Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice von Michalon, Aubin, Bruns, Andreas, Risterucci, Céline, Honer, Michael, Ballard, Theresa M, Ozmen, Laurence, Jaeschke, Georg, Wettstein, Joseph G, von Kienlin, Markus, Künnecke, Basil, Lindemann, Lothar

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Evolution of bombesin conjugates for targeted PET imaging of tumors von Zhang, Hanwen, Abiraj, Keelara, Thorek, Daniel L J, Waser, Beatrice, Smith-Jones, Peter M, Honer, Michael, Reubi, Jean Claude, Maecke, Helmut R

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Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase von Jeger, Simone, Zimmermann, Kurt, Blanc, Alain, Grünberg, Jürgen, Honer, Michael, Hunziker, Peter, Struthers, Harriet, Schibli, Roger

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Ionizing Radiation Antagonizes Tumor Hypoxia Induced by Antiangiogenic Treatment von RIESTERER, Oliver, HONER, Michael, JOCHUM, Wolfram, OEHLER, Christoph, AMETAMEY, Simon, PRUSCHY, Martin

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome von Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A, Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W, Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G, Hernández, Maria-Clemencia

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Antibody-Based In Vivo Imaging of Central Nervous System Targets-Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines von Bredack, Christoph, Edelmann, Martin R, Borroni, Edilio, Gobbi, Luca C, Honer, Michael

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mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex von Kelly, Elyza, Schaeffer, Samantha M, Dhamne, Sameer C, Lipton, Jonathan O, Lindemann, Lothar, Honer, Michael, Jaeschke, Georg, Super, Chloe E, Lammers, Stephen Ht, Modi, Meera E, Silverman, Jill L, Dreier, John R, Kwiatkowski, David J, Rotenberg, Alexander, Sahin, Mustafa

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Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice von Mochizuki, Takatoshi, Arrigoni, Elda, Marcus, Jacob N, Clark, Erika L, Yamamoto, Mihoko, Honer, Michael, Borroni, Edilio, Lowell, Bradford B, Elmquist, Joel K, Scammell, Thomas E

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γ-Aminobutyric Acid Type B Receptor Splice Variant Proteins GBR1a and GBR1b Are Both Associated with GBR2 in Situ and Display Differential Regional and Subcellular Distribution von Benke, Dietmar, Honer, Michael, Michel, Claudia, Mohler, Hanns, Bettler, Bernhard

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Molecular Imaging with PET von Ametamey, Simon M, Honer, Michael, Schubiger, Pius August

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CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor von Lindemann, Lothar, Jaeschke, Georg, Michalon, Aubin, Vieira, Eric, Honer, Michael, Spooren, Will, Porter, Richard, Hartung, Thomas, Kolczewski, Sabine, Büttelmann, Bernd, Flament, Christophe, Diener, Catherine, Fischer, Christophe, Gatti, Silvia, Prinssen, Eric P., Parrott, Neil, Hoffmann, Gerhard, Wettstein, Joseph G.

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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man von Hipp, Joerg F., Knoflach, Frederic, Comley, Robert, Ballard, Theresa M., Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L., Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W., Hernandez, Maria-Clemencia

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In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography von MUMPRECHT, Viviane, HONER, Michael, VIGL, Benjamin, PROULX, Steven T, TRACHSEL, Eveline, KASPAR, Manuela, BANZIGER-TOBLER, Nadja E, SCHIBLI, Roger, NERI, Dario, DETMAR, Michael

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523... von Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar

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Increased basal ganglia binding of (18) F-AV-1451 in patients with progressive supranuclear palsy von Smith, Ruben, Schain, Martin, Nilsson, Christer, Strandberg, Olof, Olsson, Tomas, Hägerström, Douglas, Jögi, Jonas, Borroni, Edilio, Schöll, Michael, Honer, Michael, Hansson, Oskar

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Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain von Kuwabara, Hiroto, Comley, Robert A, Borroni, Edilio, Honer, Michael, Kitmiller, Kelly, Roberts, Joshua, Gapasin, Lorena, Mathur, Anil, Klein, Gregory, Wong, Dean F

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Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease von Honer, Michael, Gobbi, Luca, Knust, Henner, Kuwabara, Hiroto, Muri, Dieter, Koerner, Matthias, Valentine, Heather, Dannals, Robert F, Wong, Dean F, Borroni, Edilio

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Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatmen... von ARIT, Matthias J. E, NOVAK-HOFER, Ilse, GAST, Daniela, GSCHWEND, Verena, MOLDENHAUER, Gerhard, GRÜNBERG, Jurgen, HONER, Michael, SCHUBIGER, P. August, ALTEVOGT, Peter, KRUGER, Achim

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Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy von Smith, Ruben, Schöll, Michael, Honer, Michael, Nilsson, Christer F., Englund, Elisabet, Hansson, Oskar

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Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects von Wong, Dean F, Comley, Robert A, Kuwabara, Hiroto, Rosenberg, Paul B, Resnick, Susan M, Ostrowitzki, Susanne, Vozzi, Cristina, Boess, Frank, Oh, Esther, Lyketsos, Constantine G, Honer, Michael, Gobbi, Luca, Klein, Gregory, George, Noble, Gapasin, Lorena, Kitzmiller, Kelly, Roberts, Josh, Sevigny, Jeff, Nandi, Ayon, Brasic, James, Mishra, Chakradhar, Thambisetty, Madhav, Mogekar, Abhay, Mathur, Anil, Albert, Marilyn, Dannals, Robert F, Borroni, Edilio

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