakini, Kristen, Alayyoubi, Maher, Park, Kyoung-Joo Jenny, Acharya, Grishma, Gonzalez, Jose A., Sagi, Amit, Birket, Susan E., Tearney, Guillermo J., Rowe, Steven M., Manfredi, Candela, Hong, Jeong S., Tachikawa, Kiyoshi, Karmali, Priya, Matsuda, Daiki, Sorscher, Eric J., Chivukula, Pad, Ignatova, Zoya

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Cystic fibrosis precision therapeutics: Emerging considerations von Joshi, Disha, Ehrhardt, Annette, Hong, Jeong S., Sorscher, Eric J.

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Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis von Guimbellot, Jennifer S, Erickson, Stephen W, Mehta, Tapan, Wen, Hui, Page, Grier P, Sorscher, Eric J, Hong, Jeong S

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Making precision medicine personal for cystic fibrosis von Manfredi, Candela, Tindall, Janice M., Hong, Jeong S., Sorscher, Eric J.

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The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue von Sabusap, Carleen Mae, Joshi, Disha, Simhaev, Luba, Oliver, Kathryn E., Senderowitz, Hanoch, van Willigen, Marcel, Braakman, Ineke, Rab, Andras, Sorscher, Eric J., Hong, Jeong S.

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Elexacaftor/VX-445–mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics von Kim, Minsoo, McDonald, Eli Fritz, Sabusap, Carleen Mae P., Timalsina, Bibek, Joshi, Disha, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Plate, Lars

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Efficient Intracellular Processing of the Endogenous Cystic Fibrosis Transmembrane Conductance Regulator in Epithelial Cell Lines von Varga, Károly, Jurkuvenaite, Asta, Wakefield, John, Hong, Jeong S, Guimbellot, Jennifer S, Venglarik, Charles J, Niraj, Ashutosh, Mazur, Marina, Sorscher, Eric J, Collawn, James F, Bebök, Zsuzsa

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High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo von Huayamares, Sebastian G., Lokugamage, Melissa P., Rab, Regina, Da Silva Sanchez, Alejandro J., Kim, Hyejin, Radmand, Afsane, Loughrey, David, Lian, Liming, Hou, Yuning, Achyut, Bhagelu R., Ehrhardt, Annette, Hong, Jeong S., Sago, Cory D., Paunovska, Kalina, Echeverri, Elisa Schrader, Vanover, Daryll, Santangelo, Philip J., Sorscher, Eric J., Dahlman, James E.

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G551D mutation impairs PKA-dependent activation of CFTR channel that can be restored by novel GOF mutations von Wang, Wei, Fu, Lianwu, Liu, Zhiyong, Wen, Hui, Rab, Andras, Hong, Jeong S, Kirk, Kevin L, Rowe, Steven M

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VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level von Cui, Guiying, Stauffer, Brandon B., Imhoff, Barry R., Rab, Andras, Hong, Jeong S., Sorscher, Eric J., McCarty, Nael A.

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Slowing ribosome velocity restores folding and function of mutant CFTR von Oliver, Kathryn E, Rauscher, Robert, Mijnders, Marjolein, Wang, Wei, Wolpert, Matthew J, Maya, Jessica, Sabusap, Carleen M, Kesterson, Robert A, Kirk, Kevin L, Rab, Andras, Braakman, Ineke, Hong, Jeong S, Hartman, 4th, John L, Ignatova, Zoya, Sorscher, Eric J

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