A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models von Stennicke, Henning R., Kjalke, Marianne, Karpf, Ditte M., Balling, Kristoffer W., Johansen, Peter B., Elm, Torben, Øvlisen, Kristine, Möller, Flemming, Holmberg, Heidi L., Gudme, Charlotte N., Persson, Egon, Hilden, Ida, Pelzer, Hermann, Rahbek-Nielsen, Henrik, Jespersgaard, Christina, Bogsnes, Are, Pedersen, Anette A., Kristensen, Anne K., Peschke, Bernd, Kappers, Wendy, Rode, Frederik, Thim, Lars, Tranholm, Mikael, Ezban, Mirella, Olsen, Eva H.N., Bjørn, Søren E.

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Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model von Hilden, Ida, Lauritzen, Brian, Sørensen, Brit Binow, Clausen, Jes Thorn, Jespersgaard, Christina, Krogh, Berit Olsen, Bowler, Andrew Neil, Breinholt, Jens, Gruhler, Albrecht, Svensson, L. Anders, Petersen, Helle Heibroch, Petersen, Lars Christian, Balling, Kristoffer W., Hansen, Lene, Hermit, Mette Brunsgaard, Egebjerg, Thomas, Friederichsen, Birgitte, Ezban, Mirella, Bjørn, Søren Erik

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TFPIα interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation von Wood, Jeremy P., Petersen, Helle H., Yu, Bingke, Wu, Xiaoai, Hilden, Ida, Mast, Alan E.

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Concizumab promotes haemostasis via a tissue factor‐factor VIIa–dependent mechanism supporting prophylactic treatment of haemophilia: Results from a rabbit haemophilia bleeding mod... von Lauritzen, Brian, Hilden, Ida

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Concizumab Promotes Hemostasis Via a TF-FVIIa Dependent Mechanism As Shown in a Rabbit Hemophilia Bleeding Model von Lauritzen, Brian, Hilden, Ida

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Thrombin Generation Assay in Plasma from Hemophilia a Patients with or without Inhibitors on Concizumab Prophylaxis: Spiking with rFVIIa or aPCC von Kjalke, Marianne, Kjelgaard-Hansen, Mads, Andersen, Søren, Hilden, Ida

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Thrombin generation potential in the presence of concizumab and rFVIIa, APCC, rFVIII, or rFIX: In vitro and ex vivo analyses von Kjalke, Marianne, Kjelgaard‐Hansen, Mads, Andersen, Søren, Hilden, Ida

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Evaluation of a Next-Generation FVIII Mimetic Antibody, Mim8, in Combination with Recombinant FVIIa, FVIII and Activated Prothrombin Complex Concentrate von Burnier, Laurent, Hermit, Mette B, Hilden, Ida, Ezban, Mirella, Kjellev, Stine L

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A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice von Østergaard, Henrik, Lund, Jacob, Greisen, Per J., Kjellev, Stine, Henriksen, Anette, Lorenzen, Nikolai, Johansson, Eva, Røder, Gustav, Rasch, Morten G., Johnsen, Laust B., Egebjerg, Thomas, Lund, Søren, Rahbek-Nielsen, Henrik, Gandhi, Prafull S., Lamberth, Kasper, Loftager, Mette, Andersen, Lisbeth M., Bonde, Amalie C., Stavenuiter, Fabian, Madsen, Daniel E., Li, Xun, Holm, Thomas L., Ley, Carsten D., Thygesen, Peter, Zhu, Haisun, Zhou, Rong, Thorn, Karina, Yang, Zhiru, Hermit, Mette B., Bjelke, Jais R., Hansen, Bjarne G., Hilden, Ida

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Administration of recombinant FVIIa (rFVIIa) to concizumab‐dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits von Lauritzen, Brian, Olling, Janne, Abel, Kristin L., Augustsson, Cecilia, Balling, Kristoffer, Bjelke, Mads, Hegelund, Anne Charlotte, Hilden, Ida

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Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo von Ley, Carsten Dan, Holm, Thomas Lindebo, Elenius, Daniel, Holmberg, Heidi Lindgreen, Bjelke, Jais Rose, Loftager, Mette, Hermit, Mette B, Hilden, Ida, Kjellev, Stine L

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Inhibitory effects of LDL-associated tissue factor pathway inhibitor von Augustsson, Cecilia, Hilden, Ida, Petersen, Lars C

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Measurement of plasma and platelet tissue factor pathway inhibitor, factor V and Protein S in people with haemophilia von Ellery, Paul E. R., Hilden, Ida, Thyregod, Peter, Martinez, Nicholas D., Maroney, Susan A., Gill, Joan C., Mast, Alan E.

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Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus monkeys after iv and sc administration von Agersø, Henrik, Overgaard, Rune Viig, Petersen, Mads Bjelke, Hansen, Lene, Hermit, Mette Brunsgaard, Sørensen, Mette Høgh, Petersen, Lars Christian, Hilden, Ida

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Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets von Enoksson, Mari, Martin, Erika J., Holmberg, Heidi, Jensen, Mette S., Kjelgaard‐Hansen, Mads, Egebjerg, Thomas, Buchardt, Jens, Krogh, Thomas N., Demuth, Helle, Sanfridson, Annika, Hilden, Ida, Kjalke, Marianne, Brophy, Donald F.

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Kunitz 3-Selective but Not Kunitz 2-Selective TFPI Inhibitors Cause Release of Tfpiα from Endothelial Cells: Insights into the Release Mechanism von Peterson, Julie A., Augustsson, Cecilia, Maroney, Susan A, Heibroch Petersen, Helle, Hilden, Ida, Mast, Alan, Zwifelhofer, Wes

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Mim8 - a Next-Generation FVIII Mimetic Bi-Specific Antibody - Potently Restores the Hemostatic Capacity in Hemophilia a Settings in Vitro and In Vivo von Kjellev, Stine L, Østergaard, Henrik, Greisen, Per Jr, Hermit, Mette B, Thorn, Karina, Hansen, Bjarne G, Zhou, Rong, Bjelke, Jais Rose, Kjalke, Marianne, Lund, Jacob, Holm, Thomas L, Ley, Carsten Dan, Elenius, Daniel, Thygesen, Peter, Loftager, Mette, Rasch, Morten G, Lorenzen, Nikolai, Gandhi, Prafull S, Lamberth, Kasper, Egebjerg, Thomas, Lund, Søren, Henriksen, Anette, Rahbek-Nielsen, Henrik, Yang, Zhiru, Hilden, Ida

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Characterization and crystallization of an active N‐terminally truncated form of the Escherichia coli glycogen branching enzyme von Hilden, Ida, Leggio, Leila L., Larsen, Sine, Poulsen, Peter

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Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1) von Øie, Cristina Ionica, Appa, Rupa Shree, Hilden, Ida, Petersen, Helle Heibroch, Gruhler, Albrecht, Smedsrød, Bård, Hansen, John-Bjarne

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Plasma and Platelet Tissue Factor Pathway Inhibitor (TFPI) in Blood Donors and in People with Hemophilia von Ellery, Paul E.R., Augustsson, Cecilia, Andersen, Soren, Maroney, Susan A., Wood, Jeremy P, Gill, Joan Cox, Hilden, Ida, Mast, Alan E.

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