Turning the corner on therapeutic cancer vaccines von Hollingsworth, Robert E., Jansen, Kathrin

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Interleukin-6 Stimulates Defective Angiogenesis von Gopinathan, Ganga, Milagre, Carla, Pearce, Oliver M T, Reynolds, Louise E, Hodivala-Dilke, Kairbaan, Leinster, David A, Zhong, Haihong, Hollingsworth, Robert E, Thompson, Richard, Whiteford, James R, Balkwill, Frances

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A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways von Rios-Doria, Jonathan, Sabol, Darrin, Chesebrough, Jon, Stewart, Dave, Xu, Linda, Tammali, Ravinder, Cheng, Li, Du, Qun, Schifferli, Kevin, Rothstein, Ray, Leow, Ching Ching, Heidbrink-Thompson, Jenny, Jin, Xiaofang, Gao, Changshou, Friedman, Jay, Wilkinson, Brandy, Damschroder, Melissa, Pierce, Andrew J, Hollingsworth, Robert E, Tice, David A, Michelotti, Emil F

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A New Bliss Independence Model to Analyze Drug Combination Data von Zhao, Wei, Sachsenmeier, Kris, Zhang, Lanju, Sult, Erin, Hollingsworth, Robert E., Yang, Harry

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IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence von Finkel, Kelsey A, Warner, Kristy A, Kerk, Samuel, Bradford, Carol R, McLean, Scott A, Prince, Mark E, Zhong, Haihong, Hurt, Elaine M, Hollingsworth, Robert E, Wicha, Max S, Tice, David A, Nör, Jacques E

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Cancer stem cell plasticity and tumor hierarchy von Cabrera, Marina Carla, Hollingsworth, Robert E, Hurt, Elaine M

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Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling von Michaud, Neil R, Wang, Youzhen, McEachern, Kristen A, Jordan, Jerold J, Mazzola, Anne Marie, Hernandez, Axel, Jalla, Sanjoo, Chesebrough, Jon W, Hynes, Mark J, Belmonte, Matthew A, Wang, Lidong, Kang, Jaspal S, Jovanovic, Jelena, Laing, Naomi, Jenkins, David W, Hurt, Elaine, Liang, Meina, Frantz, Christopher, Hollingsworth, Robert E, Simeone, Diane M, Blakey, David C, Bedian, Vahe

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Targeting CD73 in the tumor microenvironment with MEDI9447 von Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.

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Preclinical development of a vaccine-based immunotherapy regimen (VBIR) that induces potent and durable T cell responses to tumor-associated self-antigens von Cho, Helen, Binder, Joe, Weeratna, Risini, Dermyer, Michael, Dai, Stanley, Boccia, Antionio, Li, Wei, Li, Shangjin, Jooss, Karin, Merson, James, Hollingsworth, Robert E.

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Therapeutic Efficacy of Cancer Stem Cell Vaccines in the Adjuvant Setting von Hu, Yangyang, Lu, Lin, Xia, Yang, Chen, Xin, Chang, Alfred E, Hollingsworth, Robert E, Hurt, Elaine, Owen, John, Moyer, Jeffrey S, Prince, Mark E P, Dai, Fu, Bao, Yangyi, Wang, Yi, Whitfield, Joel, Xia, Jian-Chuan, Huang, Shiang, Wicha, Max S, Li, Qiao

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Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics von Thompson, Pamela, Fleming, Ryan, Bezabeh, Binyam, Huang, Fengying, Mao, Shenlan, Chen, Cui, Harper, Jay, Zhong, Haihong, Gao, Xizhe, Yu, Xiang-Qing, Hinrichs, Mary Jane, Reed, Molly, Kamal, Adeela, Strout, Patrick, Cho, Song, Woods, Rob, Hollingsworth, Robert E., Dixit, Rakesh, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

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A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors von Zhong, Haihong, Davis, April, Ouzounova, Maria, Carrasco, Rosa A, Chen, Cui, Breen, Shannon, Chang, Yong S, Huang, Jiaqi, Liu, Zheng, Yao, Yihong, Hurt, Elaine, Moisan, Jacques, Fung, Michael, Tice, David A, Clouthier, Shawn G, Xiao, Zhan, Wicha, Max S, Korkaya, Hasan, Hollingsworth, Robert E

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CD44 Modulates Smad1 Activation in the BMP-7 Signaling Pathway von Peterson, Richard S., Andhare, Roma A., Rousche, Kathleen T., Knudson, Warren, Wang, Weihua, Grossfield, Jami B., Thomas, Raymond O., Hollingsworth, Robert E., Knudson, Cheryl B.

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5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma von Kerk, Samuel A, Finkel, Kelsey A, Pearson, Alexander T, Warner, Kristy A, Zhang, Zhaocheng, Nör, Felipe, Wagner, Vivian P, Vargas, Pablo A, Wicha, Max S, Hurt, Elaine M, Hollingsworth, Robert E, Tice, David A, Nör, Jacques E

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MEDI-573, alone or in combination with mammalian target of rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas von Zhong, Haihong, Fazenbaker, Christine, Breen, Shannon, Chen, Cui, Huang, Jiaqi, Morehouse, Christopher, Yao, Yihong, Hollingsworth, Robert E

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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4 von Harper, Jay, Lloyd, Christopher, Dimasi, Nazzareno, Toader, Dorin, Marwood, Rose, Lewis, Leeanne, Bannister, David, Jovanovic, Jelena, Fleming, Ryan, D'Hooge, Francois, Mao, Shenlan, Marrero, Allison M, Korade, 3rd, Martin, Strout, Patrick, Xu, Linda, Chen, Cui, Wetzel, Leslie, Breen, Shannon, van Vlerken-Ysla, Lilian, Jalla, Sanjoo, Rebelatto, Marlon, Zhong, Haihong, Hurt, Elaine M, Hinrichs, Mary Jane, Huang, Keven, Howard, Philip W, Tice, David A, Hollingsworth, Robert E, Herbst, Ronald, Kamal, Adeela

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Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer von Milagre, Carla S, Gopinathan, Ganga, Everitt, Gemma, Thompson, Richard G, Kulbe, Hagen, Zhong, Haihong, Hollingsworth, Robert E, Grose, Richard, Bowtell, David D L, Hochhauser, Daniel, Balkwill, Frances R

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Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment von Laurent‐Matha, Valérie, Huesgen, Pitter F., Masson, Olivier, Derocq, Danielle, Prébois, Christine, Gary‐Bobo, Magali, Lecaille, Fabien, Rebière, Bertrand, Meurice, Guillaume, Oréar, Cédric, Hollingsworth, Robert E., Abrahamson, Magnus, Lalmanach, Gilles, Overall, Christopher M., Liaudet‐Coopman, Emmanuelle

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A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor Response von Xiao, Zhan, Carrasco, Rosa A, Schifferli, Kevin, Kinneer, Krista, Tammali, Ravinder, Chen, Hong, Rothstein, Ray, Wetzel, Leslie, Yang, Chunning, Chowdhury, Partha, Tsui, Ping, Steiner, Philipp, Jallal, Bahija, Herbst, Ronald, Hollingsworth, Robert E, Tice, David A

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EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter von van Vlerken, Lilian E., Kiefer, Christine M., Morehouse, Chris, Li, Ying, Groves, Chris, Wilson, Susan D., Yao, Yihong, Hollingsworth, Robert E., Hurt, Elaine M.

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