A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa von Lu, Genmin, DeGuzman, Francis R, Hollenbach, Stanley J, Karbarz, Mark J, Abe, Keith, Lee, Gail, Luan, Peng, Hutchaleelaha, Athiwat, Inagaki, Mayuko, Conley, Pamela B, Phillips, David R, Sinha, Uma

Volltext

The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer von Coffey, Greg, Betz, Andreas, DeGuzman, Francis, Pak, Yvonne, Inagaki, Mayuko, Baker, Dale C, Hollenbach, Stanley J, Pandey, Anjali, Sinha, Uma

Volltext

Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model von Lu, Genmin, Pine, Polly, Leeds, Janet M, DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J, Curnutte, John T, Conley, Pamela B

Volltext

Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis von Coffey, Greg, DeGuzman, Francis, Inagaki, Mayuko, Pak, Yvonne, Delaney, Suzanne M, Ives, Dan, Betz, Andreas, Jia, Zhaozhong J, Pandey, Anjali, Baker, Dale, Hollenbach, Stanley J, Phillips, David R, Sinha, Uma

Volltext

Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa von Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark

Volltext

Nitric Oxide-Releasing Macromolecule Exhibits Broad-Spectrum Antifungal Activity and Utility as a Topical Treatment for Superficial Fungal Infections von Stasko, Nathan, McHale, Kimberly, Hollenbach, Stanley J, Martin, Megan, Doxey, Ryan

Volltext

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious fa... von Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan

Volltext

Minimizing higher-order aggregation maximizes iron mobilization by small molecules von Blake, Andrew D., Chao, Jianhua, SantaMaria, Anna M., Ekaputri, Stella, Green, Kelsie J., Brown, Samantha T., Rakowski, Christopher K., Choi, Eun-Kyung, Aring, Luisa, Chen, Peng-Jui, Snead, Nicholas M., Matje, Douglas M., Geng, Tao, Octaviani, Angela, Bailey, Keith, Hollenbach, Stanley J., Fan, Timothy M., Seo, Young-Ah, Burke, Martin D.

Volltext

Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family von Pandey, Anjali, Volkots, Deborah L, Seroogy, Joseph M, Rose, Jack W, Yu, Jin-Chen, Lambing, Joseph L, Hutchaleelaha, Athiwat, Hollenbach, Stanley J, Abe, Keith, Giese, Neill A, Scarborough, Robert M

Volltext

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may pla... von LOKKER, Nathalie A, SULLIVAN, Carol M, HOLLENBACH, Stanley J, ISRAEL, Mark A, GIESE, Neill A

Volltext

The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia von Spurgeon, Stephen E, Coffey, Greg, Fletcher, Luke B, Burke, Russell, Tyner, Jeffrey W, Druker, Brian J, Betz, Andreas, DeGuzman, Francis, Pak, Yvonne, Baker, Dale, Pandey, Anjali, Hollenbach, Stanley J, Sinha, Uma, Loriaux, Marc M

Volltext

ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY von Sinha, Uma, Morganroth, Joel, Gretler, Daniel D, Hollenbach, Stanley J, Lambing, Joseph L

Volltext

Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (... von Heath, Julie A., Mehrotra, Mukund M., Chi, Shannon, Yu, Jin-Chen, Hutchaleelaha, Athiwat, Hollenbach, Stanley J., Giese, Neill A., Scarborough, Robert M., Pandey, Anjali

Volltext

Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis von Sinha, Uma, Ku, Paul, Malinowski, John, Zhu, Bing Yan, Scarborough, Robert M, Marlowe, Charles K, Wong, Paul W, Lin, Pei Hua, Hollenbach, Stanley J

Volltext

Design, synthesis and structure–Activity relationships of benzoxazinone-Based factor Xa inhibitors von Huang, Wenrong, Zhang, Penglie, Zuckett, Jingmei F, Wang, Lingyan, Woolfrey, John, Song, Yonghong, Jia, Zhaozhong J, Clizbe, Lane A, Su, Ting, Tran, Katherine, Huang, Brian, Wong, Paul, Sinha, Uma, Park, Gary, Reed, Andrea, Malinowski, John, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan

Volltext

Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors von Lu, Genmin, DeGuzman, Francis R., Lakhotia, Sanjay, Hollenbach, Stanley J, Phillips, David R, Sinha, Uma

Volltext

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs von PENGLIE ZHANG, LIANG BAO, LAMBING, Joseph L, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, GOLDMAN, Erick A, JIA, Zhaozhong J, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, PARK, Gary

Volltext

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity von PENGLIE ZHANG, LIANG BAO, HOLLENBACH, Stanley J, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, JIA, Zhaozhong J, WOOLFREY, John, ARFSTEN, Ann, EDWARDS, Susan, SINHA, Uma, HUTCHALEELAHA, Athiwat, LAMBING, Joseph L

Volltext

Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists von Mehrotra, Mukund M., Heath, Julie A., Smyth, Mark S., Pandey, Anjali, Rose, Jack W., Seroogy, Joseph M., Volkots, Deborah L., Nannizzi-Alaimo, Lisa, Park, Gary L., Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M.

Volltext

Inhibition of Purified Factor Xa Amidolytic Activity May Not Be Predictive of Inhibition of In Vivo Thrombosis: Implications for Identification of Therapeutically Active Inhibitors von Sinha, Uma, Lin, Pei Hua, Edwards, Susan T, Wong, Paul W, Zhu, Bingyan, Scarborough, Robert M, Su, Ting, Jia, Zhaozhong J, Song, Yonghong, Zhang, Penglie, Clizbe, Lane, Park, Gary, Reed, Andrea, Hollenbach, Stanley J, Malinowski, John, Arfsten, Ann E

Volltext