Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases von Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter

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Dysregulation of bacterial proteolytic machinery by a new class of antibiotics von Brötz-Oesterhelt, Heike, Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Ladel, Christoph, Schroeder, Werner, Hinzen, Berthold, Raddatz, Siegfried, Paulsen, Holger, Henninger, Kerstin, Bandow, Julia E, Sahl, Hans-Georg, Labischinski, Harald

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Evolution of the Manufacturing Route towards a Key Benzothiophen‐2‐yl‐Boronic Acid Building Block of Rogaratinib von Gries, Jörg, Platzek, Johannes, Paulsen, Holger

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Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones von Schirok, Hartmut, Alonso-Alija, Cristina, Benet-Buchholz, Jordi, Göller, Andreas H, Grosser, Rolf, Michels, Martin, Paulsen, Holger

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Scalable Synthesis of the Desoxy-biphenomycin B Core von Berwe, Mathias, Jöntgen, Winfried, Krüger, Jochen, Cancho-Grande, Yolanda, Lampe, Thomas, Michels, Martin, Paulsen, Holger, Raddatz, Siegfried, Weigand, Stefan

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The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor von Wender, Paul A, Badham, Neil F, Conway, Simon P, Floreancig, Paul E, Glass, Timothy E, Gränicher, Christian, Houze, Jonathan B, Jänichen, Jan, Lee, Daesung, Marquess, Daniel G, McGrane, Paul L, Meng, Wei, Mucciaro, Thomas P, Mühlebach, Michel, Natchus, Michael G, Paulsen, Holger, Rawlins, David B, Satkofsky, Jeffrey, Shuker, Anthony J, Sutton, James C, Taylor, Richard E, Tomooka, Katsuhiko

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Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism von Park, Eun Young, Rübsamen-Schaeff, Helga, Lee, Byung-Gil, Jeon, Hyesung, Sung, Kwang Hoon, Paulsen, Holger, Brötz-Oesterhelt, Heike, Song, Hyun Kyu, Lee, Kyung-Eun

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New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Re... von Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus

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Stereoselective Mukaiyama-Michael/Michael/Aldol Domino Cyclization as the Key Step in the Synthesis of Pentasubstituted Arenes: An Efficient Access to Highly Active Inhibitors of C... von Paulsen, Holger, Antons, Stefan, Brandes, Arndt, Lögers, Michael, Müller, Stephan Nicholas, Naab, Paul, Schmeck, Carsten, Schneider, Stephan, Stoltefuß, Jürgen

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Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine von Schirok, Hartmut, Paulsen, Holger, Kroh, Walter, Chen, Gang, Gao, Ping

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Chromanol derivatives—A novel class of CETP inhibitors von Vakalopoulos, Alexandros, Schmeck, Carsten, Thutewohl, Michael, Li, Volkhart, Bischoff, Hilmar, Lustig, Klemens, Weber, Olaf, Paulsen, Holger, Elias, Harry

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Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics von Hinzen, Berthold, Raddatz, Siegfried, Paulsen, Holger, Lampe, Thomas, Schumacher, Andreas, Häbich, Dieter, Hellwig, Veronica, Benet-Buchholz, Jordi, Endermann, Rainer, Labischinski, Harald, Brötz-Oesterhelt, Heike

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Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro- N 4-{3,5-difluoro-4-[(3-methyl-1 H -pyrrolo[2,3- b ]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine von Schirok, Hartmut, Paulsen, Holger, Kroh, Walter, Chen, Gang, Gao, Ping

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Synthesis and Derivatization of 3-Perfluoroalkyl-Substituted 7-Azaindoles von Schirok, Hartmut, Figueroa-Pérez, Santiago, Thutewohl, Michael, Paulsen, Holger, Kroh, Walter, Klewer, Dagmar

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Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors von Schirok, Hartmut, Kast, Raimund, Figueroa-Pérez, Santiago, Bennabi, Samir, Gnoth, Mark J., Feurer, Achim, Heckroth, Heike, Thutewohl, Michael, Paulsen, Holger, Knorr, Andreas, Hütter, Joachim, Lobell, Mario, Münter, Klaus, Geiß, Volker, Ehmke, Heimo, Lang, Dieter, Radtke, Martin, Mittendorf, Joachim, Stasch, Johannes-Peter

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Synthesis of the insect pheromone (+)-eldanoline by enantioselective homoaldol reaction von Paulsen, Holger, Hoppe, Dieter

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Cover Picture: Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases (ChemMedChem 8/2012) von Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter

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Bacterial proteolytic machinery unleashed by acyldepsipeptide antibiotics von Broetz‐Oesterhelt, Heike, Beyer, Dieter, Kroll, Hein‐Peter, Schroeder, Werner, Hinzen, Berthold, Paulsen, Holger, Raddatz, Siegfried, Bandow, Julia Elisabeth, Ruebsamen‐Waigmann, Helga, Sahl, Hans‐Georg, Labischinski, Harald

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Convenient Synthesis of Enantiomerically Enriched (Oxybutenyl)stannanes and Their Lewis Acid Catalyzed Homoaldol Reactions von Paulsen, Holger, Graeve, Claudia, Hoppe, Dieter

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Cover Picture: Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors (ChemMedChem 12/2008) von Schirok, Hartmut, Kast, Raimund, Figueroa-Pérez, Santiago, Bennabi, Samir, Gnoth, Mark J., Feurer, Achim, Heckroth, Heike, Thutewohl, Michael, Paulsen, Holger, Knorr, Andreas, Hütter, Joachim, Lobell, Mario, Münter, Klaus, Geiß, Volker, Ehmke, Heimo, Lang, Dieter, Radtke, Martin, Mittendorf, Joachim, Stasch, Johannes-Peter

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