Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) von Stachel, Shawn J, Coburn, Craig A, Steele, Thomas G, Jones, Kristen G, Loutzenhiser, Elizabeth F, Gregro, Alison R, Rajapakse, Hemaka A, Lai, Ming-Tain, Crouthamel, Ming-Chih, Xu, Min, Tugusheva, Katherine, Lineberger, Janet E, Pietrak, Beth L, Espeseth, Amy S, Shi, Xiao-Ping, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Munshi, Sanjeev, Simon, Adam J, Kuo, Lawrence, Vacca, Joseph P

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Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases von Coburn, Craig A, Stachel, Shawn J, Li, Yue-Ming, Rush, Diane M, Steele, Thomas G, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Xu, Min, Huang, Qian, Lai, Ming-Tain, DiMuzio, Jillian, Crouthamel, Ming-Chih, Shi, Xiao-Ping, Sardana, Vinod, Chen, Zhongguo, Munshi, Sanjeev, Kuo, Lawrence, Makara, Gergely M, Annis, D. Allen, Tadikonda, Praveen K, Nash, Huw M, Vacca, Joseph P, Wang, Tong

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Conformationally biased P3 amide replacements of β-secretase inhibitors von Stachel, Shawn J., Coburn, Craig A., Steele, Thomas G., Crouthamel, Min-Chi, Pietrak, Beth L., Lai, Ming-Tain, Holloway, M. Katharine, Munshi, Sanjeev K., Graham, Samuel L., Vacca, Joseph P.

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BACE-1 inhibition by a series of ψ[CH 2NH] reduced amide isosteres von Coburn, Craig A., Stachel, Shawn J., Jones, Kristen G., Steele, Thomas G., Rush, Diane M., DiMuzio, Jillian, Pietrak, Beth L., Lai, Ming-Tain, Huang, Qian, Lineberger, Janet, Jin, Lixia, Munshi, Sanjeev, Katharine Holloway, M., Espeseth, Amy, Simon, Adam, Hazuda, Daria, Graham, Samuel L., Vacca, Joseph P.

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Rational design and synthesis of selective BACE-1 inhibitors von Brady, Stephen F., Singh, Satendra, Crouthamel, Ming-Chih, Holloway, M.Katharine, Coburn, Craig A., Garsky, Victor M., Bogusky, Michael, Pennington, Michael W., Vacca, Joseph P., Hazuda, Daria, Lai, Ming-Tain

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L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor von Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.

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L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor von DORSEY, B. D, LEVIN, R. B, LIN, J. H, CHEN, I.-W, HOLLOWAY, M. K, FITZGERALD, P. M. D, AXEL, M. G, OSTOVIC, D, ANDERSON, P. S, HUFF, J. R, MCDANIEL, S. L, VACCA, J. P, GUARE, J. P, DARKE, P. L, ZUGAY, J. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C

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A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site von Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny

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An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease:  Computational Analysis and X-ray Crystal Structure of the Enzyme Complex von Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Yao, Wenquing, Sprengeler, Paul A, Holloway, M. Katharine, Kuo, Lawrence C, Chen, Zhongguo, Darke, Paul L, Schleif, William A

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Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors von Johnson, Timothy E., Holloway, M.Katharine, Vogel, Robert, Rutledge, Sue Jane, Perkins, James J., Rodan, Gideon A., Schmidt, Azriel

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X-ray crystal structure of the HIV protease complex with L-700,417, an inhibitor with pseudo C2 symmetry von Bone, Roger, Vacca, Joseph P, Anderson, Paul S, Holloway, M. Katharine

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SYNTHESIS AND ANTIVIRAL ACTIVITY OF A SERIES OF HIV-1 PROTEASE INHIBITORS WITH FUNCTIONALITY TETHERED TO THE P1 OR P1' PHENYL SUBSTITUENTS - X-RAY CRYSTAL-STRUCTURE ASSISTED DESIGN von THOMPSON, WJ, FITZGERALD, PMD, HOLLOWAY, MK, EMINI, EA, DARKE, PL, MCKEEVER, BM, SCHLEIF, WA, QUINTERO, JC, ZUGAY, JA, TUCKER, TJ, SCHWERING, JE, HOMNICK, CF, NUNBERG, J, SPRINGER, JP, HUFF

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L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor von Dorsey, Bruce D, Levin, Rhonda B, McDaniel, Stacy L, Vacca, Joseph P, Guare, James P, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A

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Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family von Schmidt, Azriel, Vogel, Robert, Holloway, M.Katharine, Rutledge, Su Jane, Friedman, Oren, Yang, Zhelin, Rodan, Gideon A, Friedman, Eitan

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Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport von Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Akaishi, Ryouichi, Guzman, Mark C, Jones, David R, Keenan, Terence P, Sprengeler, Paul A, Darke, Paul L

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A simple method for visualizing the differences between related receptor sites von Sheridan, Robert P, Holloway, M.Katharine, McGaughey, Georgia, Mosley, Ralph T, Singh, Suresh B

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Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin von Jayasuriya, Hiranthi, Salituro, Gino M., Smith, Scott K., Heck, James V., Gould, Steven J., Singh, Sheo B., Homnick, Carl F., Holloway, M.Katharine, Pitzenberger, Steven M., Patane, Michael A.

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Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease von DiIanni, C L, Davis, L J, Holloway, M K, Herber, W K, Darke, P L, Kohl, N E, Dixon, R A

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3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease von Thompson, Wayne J, Ghosh, Arun K, Holloway, M. Katharine, Lee, Hee Yoon, Munson, Peter M, Schwering, John E, Wai, Jenny, Darke, Paul L, Zugay, Joan

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Design and synthesis of nonpeptide peptidomimetic inhibitors of renin von Smith III, Amos B., Akaishi, Ryouichi, Jones, David R., Keenam, Terence P., Guzman, Mark C., Holcomb, Ryan C., Sprengeler, Paul A., Wood, John L., Hirschmann, Ralph, Holloway, M. Katharine

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