DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery von Ye, Chaoyang, Ho, Daniel J., Neri, Marilisa, Yang, Chian, Kulkarni, Tripti, Randhawa, Ranjit, Henault, Martin, Mostacci, Nadezda, Farmer, Pierre, Renner, Steffen, Ihry, Robert, Mansur, Leandra, Keller, Caroline Gubser, McAllister, Gregory, Hild, Marc, Jenkins, Jeremy, Kaykas, Ajamete

Volltext

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion von Keller, Caroline Gubser, Shin, Youngah, Monteys, Alex Mas, Renaud, Nicole, Beibel, Martin, Teider, Natalia, Peters, Thomas, Faller, Thomas, St-Cyr, Sophie, Knehr, Judith, Roma, Guglielmo, Reyes, Alejandro, Hild, Marc, Lukashev, Dmitriy, Theil, Diethilde, Dales, Natalie, Cha, Jang-Ho, Borowsky, Beth, Dolmetsch, Ricardo, Davidson, Beverly L., Sivasankaran, Rajeev

Volltext

Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE von Cho, Hyelim, Geno, Erin, Patoor, Maude, Reid, Adam, McDonald, Rick, Hild, Marc, Jenkins, Jeremy L

Volltext

Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins von Beisel, Christian, Buness, Andreas, Roustan-Espinosa, Ian M, Koch, Britta, Schmitt, Sabine, Haas, Stefan A, Hild, Marc, Katsuyama, Tomonori, Paro, Renato

Volltext

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo von Hild, M, Dick, A, Rauch, G J, Meier, A, Bouwmeester, T, Haffter, P, Hammerschmidt, M

Volltext

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling von Bauer, Andreas, Myer, Vic, Fawell, Stephen, Ghidelli, Sonja, Shi, Xiaoying, Rau, Christina, Schirle, Markus, Serluca, Fabrizio, Zhang, Yue, Bouwmeester, Tewis, Charlat, Olga, Mickanin, Craig, Curtis, Daniel, Stegmeier, Frank, Hild, Marc, Cong, Feng, Mishina, Yuji M, Wilson, Christopher J, Liu, Shanming, Wiessner, Stephanie, Tomlinson, Ronald, Fazal, Aleem, Shao, Wenlin, Shultz, Michael, Wiellette, Elizabeth, Michaud, Gregory A, Cheng, Hong, Schlegl, Judith, Finan, Peter M, Porter, Jeffery A, Lu, Chris, Cheung, Atwood, Lengauer, Christoph, Tallarico, John A, Kirschner, Marc W, Huang, Shih-Min A

Volltext

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS von Taylor, J. Paul, Pandey, Udai Bhan, Nie, Zhiping, Batlevi, Yakup, McCray, Brett A, Ritson, Gillian P, Nedelsky, Natalia B, Schwartz, Stephanie L, DiProspero, Nicholas A, Knight, Melanie A, Schuldiner, Oren, Padmanabhan, Ranjani, Hild, Marc, Berry, Deborah L, Garza, Dan, Hubbert, Charlotte C, Yao, Tso-Pang, Baehrecke, Eric H

Volltext

Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells von Boutros, Michael, Kiger, Amy A., Armknecht, Susan, Kerr, Kim, Hild, Marc, Koch, Britta, Haas, Stefan A., Heidelberg Fly Array Consortium, Paro, Renato, Perrimon, Norbert

Volltext

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism von Cho, Hyelim, Shen, Qiong, Zhang, Lydia H., Okumura, Mikiko, Kawakami, Akinori, Ambrose, Jessi, Sigoillot, Frederic, Miller, Howard R., Gleim, Scott, Cobos-Correa, Amanda, Wang, Ying, Piechon, Philippe, Roma, Guglielmo, Eggimann, Fabian, Moore, Charles, Aspesi, Peter, Mapa, Felipa A., Burks, Heather, Ross, Nathan T., Krastel, Philipp, Hild, Marc, Maimone, Thomas J., Fisher, David E., Nomura, Daniel K., Tallarico, John A., Canham, Stephen M., Jenkins, Jeremy L., Forrester, William C.

Volltext

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery von Li, Jingyao, Ho, Daniel J., Henault, Martin, Yang, Chian, Neri, Marilisa, Ge, Robin, Renner, Steffen, Mansur, Leandra, Lindeman, Alicia, Kelly, Brian, Tumkaya, Tayfun, Ke, Xiaoling, Soler-Llavina, Gilberto, Shanker, Gopi, Russ, Carsten, Hild, Marc, Gubser Keller, Caroline, Jenkins, Jeremy L., Worringer, Kathleen A., Sigoillot, Frederic D., Ihry, Robert J.

Volltext

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity von Carbonneau, Seth, Sharma, Sujata, Peng, Liaomin, Rajan, Vaisakh, Hainzl, Dominik, Henault, Martin, Yang, Chian, Hale, Jacob, Shulok, Janine, Tallarico, John, Porter, Jeff, Brogdon, Jennifer L., Dranoff, Glenn, Bradner, James E., Hild, Marc, Guimaraes, Carla P.

Volltext

Zebrafish ΔNp63 Is a Direct Target of Bmp Signaling and Encodes a Transcriptional Repressor Blocking Neural Specification in the Ventral Ectoderm von Bakkers, Jeroen, Hild, Marc, Kramer, Carina, Furutani-Seiki, Makoto, Hammerschmidt, Matthias

Volltext

Production of 3‐D Airway Organoids From Primary Human Airway Basal Cells and Their Use in High‐Throughput Screening von Hild, Marc, Jaffe, Aron B.

Volltext

Glucagon Treatment Interferes with an Early Step of Duck Hepatitis B Virus Infection von Hild, M, Weber, O, Schaller, H

Volltext

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity von Carbonneau, Seth, Sharma, Sujata, Peng, Liaomin, Rajan, Vaisakh, Hainzl, Dominik, Henault, Martin, Yang, Chian, Hale, Jacob, Shulok, Janine, Tallarico, John, Porter, Jeff, Brogdon, Jennifer L., Dranoff, Glenn, Bradner, James E., Hild, Marc, Guimaraes, Carla P.

Volltext

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration von Al-Ramahi, Ismael, Lu, Boxun, Di Paola, Simone, Pang, Kaifang, de Haro, Maria, Peluso, Ivana, Gallego-Flores, Tatiana, Malik, Nazish T., Erikson, Kelly, Bleiberg, Benjamin A., Avalos, Matthew, Fan, George, Rivers, Laura Elizabeth, Laitman, Andrew M., Diaz-García, Javier R., Hild, Marc, Palacino, James, Liu, Zhandong, Medina, Diego L., Botas, Juan

Volltext

A Novel Luminescence-Based High-Throughput Approach for Cellular Resolution of Protein Ubiquitination Using Tandem Ubiquitin Binding Entities (TUBEs) von Akinjiyan, Favour A., Fazal, Aleem, Hild, Marc, Beckwith, Rohan E. J., Ross, Nathan T., Paulk, Joshiawa, Carbonneau, Seth

Volltext

Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster von Chen, Jian, Shi, Xiaoying, Padmanabhan, Ranjani, Wang, Qiong, Wu, Zhidan, Stevenson, Susan C, Hild, Marc, Garza, Dan, Li, Hao

Volltext

In vivo analysis of compound activity and mechanism of action using epistasis in Drosophila von Bangi, Erdem, Garza, Dan, Hild, Marc

Volltext

Abstract 3737: Identifying novel therapeutic targets for cancer stem cell differentiation von Reyes, Germán L. Vélez, Yang, Haidi, Wilson, Aaron, Henault, Martin, Frias, Elizabeth, Schlabach, Michael, Mclaughlin, Margaret, Ross, Nathan, Hoffman, Gregory, Chen, Amy, Hild, Marc, Jaffe, Aron

Volltext