Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure von Abplanalp, Wesley Tyler, Cremer, Sebastian, John, David, Hoffmann, Jedrzej, Schuhmacher, Bianca, Merten, Maximillian, Rieger, Michael A., Vasa-Nicotera, Mariuca, Zeiher, Andreas M., Dimmeler, Stefanie

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Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations von Assmus, Birgit, Cremer, Sebastian, Kirschbaum, Klara, Culmann, David, Kiefer, Katharina, Dorsheimer, Lena, Rasper, Tina, Abou-El-Ardat, Khalil, Herrmann, Eva, Berkowitsch, Alexander, Hoffmann, Jedrzej, Seeger, Florian, Mas-Peiro, Silvia, Rieger, Michael A, Dimmeler, Stefanie, Zeiher, Andreas M

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Post-myocardial infarction heart failure dysregulates the bone vascular niche von Hoffmann, Jedrzej, Luxán, Guillermo, Abplanalp, Wesley Tyler, Glaser, Simone-Franziska, Rasper, Tina, Fischer, Ariane, Muhly-Reinholz, Marion, Potente, Michael, Assmus, Birgit, John, David, Zeiher, Andreas Michael, Dimmeler, Stefanie

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DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts von Shumliakivska, Mariana, Luxán, Guillermo, Hemmerling, Inga, Scheller, Marina, Li, Xue, Müller-Tidow, Carsten, Schuhmacher, Bianca, Sun, Zhengwu, Dendorfer, Andreas, Debes, Alisa, Glaser, Simone-Franziska, Muhly-Reinholz, Marion, Kirschbaum, Klara, Hoffmann, Jedrzej, Nagel, Eike, Puntmann, Valentina O., Cremer, Sebastian, Leuschner, Florian, Abplanalp, Wesley Tyler, John, David, Zeiher, Andreas M., Dimmeler, Stefanie

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Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis von Dorsheimer, Lena, Assmus, Birgit, Rasper, Tina, Ortmann, Christina A, Abou-El-Ardat, Khalil, Kiefer, Katharina C, Hoffmann, Jedrzej, Seeger, Florian, Bonig, Halvard, Dimmeler, Stefanie, Zeiher, Andreas M, Rieger, Michael A

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Release Kinetics of Inflammatory Biomarkers in a Clinical Model of Acute Myocardial Infarction von Liebetrau, Christoph, Hoffmann, Jedrzej, Dörr, Oliver, Gaede, Luise, Blumenstein, Johannes, Biermann, Hannes, Pyttel, Lukas, Thiele, Peter, Troidl, Christian, Berkowitsch, Alexander, Rolf, Andreas, Voss, Sandra, Hamm, Christian W, Nef, Holger, Möllmann, Helge

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Senescent cytotoxic T cells in acute myocardial infarction： innocent bystanders or the horsemen of apocalypse von Hoffmann, Jedrzej, Spyridopoulos, Ioakim

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Endogenous developmental endothelial locus-1 limits ischaemia- related angiogenesis by blocking inflammation von Klotzsche - von Ameln, Anne, Cremer, Sebastian, Hoffmann, Jedrzej, Schuster, Peggy, Khedr, Sherif, Korovina, Irina, Troullinaki, Maria, Neuwirth, Ales, Sprott, David, Chatzigeorgiou, Antonios, Economopoulou, Matina, Orlandi, Alessia, Hain, Andreas, Zeiher, Andreas M., Deussen, Andreas, Hajishengallis, George, Dimmeler, Stefanie, Chavakis, Triantafyllos, Chavakis, Emmanouil

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Inflammatory signatures are associated with increased mortality after transfemoral transcatheter aortic valve implantation von Hoffmann, Jedrzej, Mas‐Peiro, Silvia, Berkowitsch, Alexander, Boeckling, Felicitas, Rasper, Tina, Pieszko, Konrad, De Rosa, Roberta, Hiczkiewicz, Jarosław, Burchardt, Paweł, Fichtlscherer, Stephan, Zeiher, Andreas M., Dimmeler, Stefanie, Nicotera, Mariuca Vasa

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High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction von Hoffmann, Jedrzej, Fiser, Karel, Weaver, Jolanta, Dimmick, Ian, Loeher, Monika, Pircher, Hanspeter, Martin-Ruiz, Carmen, Veerasamy, Murugapathy, Keavney, Bernard, von Zglinicki, Thomas, Spyridopoulos, Ioakim

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Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction von Hoffmann, Jedrzej, Ospelt, Manuel, Troidl, Christian, Voss, Sandra, Liebetrau, Christoph, Kim, Won-Keun, Rolf, Andreas, Wietelmann, Astrid, Braun, Thomas, Troidl, Kerstin, Sadayappan, Sakthivel, Barefield, David, Hamm, Christian, Nef, Holger, Möllmann, Helge

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Telomerase as a Therapeutic Target in Cardiovascular Disease von Hoffmann, Jedrzej, Richardson, Gavin, Haendeler, Judith, Altschmied, Joachim, Andrés, Vicente, Spyridopoulos, Ioakim

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Molecular basis of disturbed extracellular matrix homeostasis in stress cardiomyopathy von Szardien, Sebastian, Möllmann, Helge, Willmer, Matthias, Liebetrau, Christoph, Voss, Sandra, Troidl, Christian, Hoffmann, Jedrzej, Rixe, Johannes, Elsässer, Albrecht, Hamm, Christian W, Nef, Holger M

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Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation von Mas-Peiro, Silvia, Hoffmann, Jedrzej, Fichtlscherer, Stephan, Dorsheimer, Lena, Rieger, Michael A, Dimmeler, Stefanie, Vasa-Nicotera, Mariuca, Zeiher, Andreas M

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Long-term cardiac pathology in individuals with mild initial COVID-19 illness von Puntmann, Valentina O., Martin, Simon, Shchendrygina, Anastasia, Hoffmann, Jedrzej, Ka, Mame Madjiguène, Giokoglu, Eleni, Vanchin, Byambasuren, Holm, Niels, Karyou, Argyro, Laux, Gerald S., Arendt, Christophe, De Leuw, Philipp, Zacharowski, Kai, Khodamoradi, Yascha, Vehreschild, Maria J. G. T., Rohde, Gernot, Zeiher, Andreas M., Vogl, Thomas J., Schwenke, Carsten, Nagel, Eike

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Single-cell RNA-sequencing reveals profound changes in circulating immune cells in patients with heart failure von Abplanalp, Wesley T, John, David, Cremer, Sebastian, Assmus, Birgit, Dorsheimer, Lena, Hoffmann, Jedrzej, Becker-Pergola, Graziella, Rieger, Michael A, Zeiher, Andreas M, Vasa-Nicotera, Mariuca, Dimmeler, Stefanie

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Abstract 13067: Chronic Ischemic Heart Failure Defines Immune Cell Activation Signatures From ScRNA-seq and Flow Cytometry With Implications for Cardiac Resident Cells von Merten, Maximilian, Rasper, Tina, Schuhmacher, Bianca, Cremer, Sebastian, Hoffmann, Jedrzej, Zeiher, Andreas M, Dimmeler, Stefanie, Abplanalp, Wesley T

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Chronic ischemic heart failure is defined by ongoing immune cell activation promoting inflammation and altered crosstalk with endothelial cells von Merten, Maximilian, Rasper, Tina, Schuhmacher, Bianca, Cremer, Sebastian, Zeiher, Andreas Michael, Hoffmann, Jedrzej, Abplanalp, Wesley Tyler, Dimmeler, Stefanie

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Telomerase As a Therapeutic Target in Cardiovascular Disease von Hoffmann, Jedrzej, Richardson, Gavin, Haendeler, Judith, Altschmied, Joachim, Andrés, Vicente, Spyridopoulos, Ioakim

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CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians von Martin-Ruiz, Carmen, Hoffmann, Jedrzej, Shmeleva, Evgeniya, Zglinicki, Thomas von, Richardson, Gavin, Draganova, Lilia, Redgrave, Rachael, Collerton, Joanna, Arthur, Helen, Keavney, Bernard, Spyridopoulos, Ioakim

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