Targeting the epigenetic regulation of antitumour immunity von Hogg, Simon J., Beavis, Paul A., Dawson, Mark A., Johnstone, Ricky W.

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The natural function of the malaria parasite’s chloroquine resistance transporter von Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.

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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer von Escobar-Hoyos, Luisa F., Penson, Alex, Kannan, Ram, Cho, Hana, Pan, Chun-Hao, Singh, Rohit K., Apken, Lisa H., Hobbs, G. Aaron, Luo, Renhe, Lecomte, Nicolas, Babu, Sruthi, Pan, Fong Cheng, Alonso-Curbelo, Direna, Morris, John P., Askan, Gokce, Grbovic-Huezo, Olivera, Ogrodowski, Paul, Bermeo, Jonathan, Saglimbeni, Joseph, Cruz, Cristian D., Ho, Yu-Jui, Lawrence, Sharon A., Melchor, Jerry P., Goda, Grant A., Bai, Karen, Pastore, Alessandro, Hogg, Simon J., Raghavan, Srivatsan, Bailey, Peter, Chang, David K., Biankin, Andrew, Shroyer, Kenneth R., Wolpin, Brian M., Aguirre, Andrew J., Ventura, Andrea, Taylor, Barry, Der, Channing J., Dominguez, Daniel, Kümmel, Daniel, Oeckinghaus, Andrea, Lowe, Scott W., Bradley, Robert K., Abdel-Wahab, Omar, Leach, Steven D.

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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1 von Hogg, Simon J., Vervoort, Stephin J., Deswal, Sumit, Ott, Christopher J., Li, Jason, Cluse, Leonie A., Beavis, Paul A., Darcy, Phillip K., Martin, Benjamin P., Spencer, Andrew, Traunbauer, Anna K., Sadovnik, Irina, Bauer, Karin, Valent, Peter, Bradner, James E., Zuber, Johannes, Shortt, Jake, Johnstone, Ricky W.

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Wind energy: UK experiences and offshore operational challenges von Crabtree, Christopher J, Zappalá, Donatella, Hogg, Simon I

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer von Vervoort, Stephin J., Welsh, Sarah A., Devlin, Jennifer R., Barbieri, Elisa, Knight, Deborah A., Offley, Sarah, Bjelosevic, Stefan, Costacurta, Matteo, Todorovski, Izabela, Kearney, Conor J., Sandow, Jarrod J., Fan, Zheng, Blyth, Benjamin, McLeod, Victoria, Vissers, Joseph H.A., Pavic, Karolina, Martin, Ben P., Gregory, Gareth, Demosthenous, Elena, Zethoven, Magnus, Kong, Isabella Y., Hawkins, Edwin D., Hogg, Simon J., Kelly, Madison J., Newbold, Andrea, Simpson, Kaylene J., Kauko, Otto, Harvey, Kieran F., Ohlmeyer, Michael, Westermarck, Jukka, Gray, Nathanael, Gardini, Alessandro, Johnstone, Ricky W.

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Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition von Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., Abdel-Wahab, Omar

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Proteomic discovery of chemical probes that perturb protein complexes in human cells von Lazear, Michael R., Remsberg, Jarrett R., Jaeger, Martin G., Rothamel, Katherine, Her, Hsuan-lin, DeMeester, Kristen E., Njomen, Evert, Hogg, Simon J., Rahman, Jahan, Whitby, Landon R., Won, Sang Joon, Schafroth, Michael A., Ogasawara, Daisuke, Yokoyama, Minoru, Lindsey, Garrett L., Li, Haoxin, Germain, Jason, Barbas, Sabrina, Vaughan, Joan, Hanigan, Thomas W., Vartabedian, Vincent F., Reinhardt, Christopher J., Dix, Melissa M., Koo, Seong Joo, Heo, Inha, Teijaro, John R., Simon, Gabriel M., Ghosh, Brahma, Abdel-Wahab, Omar, Ahn, Kay, Saghatelian, Alan, Melillo, Bruno, Schreiber, Stuart L., Yeo, Gene W., Cravatt, Benjamin F.

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The significance of bypass transition on the annual energy production of an offshore wind turbine von Duffy, Aidan, Ingram, Grant, Hogg, Simon

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Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma von Costacurta, Matteo, Vervoort, Stephin J., Hogg, Simon J., Martin, Benjamin P., Johnstone, Ricky W., Shortt, Jake

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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia von Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J., Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E., Cui, Daniel, Erickson, Caroline E., Tittley, Steven M., Penson, Alexander V., Knorr, Katherine, Stanley, Robert F., Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A., Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M., Bradley, Robert K., Abdel-Wahab, Omar

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NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia von Witkowski, Matthew T., Lee, Soobeom, Wang, Eric, Lee, Anna K., Talbot, Alexis, Ma, Chao, Tsopoulidis, Nikolaos, Brumbaugh, Justin, Zhao, Yaqi, Roberts, Kathryn G., Hogg, Simon J., Nomikou, Sofia, Ghebrechristos, Yohana E., Thandapani, Palaniraja, Mullighan, Charles G., Hochedlinger, Konrad, Chen, Weiqiang, Abdel-Wahab, Omar, Eyquem, Justin, Aifantis, Iannis

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Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia von Bjelosevic, Stefan, Gruber, Emily, Newbold, Andrea, Shembrey, Carolyn, Devlin, Jennifer R., Hogg, Simon J., Kats, Lev, Todorovski, Izabela, Fan, Zheng, Abrehart, Thomas C., Pomilio, Giovanna, Wei, Andrew, Gregory, Gareth P., Vervoort, Stephin J., Brown, Kristin K., Johnstone, Ricky W.

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E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trial von Bewersdorf, Jan Philipp, Stahl, Maximilian, Taylor, Justin, Mi, Xiaoli, Chandhok, Namrata Sonia, Watts, Justin, Derkach, Andriy, Wysocki, Mateusz, Lu, Sydney X., Bourcier, Jessie, Hogg, Simon J., Rahman, Jahan, Chaudhry, Sana, Totiger, Tulasigeri M., Abdel-Wahab, Omar, Stein, Eytan M.

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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members von Hogg, Simon J, Newbold, Andrea, Vervoort, Stephin J, Cluse, Leonie A, Martin, Benjamin P, Gregory, Gareth P, Lefebure, Marcus, Vidacs, Eva, Tothill, Richard W, Bradner, James E, Shortt, Jake, Johnstone, Ricky W

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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies von Benbarche, Salima, Pineda, Jose Mario Bello, Galvis, Laura Baquero, Biswas, Jeetayu, Liu, Bo, Wang, Eric, Zhang, Qian, Hogg, Simon J., Lyttle, Kadeen, Dahi, Ariana, Lewis, Alexander M., Sarchi, Martina, Rahman, Jahan, Fox, Nina, Ai, Yuxi, Mehta, Sanjoy, Garippa, Ralph, Ortiz-Pacheco, Juliana, Li, Zhuoning, Monetti, Mara, Stanley, Robert F., Doulatov, Sergei, Bradley, Robert K., Abdel-Wahab, Omar

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Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation von Chen, Sisi, Vedula, Rahul S, Cuevas-Navarro, Antonio, Lu, Bin, Hogg, Simon J, Wang, Eric, Benbarche, Salima, Knorr, Katherine, Kim, Won Jun, Stanley, Robert F, Cho, Hana, Erickson, Caroline, Singer, Michael, Cui, Dan, Tittley, Steven, Durham, Benjamin H, Pavletich, Tatiana S, Fiala, Elise, Walsh, Michael F, Inoue, Daichi, Monette, Sebastien, Taylor, Justin, Rosen, Neal, McCormick, Frank, Lindsley, R Coleman, Castel, Pau, Abdel-Wahab, Omar

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Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia von So, Joan, Lewis, Alexander C, Smith, Lorey K, Stanley, Kym, Franich, Rheana, Yoannidis, David, Pijpers, Lizzy, Dominguez, Pilar, Hogg, Simon J, Vervoort, Stephin J, Brown, Fiona C, Johnstone, Ricky W, McDonald, Gabrielle, Ulanet, Danielle B, Murtie, Josh, Gruber, Emily, Kats, Lev M

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Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma von Oh, Danielle H, Ma, Xiao, Hogg, Simon J, He, Jackson, Kearney, Conor, Brasacchio, Daniella, Susanto, Olivia, Maher, Belinda, Jennings, Ian G, Newbold, Andrea, Fraser, Peter, Gruber, Emily, Kats, Lev M, Gregory, Gareth P, Johnstone, Ricky W, Thompson, Philip E, Shortt, Jake

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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity von Djajawi, Tirta M., Pijpers, Lizzy, Srivaths, Akash, Chisanga, David, Chan, Kok Fei, Hogg, Simon J., Neil, Liam, Rivera, Sarahi Mendoza, Bartonicek, Nenad, Ellis, Sarah L., Lim Kam Sian, Terry C.C., Faridi, Pouya, Liao, Yang, Pal, Bhupinder, Behren, Andreas, Shi, Wei, Vervoort, Stephin J., Johnstone, Ricky W., Kearney, Conor J.

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