Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial von Yamada, Yuichiro, Katagiri, Hideki, Hamamoto, Yoshiyuki, Deenadayalan, Srikanth, Navarria, Andrea, Nishijima, Keiji, Seino, Yutaka, Fukushima, Y, Hamamoto, Y, Hisatomi, A, Ide, Y, Inoue, S, Kawada, T, Kim, H, Kiyosue, A, Matoba, K, Matsuoka, O, Nishimura, H, Noguchi, M, Osonoi, T, Sawada, S, Shibasaki, Y, Shin, K, Yamada, Y

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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies von Kaptoge, Stephen, Butterworth, Adam S, Willeit, Peter, Bolton, Thomas, Paige, Ellie, Paul, Dirk S, Bell, Steven, Astle, William, Verschuren, W M Monique, Sato, Shinichi, Njølstad, Inger, Salomaa, Veikko, Yeap, Bu B, Melander, Olle, Marmot, Michael, Dahm, Christina C, Dale, Caroline E, van der Schouw, Yvonne T, Simons, Leon A, Schoufour, Josje D, Key, Timothy J, Moreno-Iribas, Conchi, Davidson, Karina W, Taylor, James O, Wallace, Robert B, Tumino, Rosario, Linneberg, Allan, Panico, Salvatore, Nietert, Paul J, Kromhout, Daan, Kiechl, Stefan, Palli, Domenico, Huerta, José M, Karakatsani, Anna, Kühn, Tilman, Grobbee, Diederick E, Kauhanen, Jussi, Wennberg, Maria, Cushman, Mary, Cooper, Jackie A, Rodriguez, Carlos J, Shaw, Jonathan E, Voortman, Trudy, Dallongeville, Jean, Brunner, Eric J, Lazo, Mariana, Leon, David A, Smith, George Davey, Peto, Richard, Jackson, Rod, Banks, Emily, Butterworth, Adam, Warnakula, Samantha, Paige, Ellie, Bell, Steven, Astle, William, Sato, Shinichi, Veikko, Salomaa, Flecther, Astrid, Melander, Olle, Kuller, Lewis H, Koenig, Wolfgang, Casiglia, Edoardo, Arndt, Volker, Völzke, Henry, Dahm, Christina C, Dale, Caroline E, Bergmann, Manuela, Crespo, Carlos, Kaaks, Rudolf, Simons, Leon A, Lagiou, Pagona, Key, Timothy J, Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W, Quiros, J. Ramon, Skeie, Guri, Salomaa, Veikko, Strandberg, Timo, Nietert, Paul J, Salamanca-Fernandez, Elena, Krumholz, Harlan M, Price, Jackie, Travis, Ruth C, Kühn, Tilman, Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Forouhi, Nita, Wennberg, Maria, Brenner, Hermann, Assmann, Gerd, Trevisan, Maurizio, Gillumn, Richard F, Thompson, Simon, Ferrari, Pietro, Davey Smith, George

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Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial von Zinman, Bernard, Aroda, Vanita R, Buse, John B, Cariou, Bertrand, Harris, Stewart B, Hoff, Søren Tetens, Pedersen, Karen Boje, Tarp-Johansen, Mads Jeppe, Araki, Eiichi

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Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3... von Anderson, Craig S, Arima, Hisatomi, Chen, Guofang, Martins, Sheila O, Silva, Federico, Thang, Nguyen H, Arima, Hisatomi, Li, Qiang, Martins, Sheila O., Pontes-Neto, Octavio M., Wang, Xia, Simes, R. John, Hirakawa, Yoichiro, Moullaali, Tom J., Carcel, Cheryl, Gordon, Penny, Cao, Yongjun, Winters, Stephen, Zhang, Shihong, Manning, Lisa, Minhas, Jatinder, Malavera, Alejandra, Ivanova, Elizaveta, Armenis, Manuela, Blacklock, Nick, Naidu, Bala, Smith, Phillipa, Kong, Liang, Ebraimo, Ahtasam, Phuong, Do M., Tran, Nguyen T.B., Hoa, Nguyen A., Ray, E., Ng, G., Weiss, G., Titton, N., Castro, R., Fagundes, D., Alves, M., Rivas, R., Herrera, A., Zhou, S., Ping, L., Shi, J., Gong, P., Zhao, H., Li, R., Liu, D., Liang, L., Xia, J., Zhao, N., Huang, W., Zhang, A., Liu, H., Zhang, Y., Li, F., Huang, L., Zheng, R., Liu, J., Zhang, S., Liu, X., Lai, Y., Du, J., Wei, C., Li, W, Zeng, X., Wu, X., Castellanos, J.A., Raj, P.G., Parmar, M., Patel, D., Gorthi, S.P., Prabhu, A., Nair, R., TP, S., Choudhury, N., Duberkar, D., Sacchini, E., Padiglioni, C., Kim, J., Hwang, H.W., Kwon, S.U., Kim, Y.J., Kim, B., Kim, Y.W., Lee, J.J., Chang, H.M., Martínez, A., Lin, Y.J., Huang, Y.C., Dyker, A., Natarajan, I., Qadiri, M.R., Smith, C., James, M., Marsden, T., Price, C., Bergin, A., Le Kim, K., Le Thanh, T. Tran

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Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis von Grams, Morgan E, Coresh, Josef, Matsushita, Kunihiro, Ballew, Shoshana H, Sang, Yingying, Surapaneni, Aditya, Alencar de Pinho, Natalia, Anderson, Amanda, Appel, Lawrence J, Ärnlöv, Johan, Azizi, Fereidoun, Bansal, Nisha, Bell, Samira, Bilo, Henk J G, Brunskill, Nigel J, Carrero, Juan J, Chadban, Steve, Chalmers, John, Chen, Jing, Ciemins, Elizabeth, Cirillo, Massimo, Ebert, Natalie, Evans, Marie, Ferreiro, Alejandro, Fu, Edouard L, Fukagawa, Masafumi, Green, Jamie A, Gutierrez, Orlando M, Herrington, William G, Hwang, Shih-Jen, Inker, Lesley A, Iseki, Kunitoshi, Jafar, Tazeen, Jassal, Simerjot K, Jha, Vivekanand, Kadota, Aya, Katz, Ronit, Köttgen, Anna, Konta, Tsuneo, Kronenberg, Florian, Lee, Brian J, Lees, Jennifer, Levin, Adeera, Looker, Helen C, Major, Rupert, Melzer Cohen, Cheli, Mieno, Makiko, Miyazaki, Mariko, Moranne, Olivier, Muraki, Isao, Naimark, David, Nitsch, Dorothea, Oh, Wonsuk, Pena, Michelle, Purnell, Tanjala S, Sabanayagam, Charumathi, Satoh, Michihiro, Sawhney, Simon, Schaeffner, Elke, Schöttker, Ben, Shen, Jenny I, Shlipak, Michael G, Sinha, Smeeta, Stengel, Benedicte, Sumida, Keiichi, Tonelli, Marcello, Valdivielso, Jose M, van Zuilen, Arjan D, Visseren, Frank L J, Wang, Angela Yee-Moon, Wen, Chi-Pang, Wheeler, David C, Yatsuya, Hiroshi, Yamagata, Kunihiro, Yang, Jae Won, Young, Ann, Zhang, Haitao, Zhang, Luxia, Levey, Andrew S, Gansevoort, Ron T

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Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium von Chang, Alex R, Grams, Morgan E, Ballew, Shoshana H, Bilo, Henk, Correa, Adolfo, Evans, Marie, Gutierrez, Orlando M, Hosseinpanah, Farhad, Iseki, Kunitoshi, Kenealy, Timothy, Klein, Barbara, Kronenberg, Florian, Lee, Brian J, Li, Yuanying, Miura, Katsuyuki, Navaneethan, Sankar D, Roderick, Paul J, Valdivielso, Jose M, Visseren, Frank L J, Zhang, Luxia, Gansevoort, Ron T, Hallan, Stein I, Levey, Andrew S, Matsushita, Kunihiro, Shalev, Varda, Woodward, Mark

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Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies von Coresh, Josef, Sang, Yingying, Matsushita, Kunihiro, Arnlov, Johan, Black, Corri, Brunskill, Nigel J, Carrero, Juan-Jesus, Feldman, Harold I, Ishani, Areef, Ito, Sadayoshi, Jassal, Simerjot, Polkinghorne, Kevan, Romundstad, Solfrid, Solbu, Marit D, Stempniewicz, Nikita, Tonelli, Marcello, Umesawa, Mitsumasa, Waikar, Sushrut S, Wen, Chi-Pang, Wetzels, Jack F M, Woodward, Mark, Kovesdy, Csaba P, Levey, Andrew S, Greene, Tom, Chen, Teresa K, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Herrington, William G, Smith, Margaret, Hsu, C Yenchih, Chang, Alex R, Green, Jamie A, Ho, Kevin, Marks, Angharad, Prescott, Gordon, Clark, Laura E, Fluck, Nick, Shalev, Varda, Van Zuilen, Arjan, Van den Brand, Jan A, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen G, Nadukuru, Rajiv, Metzger, Marie, Houillier, Pascal, Haymann, Jean-Philippe, Froissart, Marc, Kenealy, Timothy, Elley, Raina C, Collins, John F, Drury, Paul L, Cuddeback, John K, Stempniewicz, Rich, Knowler, William C, Major, Rupert W, Medcalf, James F, Shepherd, David, Barrett-Connor, Elizabeth, Molnar, Miklos Z, Sumida, Keiichi, de Zeeuw, Dick, Qureshi, Abdul R, Elinder, Carl-Gustaf, Runesson, Bjorn, Evans, Marie, Segelmark, Marten, Schön, Staffan, Tangri, Navdeep, Hirayama, Atsushi, Ichikawa, Kazunobu, Bilo, Henk JG, Landman, Gijs WD, Van Hateren, Kornelis JJ, Kleefstra, Nanne, Ballew, Shoshana H, Chen, Jingsha, Rodby, Roger A., Rohde, Richard D, Lewis, Julia B, Lewis, Edmund, Perrone, Ronald D, Abebe, Kaleab Z, Hou, Fan F, Xie, Di, Hunsicker, Lawrence G, Imai, Enyu, Kobayashi, Fumiaki, Makino, Hirofumi, Remuzzi, Giuseppe, Eckardt, Kai-Uwe, Gudmundsdottir, Hrefna, Maciulaitis, Romaldas, Manley, Tom, Stockbridge, Norman, Thompson, Aliza

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Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke von Li, Gang, Lin, Yapeng, Yang, Jie, Anderson, Craig S., Chen, Chen, Liu, Feifeng, Billot, Laurent, Li, Qiang, Chen, Xiaoying, Liu, Xiaoqiu, Ren, Xinwen, Zhang, Chunfang, Xu, Ping, Wu, Lijun, Wang, Feng, Qiu, Daijun, Jiang, Mei, Peng, Yiqian, Li, Chaohui, Huang, Yiyang, Zhao, Xiaohui, Liang, Jiye, Wang, Yao, Wu, Xiangjun, Xu, Xiaoyun, Chen, Guofang, Huang, Dongya, Zhang, Yue, Zuo, Lian, Ma, Guozhao, Yang, Yumei, Hao, Junjie, Xu, Xiahong, Xiong, Xinli, Tang, Yueyu, Guo, Yijia, Yu, Jianping, Li, Shuping, He, Song, Mao, Fengkai, Tan, Quandan, Tan, Song, Yu, Nengwei, Xu, Ruxiang, Sun, Mingwei, Li, Binghu, Guo, Jiang, Liu, Leibo, Liu, Hueiming, Ouyang, Menglu, Si, Lei, Arima, Hisatomi, Bath, Philip M., Ford, Gary A., Robinson, Thompson, Sandset, Else Charlotte, Saver, Jeffrey L., Sprigg, Nikola, van der Worp, H. Bart, Song, Lili

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Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018

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Involvement of the Ets-1 gene in overexpression of matrilysin in human hepatocellular carcinoma von OZAKI, Iwata, MIZUTA, Toshihiko, GANG ZHAO, YOTSUMOTO, Hiroaki, HARA, Toshiya, KAJIHARA, Susumu, HISATOMI, Akitaka, SAKAI, Takahiro, YAMAMOTO, Kyosuke

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Is Blood Pressure Lowering in the Very Elderly With Previous Stroke Associated With a Higher Risk of Adverse Events? von Tharmaratnam, Damien, Karayiannis, Christopher C, Collyer, Taya A, Arima, Hisatomi, McClure, Leslie A, Chalmers, John, Anderson, Craig S, Benavente, Oscar R, White, Carole L, Algra, Ale, Moran, Chris, Phan, Thanh G, Wang, Wei C, Srikanth, Velandai

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Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials pa... von Moullaali, Tom J, Wang, Xia, Woodhouse, Lisa J, Law, Zhe Kang, Delcourt, Candice, Sprigg, Nikola, Krishnan, Kailash, Robinson, Thompson G, Wardlaw, Joanna M, Al-Shahi Salman, Rustam, Berge, Eivind, Sandset, Else C, Anderson, Craig S, Bath, Philip M

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NIHSS cut point for predicting outcome in supra- vs infratentorial acute ischemic stroke von Yoshimura, Sohei, Lindley, Richard I, Carcel, Cheryl, Sato, Shoichiro, Delcourt, Candice, Wang, Xia, Chalmers, John, Anderson, Craig S

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[360] INHIBITION OF MULTIPLE MATRIX METALLOPROTEINASE EXPRESSION BY VITAMIN K2 THROUGH PROTEIN KINASE C PATHWAY IN HUMAN HEPATOCELLULAR CARCINOMA CELLS von Ide, Y, Zhang, H, Mizuta, T, Eguchi, Y, Yasutake, T, Hisatomi, A, Ozaki, I

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Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men von Syaifullah, Ali Haidar, Shiino, Akihiko, Fujiyoshi, Akira, Kadota, Aya, Kondo, Keiko, Ito, Takahiro, Segawa, Hiroyoshi, Moniruzzaman, Mohammad, Waki, Takashi, Miyagawa, Naoko, Tooyama, Ikuo, Ueshima, Hirotsugu, Miura, Katsuyuki, Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakagawa, Yoshihisa, Yamamoto, Takashi, Nakano, Yasutaka, Ogawa, Emiko, Maegawa, Hiroshi, Morino, Katsutaro, Miyazawa, Itsuko, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Tooyama, Ikuo, Shiino, Akihiko, Andoh, Akira, Tsuru, Teruhiko, Ogita, Hisakazu, Miyamatsu, Naomi, Nakamura, Yasuyuki, Kadota, Aya, Kondo, Keiko, Torii, Sayuki, Kadowaki, Takashi, Kadowaki, Sayaka, Suzuki, Sentaro, Ito, Takahiro, Kunimura, Ayako, Segawa, Hiroyoshi, Fujiyoshi, Akira, Higashiyama, Aya, Okamura, Tomonori, Azuma, Koichiro, Sawamura, Tatsuya, Igase, Michiya, Tabara, Yasuharu, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Murakami, Yoshitaka, Okuda, Nagako, Arima, Hisatomi, Satoh, Atsushi, Kita, Yoshikuni, Hisamatsu, Takashi, Yanagita, Masahiko, Abbott, Robert D., Ohno, Seiko, Takashima, Naoyuki, Miyagawa, Naoko, Zaid, Maryam, Saito, Yoshino

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Ability of self-reported estimates of dietary sodium, potassium and protein to detect an association with general and abdominal obesity: comparison with the estimates derived from... von Murakami, Kentaro, Livingstone, M. Barbara E., Sasaki, Satoshi, Uenishi, Kazuhiro

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Head Position in Stroke Trial (HeadPoST)--sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial von Muñoz-Venturelli, Paula, Arima, Hisatomi, Lavados, Pablo, Brunser, Alejandro, Peng, Bin, Cui, Liying, Song, Lily, Billot, Laurent, Boaden, Elizabeth, Hackett, Maree L, Heritier, Stephane, Jan, Stephen, Middleton, Sandy, Olavarría, Verónica V, Lim, Joyce Y, Lindley, Richard I, Heeley, Emma, Robinson, Thompson, Pontes-Neto, Octavio, Natsagdorj, Lkhamtsoo, Lin, Ruey-Tay, Watkins, Caroline, Anderson, Craig S

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Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?: A Randomized Controlled Trial von Matsumura, Kiyoshi, Arima, Hisatomi, Tominaga, Mitsuhiro, Ohtsubo, Toshio, Sasaguri, Toshiyuki, Fujii, Koji, Fukuhara, Masayo, Uezono, Keiko, Morinaga, Yuki, Ohta, Yuko, Otonari, Takatoshi, Kawasaki, Junya, Kato, Isao, Tsuchihashi, Takuya, Investigators, for the COMFORT

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Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification von Zaid, Maryam, MSc, Miura, Katsuyuki, MD, PhD, Fujiyoshi, Akira, MD, PhD, Abbott, Robert D., PhD, Hisamatsu, Takashi, MD, PhD, Kadota, Aya, MD, PhD, Arima, Hisatomi, MD, PhD, Kadowaki, Sayaka, MD, PhD, Torii, Sayuki, MD, PhD, Miyagawa, Naoko, PhD, RD, Suzuki, Sentaro, MD, Takashima, Naoyuki, MD, PhD, Ohkubo, Takayoshi, MD, PhD, Sekikawa, Akira, MD, PhD, PhD, Maegawa, Hiroshi, MD, PhD, Horie, Minoru, MD, PhD, Nakamura, Yasuyuki, MD, PhD, Okamura, Tomonori, MD, PhD, Ueshima, Hirotsugu, MD, PhD

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Serum adiponectin concentration in relation to macronutrient and food intake in young Japanese women von Murakami, Kentaro, Ph.D, Sasaki, Satoshi, M.D., Ph.D, Uenishi, Kazuhiro, Ph.D

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