Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423 von Kashiyama, Tomoko, Oda, Katsutoshi, Ikeda, Yuji, Shiose, Yoshinobu, Hirota, Yasuhide, Inaba, Kanako, Makii, Chinami, Kurikawa, Reiko, Miyasaka, Aki, Koso, Takahiro, Fukuda, Tomohiko, Tanikawa, Michihiro, Shoji, Keiko, Sone, Kenbun, Arimoto, Takahide, Wada-Hiraike, Osamu, Kawana, Kei, Nakagawa, Shunsuke, Matsuda, Koichi, McCormick, Frank, Aburatani, Hiroyuki, Yano, Tetsu, Osuga, Yutaka, Fujii, Tomoyuki

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Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity von Kawai, Junya, Toki, Tadashi, Ota, Masahiro, Inoue, Hidekazu, Takata, Yoshimi, Asahi, Takashi, Suzuki, Makoto, Shimada, Takashi, Ono, Kaori, Suzuki, Kanae, Takaishi, Sachiko, Ohki, Hitoshi, Matsui, Satoshi, Tsutsumi, Shinji, Hirota, Yasuhide, Nakayama, Kiyoshi

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Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion von Yoshihama, Yohei, Namiki, Hidenori, Kato, Taiga, Shimazaki, Naomi, Takaishi, Sachiko, Kadoshima-Yamaoka, Kumiko, Yukinaga, Hideo, Maeda, Naoyuki, Shibutani, Tomoko, Fujimoto, Kazunori, Hirasawa, Makoto, Goto, Hiroki, Wada, Naoya, Tsutsumi, Shinji, Hirota, Yasuhide, Ishikawa, Tomoki, Yamamoto, Shoji

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A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo von Mitsui, Ikuo, Kumazawa, Eiji, Hirota, Yasuhide, Aonuma, Masashi, Sugimori, Masamichi, Ohsuki, Satoru, Uoto, Kouichi, Ejima, Akio, Terasawa, Hirofumi, Sato, Keiki

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Human Telomerase Exists in Two Distinct Active Complexes In Vivo von Mizuno, Hideki, Khurts, Shilagardi, Seki, Takahiko, Hirota, Yasuhide, Kaneko, Shuichi, Murakami, Seishi

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Synthesis and Structure-Activity Relationships of Novel 2', 2'-Difluoro Analogues of Docetaxel von UOTO, Kouichi, OHSUKI, Satoru, TAKENOSHITA, Haruhiro, ISHIYAMA, Takashi, IIMURA, Shin, HIROTA, Yasuhide, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko

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Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma von Koul, Dimpy, Wang, Shuzhen, Wu, Shaofang, Saito, Norihiko, Zheng, Siyuan, Gao, Feng, Kaul, Isha, Setoguchi, Masaki, Nakayama, Kiyoshi, Koyama, Kumiko, Shiose, Yoshinobu, Sulman, Erik P, Hirota, Yasuhide, Yung, W K Alfred

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p53 Antisense Oligonucleotide Inhibits Growth of Human Colon Tumor and Normal Cell Lines von Hirota, Yasuhide, Horiuchi, Tadashi, Akahane, Kouichi

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ATPS-46PRECLINICAL THERAPEUTIC EFFICACY OF A NOVEL BLOOD-BRAIN BARRIER-PENETRANT DUAL PI3K/MTOR INHIBITOR WITH PREFERENTIAL RESPONSE IN PI3K/PTEN MUTANT GLIOMA von Koul, Dimpy, Wang, Shuzhen, Saito, Norihiko, Zheng, Siyuan, Wu, Shaofang, Setoguchi, Masaki, Nakayama, Kiyoshi, Koyama, Kumiko, Shiose, Yoshinobu, Sulman, Erik P., Hirota, Yasuhide, Yung, W. K. Alfred

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Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11 von Kawato, Y, Aonuma, M, Hirota, Y, Kuga, H, Sato, K

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Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase von Hirota, Y, Lahti, J M

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Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogs of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position von UOTO, Kouichi, TAKENOSHITA, Haruhiro, YOSHINO, Toshiharu, HIROTA, Yasuhide, ANDO, Shuichi, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko

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Deoxyribonucleoside-triphosphate imbalance death: Deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death von Yoshioka, Akiko, Tanaka, Shohei, Hiraoka, Osamu, Koyama, Yuji, Hirota, Yasuhide, Wataya, Yusuke

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Double-stranded polynucleotide von Koizumi Makoto, Hirota Yasuhide

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DOUBLE-STRANDED POLYNUCLEOTIDE von HIROTA, YASUHIDE, KOIZUMI, MAKOTO

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Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues von Sugimori, Masamichi, Ejima, Akio, Ohsuki, Satoru, Uoto, Kouichi, Mitsui, Ikuo, Kawato, Yasuyoshi, Hirota, Yasuhide, Sato, Keiki, Terasawa, Hirofumi

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MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE von HIROTA, YASUHIDE, KOIZUMI, MAKOTO

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polinucleotídeo ou um sal deste, composição farmacêutica, uso de um polinucleotídeo ou um sal deste, reagente, composição, e, método para produzir um composto von MAKIKO NAKAYAMA, MAKOTO KOIZUMI, MIKA IKEDA, YASUHIDE HIROTA

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Double-stranded polynucleotide von HIROTA, YASUHIDE, KOIZUMI, MAKOTO

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DOUBLE-STRANDED POLYNUCLEOTIDE von HIROTA, YASUHIDE, KOIZUMI, MAKOTO

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