Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors von Dementiev, Alexey, Silva, Abel, Yee, Calvin, Li, Zhe, Flavin, Michael T., Sham, Hing, Partridge, James R.

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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics von Chen, Zehan, Xiao, Zhan, Gu, Wen‐zhen, Xue, John, Bui, Mai H., Kovar, Peter, Li, Gaoquan, Wang, Gary, Tao, Zhi‐Fu, Tong, Yunsong, Lin, Nan‐Horng, Sham, Hing L., Wang, Jean Y. J., Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying

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Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors von Liu, Gang, Lynch, John K, Freeman, Jennifer, Liu, Bo, Xin, Zhili, Zhao, Hongyu, Serby, Michael D, Kym, Philip R, Suhar, Tom S, Smith, Harriet T, Cao, Ning, Yang, Ruojing, Janis, Rich S, Krauser, Joel A, Cepa, Steven P, Beno, David W. A, Sham, Hing L, Collins, Christine A, Surowy, Teresa K, Camp, Heidi S

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors von Xu, Ying-zi, Yuan, Shendong, Bowers, Simeon, Hom, Roy K., Chan, Wayman, Sham, Hing L., Zhu, Yong L., Beroza, Paul, Pan, Hu, Brecht, Eric, Yao, Nanhua, Lougheed, Julie, Yan, Jiangli, Tam, Danny, Ren, Zhao, Ruslim, Lany, Bova, Michael P., Artis, Dean R.

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Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues:  Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation von Wang, Le, Woods, Keith W, Li, Qun, Barr, Kenneth J, McCroskey, Richard W, Hannick, Steven M, Gherke, Laura, Credo, R. Bruce, Hui, Yu-Hua, Marsh, Kennan, Warner, Robert, Lee, Jang Y, Zielinski-Mozng, Nicolette, Frost, David, Rosenberg, Saul H, Sham, Hing L

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Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer von Li, Qun, Sham, Hing L

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Novel cinnoline-based inhibitors of LRRK2 kinase activity von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Bowers, Simeon, Franzini, Maurizio, Goldbach, Erich, Lorentzen, Colin, Neitz, R. Jeffrey, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor von Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

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Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors von Xin, Zhili, Zhao, Hongyu, Serby, Michael D., Liu, Bo, Liu, Mei, Szczepankiewicz, Bruce G., Nelson, Lissa T.J., Smith, Harriet T., Suhar, Tom S., Janis, Rich S., Cao, Ning, Camp, Heidi S., Collins, Christine A., Sham, Hing L., Surowy, Teresa K., Liu, Gang

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Triazolopyridazine LRRK2 kinase inhibitors von Franzini, Maurizio, Ye, Xiaocong M., Adler, Marc, Aubele, Danielle L., Garofalo, Albert W., Gauby, Shawn, Goldbach, Erich, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh, Ren, Zhao

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors von Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model von Truong, Anh P., Tóth, Gergley, Probst, Gary D., Sealy, Jennifer M., Bowers, Simeon, Wone, David W.G., Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Wu, Jing, Peterson, Brian T., Ruslim, Lany, Bova, Michael P., Kholodenko, Dora, Motter, Ruth N., Bard, Frédérique, Santiago, Pamela, Ni, Huifang, Chian, David, Soriano, Ferdie, Cole, Tracy, Brigham, Elizabeth F., Wong, Karina, Zmolek, Wes, Goldbach, Erich, Samant, Bhushan, Chen, Linda, Zhang, Hongbing, Nakamura, David F., Quinn, Kevin P., Yednock, Ted A., Sauer, John-Michael

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Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity von Szczepankiewicz, Bruce G, Kosogof, Christi, Nelson, Lissa T. J, Liu, Gang, Liu, Bo, Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Liu, Mei, Gum, Rebecca J, Haasch, Deanna L, Wang, Sanyi, Clampit, Jill E, Johnson, Eric F, Lubben, Thomas H, Stashko, Michael A, Olejniczak, Edward T, Sun, Chaohong, Dorwin, Sarah A, Haskins, Kristi, Abad-Zapatero, Cele, Fry, Elizabeth H, Hutchins, Charles W, Sham, Hing L, Rondinone, Cristina M, Trevillyan, James M

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors von Ng, Raymond A., Sun, Minghua, Bowers, Simeon, Hom, Roy K., Probst, Gary D., John, Varghese, Fang, Lawrence Y., Maillard, Michel, Gailunas, Andrea, Brogley, Louis, Neitz, R. Jeffrey, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Adler, Marc, Yao, Nanhua, Zmolek, Wes, Nakamura, David, Quinn, Kevin P., Sauer, John-Michael, Bova, Michael P., Ruslim, Lany, Artis, Dean R., Yednock, Ted A.

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor von Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce [alpha]-Synuclein Phosphorylation in Rat Brain von Aubele, Danielle L, Hom, Roy K, Adler, Marc, Galemmo, Robert A, Bowers, Simeon, Truong, Anh P, Pan, Hu, Beroza, Paul, Neitz, R Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P, Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W, Latimer, Lee, Zhu, Yong L, Sham, Hing L, Anderson, John P, Bergeron, Marcelle, Artis, Dean R

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluorome... von Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors von Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Szczepankiewicz, Bruce G, Liu, Mei, Kosogof, Christi, Liu, Bo, Nelson, Lissa T. J, Johnson, Eric F, Wang, Sanyi, Pederson, Terry, Gum, Rebecca J, Clampit, Jill E, Haasch, Deanna L, Abad-Zapatero, Cele, Fry, Elizabeth H, Rondinone, Cristina, Trevillyan, James M, Sham, Hing L, Liu, Gang

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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors von Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Longenecker, Kenton, Pireh, Daisy, Stewart, Kent D, Backes, Bradley J, Lai, Chunqiu, Lubben, Thomas H, Ballaron, Stephen J, Beno, David W. A, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M

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