Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants von Ku, Zhiqiang, Xie, Xuping, Hinton, Paul R., Liu, Xinli, Ye, Xiaohua, Muruato, Antonio E., Ng, Dean C., Biswas, Sujit, Zou, Jing, Liu, Yang, Pandya, Deepal, Menachery, Vineet D., Rahman, Sachi, Cao, Yu-An, Deng, Hui, Xiong, Wei, Carlin, Kevin B., Liu, Junquan, Su, Hang, Haanes, Elizabeth J., Keyt, Bruce A., Zhang, Ningyan, Carroll, Stephen F., Shi, Pei-Yong, An, Zhiqiang

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An Engineered Human IgG1 Antibody with Longer Serum Half-Life von Hinton, Paul R, Xiong, Joanna M, Johlfs, Mary G, Tang, Meina Tao, Keller, Stephen, Tsurushita, Naoya

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Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates von Hinton, Paul R., Johlfs, Mary G., Xiong, Joanna M., Hanestad, Kelly, Ong, Kelly C., Bullock, Chuck, Keller, Stephen, Tang, Meina Tao, Tso, J. Yun, Vásquez, Max, Tsurushita, Naoya

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An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV von Guo, Hailong, Cho, Bomsoo, Hinton, Paul R, He, Sijia, Yu, Yongjun, Ramesh, Ashwin Kumar, Sivaccumar, Jwala Priyadarsini, Ku, Zhiqiang, Campo, Kristen, Holland, Sarah, Sachdeva, Sameer, Mensch, Christopher, Dawod, Mohamed, Whitaker, Annalis, Eisenhauer, Philip, Falcone, Allison, Honce, Rebekah, Botten, Jason W, Carroll, Stephen F, Keyt, Bruce A, Womack, Andrew W, Strohl, William R, Xu, Kai, Zhang, Ningyan, An, Zhiqiang, Ha, Sha, Shiver, John W, Fu, Tong-Ming

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Design, creation and in vitro testing of a reduced immunogenicity humanized anti-CD25 monoclonal antibody that retains functional activity von Stickler, Marcia, Reddy, Anita, Xiong, Joanna M, Wong, Melanie H, Akamatsu, Yoshiko, Hinton, Paul R, Harding, Fiona A

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Design of humanized antibodies: From anti-Tac to Zenapax von Tsurushita, Naoya, Hinton, Paul R., Kumar, Shankar

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1078 Agonistic CD40 IgM antibodies enhance immune responses beyond that of IgGs von Tartey, Sarang, Narayanaswamy, Vignesh, Pandya, Deepal, Krishnoji Rao, Vidhya Bai, Perez, Elizabeth, Hinton, Paul, Ng, Dean, Muchhal, Umesh, Keyt, Bruce, Sinclair, Angus, Phee, Hyewon

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1174 Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity von Li, Keyu, Xue, Jie, Pandya, Deepal, Yakkundi, Poonam, Li, Gene, Mai, Kristene, Hanna, Nardeen, Ye, Zhongde, Rosete, Rodnie, Wang, Jinqiu, Mao, Tina, Krishnoji Rao, Vidhya Bai, Perez, Elizabeth, Chudasama, Palak, Wang, Yue, Rahman, Sachi, Malik, Zee, Hinton, Paul, Bzymek, Krzysztof, Keyt, Bruce, Liu, Liqin, Sinclair, Angus, Muchhal, Umesh

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1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo von Kothambawala, Tasnim, Wai, Thin, Yakkundi, Poonam, Santos, Natalia L dos, Smith, Adam, Bolton, Gary, Bharti, Aditya, Banoth, Balaji, Pandya, Deepal, Krishnoji Rao, Vidhya Bai, Perez, Elizabeth, Rahman, Sachi, Hinton, Paul, Cao, Yuan, Horwitz, Harrison, Ng, Dean, Muchhal, Umesh, Keyt, Bruce A, Sinclair, Angus M, Phee, Hyewon, Wang, Beatrice

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The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to Zenapax von Ganguly, Bishu, Balasa, Balaji, Efros, Lyubov, Hinton, Paul R, Hartman, Stephen, Thakur, Archana, Xiong, Joanna M, Schmidt, Brian, Robinson, Randy R, Sornasse, Thierry, Vexler, Vladimir, Sheridan, James P

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P815: HIGH VALENCY OF IGM‐2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING von Hart, Kevin C., Santos, Daniel, Pandya, Deepal, Deng, Rong, LI, Keyu, Guan, Yinghui, Hernandez, Genevive, Manley, Thomas, Leabman, Maya K., Hinton, Paul R., Liu, Liqin, Sinclair, Angus M., Candia, Albert F., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

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Dissociation of Tc-99m DTPA in a nebulizer von Hinton, Paul J, Clauss, Ralf P

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Comparison of different methods of DatSCAN quantification von Morton, Rosemary J, Guy, Matthew J, Clauss, Ralf, Hinton, Paul J, Marshall, Craig A, Clarke, Elizabeth A

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Host–microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake von Pedersen, Camilla, Gallagher, Edith, Horton, Felicity, Ellis, Richard J., Ijaz, Umer Z., Wu, Huihai, Jaiyeola, Etana, Diribe, Onyinye, Duparc, Thibaut, Cani, Patrice D., Gibson, Glenn R., Hinton, Paul, Wright, John, La Ragione, Roberto, Robertson, M. Denise

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CD123 Directed IgM Antibody-based T-cell Engager, IGM-2537, Demonstrates Potent in vitro and in vivo Activity with Minimal Cytokine Release von Liu, Liqin, Li, Gene, Wang, Ling, Yakkundi, Poonam, Hinton, Paul R., Pandya, Deepal, Amoury, Manal, Sekar, Keerthana, Liu, Chian, Rosete, Rodnie, Hanna, Nardeen, Kotturi, Maya F., Bogaert, Liz, Hong, Jiyoung, Tsai, Christina, Keyt, Bruce A., Sinclair, Angus M.

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Igm-2644, a Novel CD38xCD3 Bispecific IgM T Cell Engager Demonstrates Potent Efficacy on Myeloma Cells with an Improved Preclinical Safety Profile von Li, Keyu, Yun, Rui, Chai, Min, Yakkundi, Poonam, Rosete, Rodnie, Li, Gene, Liu, Liqin, Ng, Dean, Hinton, Paul R., Kotturi, Maya F., Sinclair, Angus M., Carroll, Stephen F., Muchhal, Umesh, Keyt, Bruce A.

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Novel CD123xCD3 Bispecific Igm Antibody, Igm-2537, Potently Induces T-Cell Mediated Cytotoxicity of Acute Myeloid Leukemia Cells In Vivo and in Vitro with Minimal Cytokine Release von Li, Gene, Ye, Zhongde, Yakkundi, Poonam, Manlusoc, Marigold, Logronio, Kathryn, Tahrani, Leyla, Rosete, Rodnie, Bernados, David, Hinton, Paul, Pandya, Deepal, Hanna, Nardeen, Anantam, Jey, Kotturi, Maya F, Bogaert, Liz, Hong, Jiyoung, Tsai, Christina, Manley, Thomas, Keyt, Bruce A, Sinclair, Angus M., Liu, Liqin

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Abstract 1702: Multimeric anti-DR5 IgM antibody displays potent cytotoxicity in vitro and promotes tumor regression in vivo von Wang, Beatrice, Kothambalwala, Tasnim, Hinton, Paul, Ng, Dean, Saini, Avneesh, Baliga, Ramesh, Keyt, Bruce

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Abstract 5664: A bispecific IgM antibody format for enhanced T cell dependent killing with minimal cytokine release von Baliga, Ramesh, Li, Keyu, Manlusoc, Marigold, Hinton, Paul R., Ng, Dean C., Tran, Madeline H., Shan, Bing, Lu, Hai, Saini, Avneesh, Rahman, Sachi, Cao, Yuan C., Saraiya, Chitra, Peterson, Marvin S., Carroll, Stephen F., Chen, Daniel S., Keyt, Bruce A.

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Lymphoma cell-killing activity and cytokine release by CD20-directed bispecific IgM antibody-based T-cell engager (IGM-2323) von Keyt, Bruce, Baliga, Ramesh, Li, Keyu, Manlusoc, Marigold, Hinton, Paul, Ng, Dean, Tran, Madeline, Shan, Bing, Lu, Hai, Rahman, Sachi, Saini, Avneesh, Cao, Yuan, Saraiya, Chitra, Peterson, Marvin, Godfrey, Wayne R, Carroll, Steve

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