Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma von Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

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ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model von Iwaki, Yuzo, Ohhata, Akira, Nakatani, Shingo, Hisaichi, Katsuya, Okabe, Yasuyuki, Hiramatsu, Atsushi, Watanabe, Toshihide, Yamamoto, Shingo, Nishiyama, Taihei, Kobayashi, Juta, Hirooka, Yasuo, Moriguchi, Hideki, Maeda, Tatsuo, Katoh, Makoto, Komichi, Yuka, Ota, Hiroto, Matsumura, Naoya, Okada, Masahiro, Sugiyama, Tetsuya, Saga, Hiroshi, Imagawa, Akira

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Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines von Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Odagaki, Yshihiko, Nakai, Hisao, Toda, Masaaki

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Discovery of Gemilukast (ONO-6950), a Dual CysLT 1 and CysLT 2 Antagonist As a Therapeutic Agent for Asthma von Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

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Discovery of orally available spirodiketopiperazine-based CCR5 antagonists von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Hirai, Keisuke, Habashita, Hiromu, Takaoka, Yoshikazu, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Maeda, Kenji, Mitsuya, Hiroaki, Nakai, Hisao, Fukushima, Daikichi, Toda, Masaaki

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Discovery of 4-[4-({(3 R)-1-butyl-3-[( R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally av... von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Minamoto, Chiaki, Murota, Masayuki, Takaoka, Yoshikazu, Nakai, Hisao, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki

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Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Hirai, Keisuke, Habashita, Hiromu, Takaoka, Yoshikazu, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Maeda, Kenji, Mitsuya, Hiroaki, Nakai, Hisao, Fukushima, Daikichi, Toda, Masaaki

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Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Matsunaga, Naoki, Minamoto, Chiaki, Habashita, Hiromu, Takaoka, Yoshikazu, Toda, Masaaki, Shibayama, Shiro, Tada, Hideaki, Sagawa, Kenji, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki

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Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Minamoto, Chiaki, Matsunaga, Naoki, Takaoka, Yoshikazu, Nakai, Hisao, Jenkinson, Stephen, Kazmierski, Wieslaw M., Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki

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Discovery of 4-4-({(3R)-1-butyl-3-(R)-cyclohexyl(hydroxy)methyl-2,5-dioxo-1,4,9-triazaspiro5.5undec-9-yl}methyl)phenoxybenzoic acid hydrochloride: a highly potent orally available... von Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Minamoto, Chiaki, Murota, Masayuki, Takaoka, Yoshikazu, Nakai, Hisao, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki

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STABLE CRYSTAL OF TRICYCLIC SPIRO COMPOUND von HISAICHI KATSUYA

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Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability von Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki

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Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro... von KAWANAKA, Yasufumi, KOBAYASHI, Kaoru, NAKA, Masao, KOMENO, Masaharu, NAKAI, Hisao, TODA, Masaaki, KUSUDA, Shinya, TATSUMI, Tadashi, MUROTA, Masayuki, NISHIYAMA, Toshihiko, HISAICHI, Katsuya, FUJII, Atsuko, HIRAI, Keisuke, NISHIZAKI, Minoru

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Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines von Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masanori, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki

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Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1 H)-imines and 1,5,6,7-Tetrahydr... von Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Nishizaki, Minoru, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki

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Molecular design and synthesis of a biscalix[4]arene-based cage molecule von Araki, Koji, Sisido, Koichi, Hisaichi, Katsuya, Shinkai, Seiji

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One Step Synthesis of Dihydropyridin-2-imines: Inhibitors of Inducible Nitric Oxide Synthase von Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masanori, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki

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METHOD FOR PRODUCING beta-HYDROXYAMINO ACID DERIVATIVE AND INTERMEDIATE OF THE SAME von HISAICHI KATSUYA, TAKAOKA YOSHIKAZU, MATSUNAGA NAOKI

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Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof von TANAKA MAKOTO, HISAICHI KATSUYA, HATAYAMA AKIRA, OHMOTO KAZUYUKI, YAMADA HIROYUKI

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Nitriles and medicinal compositions containing the same as the active ingredient von TANAKA MAKOTO, HISAICHI KATSUYA, KAWADA NAOKI, OKUMA MOTOHIRO, OHMOTO KAZUYUKI

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