Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases von Caldwell, Richard D, Qiu, Hui, Askew, Ben C, Bender, Andrew T, Brugger, Nadia, Camps, Montserrat, Dhanabal, Mohanraj, Dutt, Vikram, Eichhorn, Thomas, Gardberg, Anna S, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Healey, Brian, Hodous, Brian L, Huck, Bayard R, Johnson, Theresa L, Jones, Christopher, Jones, Reinaldo C, Mochalkin, Igor, Morandi, Federica, Nguyen, Ngan, Meyring, Michael, Potnick, Justin R, Santos, Dusica Cvetinovic, Schmidt, Ralf, Sherer, Brian, Shutes, Adam, Urbahns, Klaus, Follis, Ariele Viacava, Wegener, Ansgar A, Zimmerli, Simone C, Liu-Bujalski, Lesley

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Catalytic Asymmetric Staudinger Reactions to Form β-Lactams:  An Unanticipated Dependence of Diastereoselectivity on the Choice of the Nitrogen Substituent von Lee, Elaine C, Hodous, Brian L, Bergin, Enda, Shih, Crystal, Fu, Gregory C

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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines von PAYTON, Marc, BUSH, Tammy L, NHO NGUYEN, Hanh, OLIVIERI, Philip R, ROMERO, Karina, SCHENKEL, Laurie B, BAK, Annette, STANTON, Mary, DUSSAULT, Isabelle, PATEL, Vinod F, GEUNS-MEYER, Stephanie, RADINSKY, Robert, CHUNG, Grace, KENDALL, Richard L, ZIEGLER, Beth, EDEN, Patrick, MCELROY, Patricia, ROSS, Sandra, CEE, Victor J, DEAK, Holly L, HODOUS, Brian L

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Enantioselective Staudinger Synthesis of β-Lactams Catalyzed by a Planar-Chiral Nucleophile von Hodous, Brian L, Fu, Gregory C

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Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones von Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D

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Targeting kinases with precision von Gardino, Alexandra K., Evans, Erica K., Kim, Joseph L., Brooijmans, Natasja, Hodous, Brian L., Wolf, Beni, Lengauer, Christoph

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Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor von Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin

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Enantioselective Addition of Alcohols to Ketenes Catalyzed by a Planar-Chiral Azaferrocene:  Catalytic Asymmetric Synthesis of Arylpropionic Acids von Hodous, Brian L, Ruble, J. Craig, Fu, Gregory C

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Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase von Cee, Victor J., Cheng, Alan C., Romero, Karina, Bellon, Steve, Mohr, Christopher, Whittington, Douglas A., Bak, Annette, Bready, James, Caenepeel, Sean, Coxon, Angela, Deak, Holly L., Fretland, Jenne, Gu, Yan, Hodous, Brian L., Huang, Xin, Kim, Joseph L., Lin, Jasmine, Long, Alexander M., Nguyen, Hanh, Olivieri, Philip R., Patel, Vinod F., Wang, Ling, Zhou, Yihong, Hughes, Paul, Geuns-Meyer, Stephanie

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Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase von Cee, Victor J, Albrecht, Brian K, Geuns-Meyer, Stephanie, Hughes, Paul, Bellon, Steve, Bready, James, Caenepeel, Sean, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hodous, Brian L, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, McGowan, David, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Powers, David, Rose, Paul, Wang, Ling, Zhao, Huilin

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Blu-285, a Potent and Selective Inhibitor for Hematologic Malignancies with KIT Exon 17 Mutations von Evans, Erica, Gardino, Alexandra, Hodous, Brian, Davis, Alison, Zhu, Julia, Kohl, Nancy E., Lengauer, Christoph

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A precision therapy against cancers driven by KIT/PDGFRA mutations von Evans, Erica K, Gardino, Alexandra K, Kim, Joseph L, Hodous, Brian L, Shutes, Adam, Davis, Alison, Zhu, Xing Julia, Schmidt-Kittler, Oleg, Wilson, Doug, Wilson, Kevin, DiPietro, Lucian, Zhang, Yulian, Brooijmans, Natasja, LaBranche, Timothy P, Wozniak, Agnieszka, Gebreyohannes, Yemarshet Kelemework, Schöffski, Patrick, Heinrich, Michael C, DeAngelo, Daniel J, Miller, Stephen, Wolf, Beni, Kohl, Nancy, Guzi, Timothy, Lydon, Nicholas, Boral, Andy, Lengauer, Christoph

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First Selective KIT D816V Inhibitor for Patients with Systemic Mastocytosis von Evans, Erica K., Hodous, Brian L., Gardino, Alexandra, Zhu, Julia, Shutes, Adam, Davis, Alison, Kim, Joseph, Wilson, Kevin, Wilson, Doug, Zhang, Yulian, Kohl, Nancy E., Guzi, Timothy, Lengauer, Christoph

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Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidru... von Geuns-Meyer, Stephanie, Cee, Victor J., Deak, Holly L., Du, Bingfan, Hodous, Brian L., Nguyen, Hanh N., Olivieri, Philip R., Romero, Karina, Schenkel, Laurie B., Patel, Vinod F., Be, Xuhai, Bush, Tammy L., Chung, Grace, Eden, Patrick, Huang, Liyue, Kendall, Richard, Lin, Min-Hwa Jasmine, Radinsky, Robert, Ziegler, Beth, Payton, Marc

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COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT von Zhang, Yulian, Hodous, Brian L, Kim, Joseph L, Wilson, Douglas, Wilson, Kevin J

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PROCESS FOR PREPARING COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT von KIM, JOSEPH, WILSON, KEVIN, WILSON, DOUGLAS, ZHANG, YULIAN, HODOUS, BRIAN

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Compositions useful for treating disorders related to kit von Hodous Brian L

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Enantioselective staudinger synthesis of β-lactams catalyzed by a planar-chiral nucleophile1 von HODOUS, Brian L, FU, Gregory C

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PROCESS FOR PREPARING COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT von WILSON, Kevin, WILSON, Douglas, ZHANG, Yulian, KIM, Joseph, HODOUS, Brian

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Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity von DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian

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