Development of a potent small‐molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation von Ohoka, Nobumichi, Suzuki, Masanori, Uchida, Takuya, Tsukumo, Yoshinori, Yoshida, Masayuki, Inoue, Takao, Ohki, Hitoshi, Naito, Mikihiko

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Acceleration of Protein Degradation by 20S Proteasome-Binding Peptides Generated by In Vitro Artificial Evolution von Zhu, Yunhao, Shigeyoshi, Kaishin, Hayakawa, Yumiko, Fujiwara, Sae, Kishida, Masamichi, Ohki, Hitoshi, Horibe, Tomohisa, Shionyu, Masafumi, Mizukami, Tamio, Hasegawa, Makoto

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Discovery of novel tricyclic compounds as squalene synthase inhibitors von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Haginoya, Noriyasu, Itoh, Masao, Sugita, Kazuyuki, Usui, Hiroyuki, Suzuki, Makoto, Terayama, Koji, Kanda, Akira

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Systematic Research of Peptide Spacers Controlling Drug Release from Macromolecular Prodrug System, Carboxymethyldextran Polyalcohol−Peptide−Drug Conjugates von Shiose, Yoshinobu, Kuga, Hiroshi, Ohki, Hitoshi, Ikeda, Masahiro, Yamashita, Fumiyoshi, Hashida, Mitsuru

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Development of a potent small molecule degrader against oncogenic BRAF V600E protein that evades paradoxical MAPK activation von Ohoka, Nobumichi, Suzuki, Masanori, Uchida, Takuya, Tsukumo, Yoshinori, Yoshida, Masayuki, Inoue, Takao, Ohki, Hitoshi, Naito, Mikihiko

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Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity von Kawai, Junya, Toki, Tadashi, Ota, Masahiro, Inoue, Hidekazu, Takata, Yoshimi, Asahi, Takashi, Suzuki, Makoto, Shimada, Takashi, Ono, Kaori, Suzuki, Kanae, Takaishi, Sachiko, Ohki, Hitoshi, Matsui, Satoshi, Tsutsumi, Shinji, Hirota, Yasuhide, Nakayama, Kiyoshi

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Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein von Ohoka, Nobumichi, Suzuki, Masanori, Uchida, Takuya, Tsuji, Genichiro, Tsukumo, Yoshinori, Yoshida, Masayuki, Inoue, Takao, Demizu, Yosuke, Ohki, Hitoshi, Naito, Mikihiko

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Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold von Kawai, Junya, Ota, Masahiro, Ohki, Hitoshi, Toki, Tadashi, Suzuki, Makoto, Shimada, Takashi, Matsui, Satoshi, Inoue, Hidekazu, Sugihara, Chika, Matsuhashi, Norikazu, Matsui, Yumi, Takaishi, Sachiko, Nakayama, Kiyoshi

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Studies on 8-Methoxyquinolones : Synthesis and Antibacterial Activity of 7-(3-Amino-4-substituted)pyrrolidinyl Derivatives von KAWAKAMI, Katsuhiro, TAKAHASHI, Hisashi, OHKI, Hitoshi, KIMURA, Kenichi, MIYAUCHI, Satoru, MIYAUCHI, Rie, TAKEMURA, Makoto

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Discovery of DF-461, a Potent Squalene Synthase Inhibitor von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Ota, Masahiro, Haginoya, Noriyasu, Itoh, Masao, Shibata, Yoshihiro, Sugita, Kazuyuki, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Usui, Hiroyuki

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Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug... von Miyauchi, Rie, Kawakami, Katsuhiro, Ito, Masao, Matsuhashi, Norikazu, Ohki, Hitoshi, Inagaki, Hiroaki, Takahashi, Hisashi, Takemura, Makoto

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Correction to “Discovery of DF-461, a Potent Squalene Synthase Inhibitor” von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Ota, Masahiro, Haginoya, Noriyasu, Itoh, Masao, Shibata, Yoshihiro, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Sugita, Kazuyuki

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Synthesis and Structure−Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3... von Inagaki, Hiroaki, Miyauchi, Satoru, Miyauchi, Rie N, Kawato, Haruko C, Ohki, Hitoshi, Matsuhashi, Norikazu, Kawakami, Katsuhiro, Takahashi, Hisashi, Takemura, Makoto

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Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity von Ohki, Hitoshi, Hirotani, Kenji, Naito, Hiroyuki, Ohsuki, Satoru, Minami, Megumi, Ejima, Akio, Koiso, Yukiko, Hashimoto, Yuichi

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SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON von INOUE, Hidekazu, KAWAI, Junya, OHKI, Hitoshi, TOKI, Tadashi, OTA, Masahiro

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A facile, large-scale preparation of the methyl 2-thioglycoside of N-acetylneuraminic acid, and its usefulness for the α-stereoselective synthesis of sialoglycosides von Hasegawa, Akira, Ohki, Hitoshi, Nagahama, Takao, Ishida, Hideharu, Kiso, Makoto

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Sulfonamide derivative having coumarin skeleton von Inoue, Hidekazu, Toki, Tadashi, Ota, Masahiro, Kawai, Junya, Ohki, Hitoshi

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Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R, 2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxyli c acid antibacterials having fluorinated 7-[(3R)... von INAGAKI, Hiroaki, MIYAUCHI, Satoru, MIYAUCHI, Rie N, KAWATO, Haruko C, OHKI, Hitoshi, MATSUHASHI, Norikazu, KAWAKAMI, Katsuhiro, TAKAHASHI, Hisashi, TAKEMURA, Makoto

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SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON von INOUE, Hidekazu, KAWAI, Junya, OHKI, Hitoshi, TOKI, Tadashi, OTA, Masahiro

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SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON von INOUE, Hidekazu, KAWAI, Junya, OHKI, Hitoshi, TOKI, Tadashi, OTA, Masahiro

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