Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma von SHAKYA, Reena, GONDA, Tamas, WANG, Timothy C, SZABOLCS, Matthias, TYCKO, Benjamin, LUDWIG, Thomas, QUANTE, Michael, SALAS, Martha, KIM, Samuel, BROOKS, Jenna, HIRSCH, Steffen, DAVIES, Justine, CULLO, Angelica, OLIVE, Kenneth

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BRCA1/2 potential founder variants in the Jordanian population: an opportunity for a customized screening panel von Ahmad, Olfat, Sutter, Christian, Hirsch, Steffen, Pfister, Stefan M, Schaaf, Christian P

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High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience von Carceller, Fernando, Hirsch, Steffen G., Khabra, Komel, Petterson, Toni, Malik, Rubina, Guerra-García, Pilar, Moreno, Lucas, Marshall, Lynley V., Taj, Mary, Atra, Ayad, Ethell, Mark, Potter, Mike, Lancaster, Donna

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NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology von Mock, Andreas, Teleanu, Maria-Veronica, Kreutzfeldt, Simon, Heilig, Christoph E., Hüllein, Jennifer, Möhrmann, Lino, Jahn, Arne, Hanf, Dorothea, Kerle, Irina A., Singh, Hans Martin, Hutter, Barbara, Uhrig, Sebastian, Fröhlich, Martina, Neumann, Olaf, Hartig, Andreas, Brückmann, Sascha, Hirsch, Steffen, Grund, Kerstin, Dikow, Nicola, Lipka, Daniel B., Renner, Marcus, Bhatti, Irfan Ahmed, Apostolidis, Leonidas, Schlenk, Richard F., Schaaf, Christian P., Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Heining, Christoph, Horak, Peter, Glimm, Hanno, Fröhling, Stefan

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The impact of methylome analysis on the diagnosis and treatment of CNS tumours in children and adolescents: A population-based study in Greece von Filippidou, Maria, Glentis, Stavros, Binenbaum, Ilona, Sill, Martin, Roka, Kleoniki, Vlachou, Antonia, Avgerinou, Georgia, Ecker, Jonas, Selt, Florian, Hasselblatt, Martin, Blattner-Johnson, Mirjam, Schramm, Kathrin, Trougkou, Clio, Doganis, Dimitrios, Katzilakis, Nikolaos, Ridola, Vita, Papakonstantinou, Evgenia, Papadakis, Vassilios, Hatzipantelis, Emmanouel, Kokkinou, Eleftheria, Pons, Roser, Kanaka-Gantenbein, Christina, Sturm, Dominik, Hirsch, Steffen, Dikow, Nicola, Pajtler, Kristian W., van Tilburg, Cornelis M., Frühwald, Michael C., Milde, Till, Witt, Olaf, Jones, David T.W., Von Deimling, Andreas, Sahm, Felix, Stefanaki, Kalliopi, Pfister, Stefan M., Kattamis, Antonis

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Germline testing for homologous recombination repair genes—opportunities and challenges von Hirsch, Steffen, Gieldon, Laura, Sutter, Christian, Dikow, Nicola, Schaaf, Christian P.

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The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets von van Tilburg, Cornelis M, Pfaff, Elke, Pajtler, Kristian W, Langenberg, Karin P S, Fiesel, Petra, Jones, Barbara C, Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D, Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E, Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M, von Bueren, André O, Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C, Schneider, Dominik T, Brecht, Ines B, Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T, Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U, Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T W, Molenaar, Jan J, Capper, David, Pfister, Stefan M, Witt, Olaf

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Hao-Fountain syndrome: 32 novel patients reveal new insights into the clinical spectrum von Wimmer, Moritz Claudius, Brennenstuhl, Heiko, Hirsch, Steffen, Dötsch, Laura, Unser, Samy, Caro, Pilar, Schaaf, Christian Patrick

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Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology von Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., Jones, David. T. W.

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BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity von Shakya, Reena, Reid, Latarsha J., Reczek, Colleen R., Cole, Francesca, Egli, Dieter, Lin, Chyuan-Sheng, deRooij, Dirk G., Hirsch, Steffen, Ravi, Kandasamy, Hicks, James B., Szabolcs, Matthias, Jasin, Maria, Baer, Richard, Ludwig, Thomas

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Molecular analysis of cancer genomes in children with Lynch syndrome: Exploring causal associations von Weijers, Dilys D, Hirsch, Steffen, Bakhuizen, Jette J, van Engelen, Nienke, Kester, Lennart A, Kranendonk, Mariëtte E.G, Hiemcke-Jiwa, Laura S, de Vos-Kerkhof, Evelien, Loeffen, Jan L.C, Autry, Robert J, Pajtler, Kristian W, Jäger, Natalie, Jongmans, Marjolijn C.J, Kuiper, Roland P

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Chromothripsis in Human Breast Cancer von Bolkestein, Michiel, Wong, John K L, Thewes, Verena, Körber, Verena, Hlevnjak, Mario, Elgaafary, Shaymaa, Schulze, Markus, Kommoss, Felix K F, Sinn, Hans-Peter, Anzeneder, Tobias, Hirsch, Steffen, Devens, Frauke, Schröter, Petra, Höfer, Thomas, Schneeweiss, Andreas, Lichter, Peter, Zapatka, Marc, Ernst, Aurélie

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Benchmarking whole exome sequencing in the German network for personalized medicine von Menzel, Michael, Goldschmid, Hannah, Romanovsky, Eva, Siemanowski-Hrach, Janna, Seillier, Lancelot, Maurer, Angela, Begemann, Matthias, Elbracht, Miriam, Meyer, Robert, Dintner, Sebastian, Claus, Rainer, Meier-Kolthoff, Jan P., Blanc, Eric, Möbs, Markus, Joosten, Maria, Benary, Manuela, Basitta, Patrick, Tischler, Verena, Groß, Thomas, Kutz, Oliver, Prause, Rebecca, William, Doreen, Horny, Kai, Goering, Wolfgang, Sivalingam, Sugirthan, Borkhardt, Arndt, Blank, Cornelia, Junk, Stefanie V., Yasin, Layal, Moskalev, Evgeny A., Ferrazzi, Fulvia, Tögel, Lars, Wolter, Steffen, Adam, Eugen, Matysiak, Uta, Rosenthal, Tessa, Lehmann, Ulrich, Schmidt, Gunnar, Bartels, Stephan, Hirsch, Steffen, Dikow, Nicola, Göbel, Kirsten, Banan, Rouzbeh, Hamelmann, Stefan, Fink, Annette, Ball, Markus, Neumann, Olaf, Rehker, Jan, Kloth, Michael, Murtagh, Justin, Hartmann, Nils, Jurmeister, Phillip, Mock, Andreas, Kumbrink, Jörg, Jung, Andreas, Mayr, Eva-Maria, Jacob, Anne, Trautmann, Marcel, Kirmse, Santina, Falkenberg, Kim, Ruckert, Christian, Hirsch, Daniela, Immel, Alexander, Dietmaier, Wolfgang, Haack, Tobias, Marienfeld, Ralf, Fürstberger, Axel, Niewöhner, Jakob, Gerstenmaier, Uwe, Eberhardt, Timo, Greif, Philipp A., Appenzeller, Silke, Doll, Julia, Jelting, Yvonne, Märkl, Bruno, Horst, David, Wulf, Anna-Lena, Aust, Daniela, Werner, Martin, Reuter-Jessen, Kirsten, Ströbel, Philipp, Auber, Bernd, Sahm, Felix, Merkelbach-Bruse, Sabine, Siebolts, Udo, Roth, Wilfried, Lassmann, Silke, Klauschen, Frederick, Gaisa, Nadine T., Evert, Matthias, Armeanu-Ebinger, Sorin, Ossowski, Stephan, Schroeder, Christopher, Schaaf, Christian P., Malek, Nisar, Schirmacher, Peter, Kazdal, Daniel, Pfarr, Nicole, Budczies, Jan, Stenzinger, Albrecht

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HGG-23. DECIPHERING THE RELATIONSHIP OF MICROSATELLITE-INSTABILITY AND MUTATIONAL BURDEN IN HIGH-GRADE GLIOMA PATIENTS WITH CONSTITUTIONALLY IMPAIRED DNA DAMAGE RESPONSE von Blattner-Johnson, Mirjam, Sturm, Dominik, Jones, Barbara C, Previti, Christopher, Sievers, Philipp, Jäger, Natalie, Hirsch, Steffen, Dikow, Nicola, Sahm, Felix, Kramm, Christof M, Witt, Olaf, Pfister, Stefan M, Jones, David T W

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Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry von Ecker, Jonas, Selt, Florian, Sturm, Dominik, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David, Dikow, Nicola, Sutter, Christian, Müller, Carina, Sigaud, Romain, Eggert, Angelika, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T.W., Sahm, Felix, Pfister, Stefan M., Witt, Olaf, Milde, Till

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Corrigendum to ‘Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry’ [Eur J Cancer 180 (2023) 71–84] von Ecker, Jonas, Selt, Florian, Sturm, Dominik, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David, Dikow, Nicola, Sutter, Christian, Müller, Carina, Sigaud, Romain, Eggert, Angelika, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T.W., Sahm, Felix, Pfister, Stefan M., Witt, Olaf, Milde, Till

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Molecular analysis of cancer genomes in children with Lynch syndrome: Exploring causal associations von Weijers, Dilys D., Hirsch, Steffen, Bakhuizen, Jette J., Engelen, Nienke, Kester, Lennart A., Kranendonk, Mariëtte E. G., Hiemcke‐Jiwa, Laura S., Vos‐Kerkhof, Evelien, Loeffen, Jan L. C., Autry, Robert J., Pajtler, Kristian W., Jäger, Natalie, Jongmans, Marjolijn C. J., Kuiper, Roland P.

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HGG-21. DISTRIBUTION AND MUTATIONAL PATTERNS OF TP53 ALTERATIONS ACROSS SUBTYPES OF PEDIATRIC HIGH-GRADE GLIOMAS von Blattner-Johnson, Mirjam, Sturm, Dominik, Hirsch, Steffen, Jones, Barbara, Schramm, Kathrin, Balasubramanian, Gnana Prakash, Sill, Martin, Autry, Robert, Previti, Christopher, van Tilburg, Cornelis M, Milde, Till, Pajtler, Kristian W, Sahm, Felix, Kramm, Christof M, Witt, Olaf, Pfister, Stefan M, Jones, David T W

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Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology von Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K, Ebrahimi, Azadeh, Suwala, Abigail K, Gielen, Gerrit H, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C, Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Gerber, Nicolas U

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Hemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual di... von Liu, Zhigang, Xin, Baozhong, Smith, Iris N, Sency, Valerie, Szekely, Julia, Alkelai, Anna, Shuldiner, Alan, Efthymiou, Stephanie, Rajabi, Farrah, Coury, Stephanie, Brownstein, Catherine A, Rudnik-Schöneborn, Sabine, Bruel, Ange-Line, Thevenon, Julien, Zeidler, Shimriet, Jayakar, Parul, Schmidt, Axel, Cremer, Kirsten, Engels, Hartmut, Peters, Sophia O, Zaki, Maha S, Duan, Ruizhi, Zhu, Changlian, Xu, Yiran, Gao, Chao, Sepulveda-Morales, Tania, Maroofian, Reza, Alkhawaja, Issam A, Khawaja, Mariam, Alhalasah, Hunaida, Houlden, Henry, Madden, Jill A, Turchetti, Valentina, Marafi, Dana, Agrawal, Pankaj B, Schatz, Ulrich, Rotenberg, Ari, Rotenberg, Joshua, Mancini, Grazia M S, Bakhtiari, Somayeh, Kruer, Michael, Thiffault, Isabelle, Hirsch, Steffen, Hempel, Maja, Stühn, Lara G, Haack, Tobias B, Posey, Jennifer E, Lupski, James R, Lee, Hyunpil, Sarn, Nicholas B, Eng, Charis, Gonzaga-Jauregui, Claudia, Zhang, Bin, Wang, Heng

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