BACE1 inhibitors: A head group scan on a series of amides von Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert

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Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE―/― mice von BOT, Ilze, BOT, Martine, BIESSEN, Erik A. L, VAN HEININGEN, Sandra H, VAN SANTBRINK, Peter J, LANKHUIZEN, Inge M, HARTMAN, Peter, GRUENER, Sabine, HILPERT, Hans, VAN BERKEL, Theo J. C, FINGERLE, Jürgen

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Efficient Synthesis of Novel NK1 Receptor Antagonists:  Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives von Hoffmann-Emery, Fabienne, Hilpert, Hans, Scalone, Michelangelo, Waldmeier, Pius

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Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice von Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd

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β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease von Hilpert, Hans, Guba, Wolfgang, Woltering, Thomas J, Wostl, Wolfgang, Pinard, Emmanuel, Mauser, Harald, Mayweg, Alexander V, Rogers-Evans, Mark, Humm, Roland, Krummenacher, Daniela, Muser, Thorsten, Schnider, Christian, Jacobsen, Helmut, Ozmen, Laurence, Bergadano, Alessandra, Banner, David W, Hochstrasser, Remo, Kuglstatter, Andreas, David-Pierson, Pascale, Fischer, Holger, Polara, Alessandra, Narquizian, Robert

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Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function von Oliverio, Matteo, Schmidt, Elena, Mauer, Jan, Baitzel, Catherina, Hansmeier, Nils, Khani, Sajjad, Konieczka, Sandra, Pradas-Juni, Marta, Brodesser, Susanne, Van, Trieu-My, Bartsch, Deniz, Brönneke, Hella S., Heine, Markus, Hilpert, Hans, Tarcitano, Emilio, Garinis, George A., Frommolt, Peter, Heeren, Joerg, Mori, Marcelo A., Brüning, Jens C., Kornfeld, Jan-Wilhelm

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Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass von Esterházy, Daria, Stützer, Ina, Wang, Haiyan, Rechsteiner, Markus P., Beauchamp, Jeremy, Döbeli, Heinz, Hilpert, Hans, Matile, Hugues, Prummer, Michael, Schmidt, Alexander, Lieske, Nora, Boehm, Bernhard, Marselli, Lorella, Bosco, Domenico, Kerr-Conte, Julie, Aebersold, Ruedi, Spinas, Giatgen Andreia, Moch, Holger, Migliorini, Cristiano, Stoffel, Markus

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Multiselective enzymatic reactions for the synthesis of protected homochiral cis- and trans-1,3,5-cyclohexanetriols von Wirz, Beat, Iding, Hans, Hilpert, Hans

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Novel versatile approach to an enantiopure 19-nor, des-C,D vitamin D3 derivative von Hilpert, Hans, Wirz, Beat

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Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds von Hilpert, Hans, Mauser, Harald, Humm, Roland, Anselm, Lilli, Kuehne, Holger, Hartmann, Guido, Gruener, Sabine, Banner, David W, Benz, Joerg, Gsell, Bernard, Kuglstatter, Andreas, Stihle, Martine, Thoma, Ralf, Sanchez, Rubén Alvarez, Iding, Hans, Wirz, Beat, Haap, Wolfgang

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Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes von Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Boehringer, Markus, Grether, Uwe, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel, Mohr, Peter

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Combined Treatment with a BACE Inhibitor and Anti-A beta Antibody Gantenerumab Enhances Amyloid Reduction in APP sub(London) Mice von Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd

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Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP London Mice von Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd

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Practical approaches to the matrix metalloproteinase inhibitor Trocade ® (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315 von Hilpert, Hans

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Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones von Banner, David W., Gsell, Bernard, Benz, Jörg, Bertschinger, Julian, Burger, Dominique, Brack, Simon, Cuppuleri, Simon, Debulpaep, Maja, Gast, Alain, Grabulovski, Dragan, Hennig, Michael, Hilpert, Hans, Huber, Walter, Kuglstatter, Andreas, Kusznir, Eric, Laeremans, Toon, Matile, Hugues, Miscenic, Christian, Rufer, Arne C., Schlatter, Daniel, Steyaert, Jan, Stihle, Martine, Thoma, Ralf, Weber, Martin, Ruf, Armin

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Structure-based design of indole propionic acids as novel PPARα/γ co-agonists von Kuhn, Bernd, Hilpert, Hans, Benz, Jörg, Binggeli, Alfred, Grether, Uwe, Humm, Roland, Märki, Hans Peter, Meyer, Markus, Mohr, Peter

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Novel versatile approach to an enantiopure 19- nor, des-C,D vitamin D 3 derivative von Hilpert, Hans, Wirz, Beat

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Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-pheny... von Anselm, Lilli, Banner, David W., Benz, Jörg, Groebke Zbinden, Katrin, Himber, Jacques, Hilpert, Hans, Huber, Walter, Kuhn, Bernd, Mary, Jean-Luc, Otteneder, Michael B., Panday, Narendra, Ricklin, Fabienne, Stahl, Martin, Thomi, Stefan, Haap, Wolfgang

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Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research von Göhring, Wolfgang, Gokbale, Surendra, Hilpert, Hans, Roessler, Felix, Schlageter, Markus, Vogt, Peter

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Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists von Grether, Uwe, Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Mohr, Peter, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel

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