Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial von Yamada, Yuichiro, Katagiri, Hideki, Hamamoto, Yoshiyuki, Deenadayalan, Srikanth, Navarria, Andrea, Nishijima, Keiji, Seino, Yutaka, Fukushima, Y, Hamamoto, Y, Hisatomi, A, Ide, Y, Inoue, S, Kawada, T, Kim, H, Kiyosue, A, Matoba, K, Matsuoka, O, Nishimura, H, Noguchi, M, Osonoi, T, Sawada, S, Shibasaki, Y, Shin, K, Yamada, Y

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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies von Kaptoge, Stephen, Butterworth, Adam S, Willeit, Peter, Bolton, Thomas, Paige, Ellie, Paul, Dirk S, Bell, Steven, Astle, William, Verschuren, W M Monique, Sato, Shinichi, Njølstad, Inger, Salomaa, Veikko, Yeap, Bu B, Melander, Olle, Marmot, Michael, Dahm, Christina C, Dale, Caroline E, van der Schouw, Yvonne T, Simons, Leon A, Schoufour, Josje D, Key, Timothy J, Moreno-Iribas, Conchi, Davidson, Karina W, Taylor, James O, Wallace, Robert B, Tumino, Rosario, Linneberg, Allan, Panico, Salvatore, Nietert, Paul J, Kromhout, Daan, Kiechl, Stefan, Palli, Domenico, Huerta, José M, Karakatsani, Anna, Kühn, Tilman, Grobbee, Diederick E, Kauhanen, Jussi, Wennberg, Maria, Cushman, Mary, Cooper, Jackie A, Rodriguez, Carlos J, Shaw, Jonathan E, Voortman, Trudy, Dallongeville, Jean, Brunner, Eric J, Lazo, Mariana, Leon, David A, Smith, George Davey, Peto, Richard, Jackson, Rod, Banks, Emily, Butterworth, Adam, Warnakula, Samantha, Paige, Ellie, Bell, Steven, Astle, William, Sato, Shinichi, Veikko, Salomaa, Flecther, Astrid, Melander, Olle, Kuller, Lewis H, Koenig, Wolfgang, Casiglia, Edoardo, Arndt, Volker, Völzke, Henry, Dahm, Christina C, Dale, Caroline E, Bergmann, Manuela, Crespo, Carlos, Kaaks, Rudolf, Simons, Leon A, Lagiou, Pagona, Key, Timothy J, Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W, Quiros, J. Ramon, Skeie, Guri, Salomaa, Veikko, Strandberg, Timo, Nietert, Paul J, Salamanca-Fernandez, Elena, Krumholz, Harlan M, Price, Jackie, Travis, Ruth C, Kühn, Tilman, Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Forouhi, Nita, Wennberg, Maria, Brenner, Hermann, Assmann, Gerd, Trevisan, Maurizio, Gillumn, Richard F, Thompson, Simon, Ferrari, Pietro, Davey Smith, George

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Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial von Zinman, Bernard, Aroda, Vanita R, Buse, John B, Cariou, Bertrand, Harris, Stewart B, Hoff, Søren Tetens, Pedersen, Karen Boje, Tarp-Johansen, Mads Jeppe, Araki, Eiichi

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Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3... von Anderson, Craig S, Arima, Hisatomi, Chen, Guofang, Martins, Sheila O, Silva, Federico, Thang, Nguyen H, Arima, Hisatomi, Li, Qiang, Martins, Sheila O., Pontes-Neto, Octavio M., Wang, Xia, Simes, R. John, Hirakawa, Yoichiro, Moullaali, Tom J., Carcel, Cheryl, Gordon, Penny, Cao, Yongjun, Winters, Stephen, Zhang, Shihong, Manning, Lisa, Minhas, Jatinder, Malavera, Alejandra, Ivanova, Elizaveta, Armenis, Manuela, Blacklock, Nick, Naidu, Bala, Smith, Phillipa, Kong, Liang, Ebraimo, Ahtasam, Phuong, Do M., Tran, Nguyen T.B., Hoa, Nguyen A., Ray, E., Ng, G., Weiss, G., Titton, N., Castro, R., Fagundes, D., Alves, M., Rivas, R., Herrera, A., Zhou, S., Ping, L., Shi, J., Gong, P., Zhao, H., Li, R., Liu, D., Liang, L., Xia, J., Zhao, N., Huang, W., Zhang, A., Liu, H., Zhang, Y., Li, F., Huang, L., Zheng, R., Liu, J., Zhang, S., Liu, X., Lai, Y., Du, J., Wei, C., Li, W, Zeng, X., Wu, X., Castellanos, J.A., Raj, P.G., Parmar, M., Patel, D., Gorthi, S.P., Prabhu, A., Nair, R., TP, S., Choudhury, N., Duberkar, D., Sacchini, E., Padiglioni, C., Kim, J., Hwang, H.W., Kwon, S.U., Kim, Y.J., Kim, B., Kim, Y.W., Lee, J.J., Chang, H.M., Martínez, A., Lin, Y.J., Huang, Y.C., Dyker, A., Natarajan, I., Qadiri, M.R., Smith, C., James, M., Marsden, T., Price, C., Bergin, A., Le Kim, K., Le Thanh, T. Tran

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Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis von Grams, Morgan E, Coresh, Josef, Matsushita, Kunihiro, Ballew, Shoshana H, Sang, Yingying, Surapaneni, Aditya, Alencar de Pinho, Natalia, Anderson, Amanda, Appel, Lawrence J, Ärnlöv, Johan, Azizi, Fereidoun, Bansal, Nisha, Bell, Samira, Bilo, Henk J G, Brunskill, Nigel J, Carrero, Juan J, Chadban, Steve, Chalmers, John, Chen, Jing, Ciemins, Elizabeth, Cirillo, Massimo, Ebert, Natalie, Evans, Marie, Ferreiro, Alejandro, Fu, Edouard L, Fukagawa, Masafumi, Green, Jamie A, Gutierrez, Orlando M, Herrington, William G, Hwang, Shih-Jen, Inker, Lesley A, Iseki, Kunitoshi, Jafar, Tazeen, Jassal, Simerjot K, Jha, Vivekanand, Kadota, Aya, Katz, Ronit, Köttgen, Anna, Konta, Tsuneo, Kronenberg, Florian, Lee, Brian J, Lees, Jennifer, Levin, Adeera, Looker, Helen C, Major, Rupert, Melzer Cohen, Cheli, Mieno, Makiko, Miyazaki, Mariko, Moranne, Olivier, Muraki, Isao, Naimark, David, Nitsch, Dorothea, Oh, Wonsuk, Pena, Michelle, Purnell, Tanjala S, Sabanayagam, Charumathi, Satoh, Michihiro, Sawhney, Simon, Schaeffner, Elke, Schöttker, Ben, Shen, Jenny I, Shlipak, Michael G, Sinha, Smeeta, Stengel, Benedicte, Sumida, Keiichi, Tonelli, Marcello, Valdivielso, Jose M, van Zuilen, Arjan D, Visseren, Frank L J, Wang, Angela Yee-Moon, Wen, Chi-Pang, Wheeler, David C, Yatsuya, Hiroshi, Yamagata, Kunihiro, Yang, Jae Won, Young, Ann, Zhang, Haitao, Zhang, Luxia, Levey, Andrew S, Gansevoort, Ron T

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Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium von Chang, Alex R, Grams, Morgan E, Ballew, Shoshana H, Bilo, Henk, Correa, Adolfo, Evans, Marie, Gutierrez, Orlando M, Hosseinpanah, Farhad, Iseki, Kunitoshi, Kenealy, Timothy, Klein, Barbara, Kronenberg, Florian, Lee, Brian J, Li, Yuanying, Miura, Katsuyuki, Navaneethan, Sankar D, Roderick, Paul J, Valdivielso, Jose M, Visseren, Frank L J, Zhang, Luxia, Gansevoort, Ron T, Hallan, Stein I, Levey, Andrew S, Matsushita, Kunihiro, Shalev, Varda, Woodward, Mark

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Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies von Coresh, Josef, Sang, Yingying, Matsushita, Kunihiro, Arnlov, Johan, Black, Corri, Brunskill, Nigel J, Carrero, Juan-Jesus, Feldman, Harold I, Ishani, Areef, Ito, Sadayoshi, Jassal, Simerjot, Polkinghorne, Kevan, Romundstad, Solfrid, Solbu, Marit D, Stempniewicz, Nikita, Tonelli, Marcello, Umesawa, Mitsumasa, Waikar, Sushrut S, Wen, Chi-Pang, Wetzels, Jack F M, Woodward, Mark, Kovesdy, Csaba P, Levey, Andrew S, Greene, Tom, Chen, Teresa K, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Herrington, William G, Smith, Margaret, Hsu, C Yenchih, Chang, Alex R, Green, Jamie A, Ho, Kevin, Marks, Angharad, Prescott, Gordon, Clark, Laura E, Fluck, Nick, Shalev, Varda, Van Zuilen, Arjan, Van den Brand, Jan A, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen G, Nadukuru, Rajiv, Metzger, Marie, Houillier, Pascal, Haymann, Jean-Philippe, Froissart, Marc, Kenealy, Timothy, Elley, Raina C, Collins, John F, Drury, Paul L, Cuddeback, John K, Stempniewicz, Rich, Knowler, William C, Major, Rupert W, Medcalf, James F, Shepherd, David, Barrett-Connor, Elizabeth, Molnar, Miklos Z, Sumida, Keiichi, de Zeeuw, Dick, Qureshi, Abdul R, Elinder, Carl-Gustaf, Runesson, Bjorn, Evans, Marie, Segelmark, Marten, Schön, Staffan, Tangri, Navdeep, Hirayama, Atsushi, Ichikawa, Kazunobu, Bilo, Henk JG, Landman, Gijs WD, Van Hateren, Kornelis JJ, Kleefstra, Nanne, Ballew, Shoshana H, Chen, Jingsha, Rodby, Roger A., Rohde, Richard D, Lewis, Julia B, Lewis, Edmund, Perrone, Ronald D, Abebe, Kaleab Z, Hou, Fan F, Xie, Di, Hunsicker, Lawrence G, Imai, Enyu, Kobayashi, Fumiaki, Makino, Hirofumi, Remuzzi, Giuseppe, Eckardt, Kai-Uwe, Gudmundsdottir, Hrefna, Maciulaitis, Romaldas, Manley, Tom, Stockbridge, Norman, Thompson, Aliza

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Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke von Li, Gang, Lin, Yapeng, Yang, Jie, Anderson, Craig S., Chen, Chen, Liu, Feifeng, Billot, Laurent, Li, Qiang, Chen, Xiaoying, Liu, Xiaoqiu, Ren, Xinwen, Zhang, Chunfang, Xu, Ping, Wu, Lijun, Wang, Feng, Qiu, Daijun, Jiang, Mei, Peng, Yiqian, Li, Chaohui, Huang, Yiyang, Zhao, Xiaohui, Liang, Jiye, Wang, Yao, Wu, Xiangjun, Xu, Xiaoyun, Chen, Guofang, Huang, Dongya, Zhang, Yue, Zuo, Lian, Ma, Guozhao, Yang, Yumei, Hao, Junjie, Xu, Xiahong, Xiong, Xinli, Tang, Yueyu, Guo, Yijia, Yu, Jianping, Li, Shuping, He, Song, Mao, Fengkai, Tan, Quandan, Tan, Song, Yu, Nengwei, Xu, Ruxiang, Sun, Mingwei, Li, Binghu, Guo, Jiang, Liu, Leibo, Liu, Hueiming, Ouyang, Menglu, Si, Lei, Arima, Hisatomi, Bath, Philip M., Ford, Gary A., Robinson, Thompson, Sandset, Else Charlotte, Saver, Jeffrey L., Sprigg, Nikola, van der Worp, H. Bart, Song, Lili

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Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018

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Is Blood Pressure Lowering in the Very Elderly With Previous Stroke Associated With a Higher Risk of Adverse Events? von Tharmaratnam, Damien, Karayiannis, Christopher C, Collyer, Taya A, Arima, Hisatomi, McClure, Leslie A, Chalmers, John, Anderson, Craig S, Benavente, Oscar R, White, Carole L, Algra, Ale, Moran, Chris, Phan, Thanh G, Wang, Wei C, Srikanth, Velandai

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Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials pa... von Moullaali, Tom J, Wang, Xia, Woodhouse, Lisa J, Law, Zhe Kang, Delcourt, Candice, Sprigg, Nikola, Krishnan, Kailash, Robinson, Thompson G, Wardlaw, Joanna M, Al-Shahi Salman, Rustam, Berge, Eivind, Sandset, Else C, Anderson, Craig S, Bath, Philip M, Qureshi, Adnan I, Palesch, Yuko, Potter, John, Wardlaw, Joanna M, Saver, Jeff, Sanossian, Nerses, Butcher, Ken, Lees, Kennedy R, Muir, Keith W, Arima, Hisatomi, Ford, Gary, Horn, Janneke

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A case of esophageal variceal rupture following acute portal vein thrombosis three days after living-related liver transplantation von Hirata, M, Harihara, Y, Hisatomi, S, Miura, Y, Yoshino, H, Mizuta, K, Ito, M, Sano, K, Taniai, N, Kusaka, K, Kita, Y, Kawarasaki, H, Kubota, K, Takayama, T, Makuuchi, M

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The influence of donor age to graft volume increase rate in living donor liver transplantation von Hirata, M, Harihara, Y, Kitamura, T, Hisatomi, S, Kato, M, Dowaki, S, Mizuta, K, Sugawara, Y, Kita, Y, Kubota, K, Takayama, T, Kawarasaki, H, Hashizume, K, Makuuchi, M

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NIHSS cut point for predicting outcome in supra- vs infratentorial acute ischemic stroke von Yoshimura, Sohei, Lindley, Richard I, Carcel, Cheryl, Sato, Shoichiro, Delcourt, Candice, Wang, Xia, Chalmers, John, Anderson, Craig S

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Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men von Syaifullah, Ali Haidar, Shiino, Akihiko, Fujiyoshi, Akira, Kadota, Aya, Kondo, Keiko, Ito, Takahiro, Segawa, Hiroyoshi, Moniruzzaman, Mohammad, Waki, Takashi, Miyagawa, Naoko, Tooyama, Ikuo, Ueshima, Hirotsugu, Miura, Katsuyuki, Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakagawa, Yoshihisa, Yamamoto, Takashi, Nakano, Yasutaka, Ogawa, Emiko, Maegawa, Hiroshi, Morino, Katsutaro, Miyazawa, Itsuko, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Tooyama, Ikuo, Shiino, Akihiko, Andoh, Akira, Tsuru, Teruhiko, Ogita, Hisakazu, Miyamatsu, Naomi, Nakamura, Yasuyuki, Kadota, Aya, Kondo, Keiko, Torii, Sayuki, Kadowaki, Takashi, Kadowaki, Sayaka, Suzuki, Sentaro, Ito, Takahiro, Kunimura, Ayako, Segawa, Hiroyoshi, Fujiyoshi, Akira, Higashiyama, Aya, Okamura, Tomonori, Azuma, Koichiro, Sawamura, Tatsuya, Igase, Michiya, Tabara, Yasuharu, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Murakami, Yoshitaka, Okuda, Nagako, Arima, Hisatomi, Satoh, Atsushi, Kita, Yoshikuni, Hisamatsu, Takashi, Yanagita, Masahiko, Abbott, Robert D., Ohno, Seiko, Takashima, Naoyuki, Miyagawa, Naoko, Zaid, Maryam, Saito, Yoshino

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Ability of self-reported estimates of dietary sodium, potassium and protein to detect an association with general and abdominal obesity: comparison with the estimates derived from... von Murakami, Kentaro, Livingstone, M. Barbara E., Sasaki, Satoshi, Uenishi, Kazuhiro

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Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation von Harihara, Y, Sano, K, Makuuchi, M, Kawarasaki, H, Takayama, T, Kubota, K, Ito, M, Mizuta, K, Yoshino, H, Hirata, M, Kita, Y, Hisatomi, S, Kusaka, K, Miura, Y, Hashizume, K

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Role of natural killer cells in allograft rejection von Guo, L, Harihara, Y, Hirata, M, Kita, Y, Sano, K, Kusaka, K, Hisatomi, S, Miura, Y, Makuuchi, M

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Influence of HLA compatibility on living-related liver transplantation von Harihara, Y, Makuuchi, M, Kawasaki, S, Hashikura, Y, Kawarasaki, H, Takayama, T, Kubota, K, Ito, M, Mizuta, K, Yoshino, H, Hirata, M, Kita, Y, Sano, K, Hisatomi, S, Kusaka, K, Hashizume, K

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Impact of HLA matching in living-related liver transplantation von Hirata, M, Harihara, Y, Kita, Y, Hisatomi, S, Miura, Y, Yoshino, H, Mizuta, K, Ito, M, Sano, K, Kusaka, K, Kawarasaki, H, Kubota, K, Takayama, T, Hashizume, K, Makuuchi, M

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